Table Of ContentAdvances in Experimental Medicine and Biology 1195
Panayiotis Vlamos Editor
GeNeDis
2018
Genetics and Neurodegeneration
Advances in Experimental Medicine
and Biology
Volume 1195
Series Editors
Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de
Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France
John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA
Heinfried H. Radeke, Clinic of the Goethe University Frankfurt Main, Institute of
Pharmacology & Toxicology, Frankfurt am Main, Germany
Nima Rezaei, Research Center for Immunodeficiencies, Children’s Medical Center,
Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Panayiotis Vlamos
Editor
GeNeDis 2018
Genetics and Neurodegeneration
Editor
Panayiotis Vlamos
Department of Informatics
Ionian University
Corfu, Greece
ISSN 0065-2598 ISSN 2214-8019 (electronic)
Advances in Experimental Medicine and Biology
ISBN 978-3-030-32632-6 ISBN 978-3-030-32633-3 (eBook)
https://doi.org/10.1007/978-3-030-32633-3
© Springer Nature Switzerland AG 2020
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To my father… who is gone.
Acknowledgment
I would like to thank Konstantina Skolariki for the help she provided during the
editorial process.
vii
Contents
In Silico and In Vivo Studies on Quercetin as Potential
Anti-Parkinson Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Hemanth Kumar Boyina, Sree Lakshmi Geethakhrishnan,
Swetha Panuganti, Kiran Gangarapu, Krishna Prasad Devarakonda,
Vasudha Bakshi, and Sandhya Rani Guggilla
Exhaled Breath Condensate (EBC): Is It a Viable Source
of Biomarkers for Lung Diseases? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Stefanos Patsiris, Themis Exarchos, and Panayiotis Vlamos
Treatment Development for Alzheimer’s Disease:
How Are We Doing? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Constantin George Lyketsos
Microbiome Hijacking Towards an Integrative Pest
Management Pipeline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
Vasiliki Lila Koumandou, Louis Papageorgiou,
Spyridon Champeris Tsaniras, Aegli Papathanassopoulou,
Marianna Hagidimitriou, Nikos Cosmidis, and Dimitrios Vlachakis
Regulation and Roles of Autophagy in the Brain . . . . . . . . . . . . . . . . . . . . . 33
Nektarios Tavernarakis
Three-Dimensional Models for Studying Neurodegenerative
and Neurodevelopmental Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
Stavroula Tsaridou, Margarita Skamnelou, Marianna Iliadou,
Georgia Lokka, Evangelia Parlapani, Maria Mougkogianni,
Rodolfos- Iosif Danalatos, Anastasia Kanellou,
Dimitris-David Chlorogiannis, Christina Kyrousi,
and Stavros Taraviras
ix
x Contents
Assessment of Factors Contributing to the Enhancement of Memory
and Cognitive Abilities in the Context of Neurosciences . . . . . . . . . . . . . . . 43
Spyridon Ktenas
Buccal Mucosa Biomarkers in Alzheimer’s Disease . . . . . . . . . . . . . . . . . . 49
Antigoni Avramouli and Panayiotis Vlamos
Engaging Social Interest and Creating Awareness for the Behavioural
and Psychological Symptoms of Dementia . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Kristine Newman
Structural Study of the DNA: Clock/Bmal1 Complex Provides
Insights for the Role of Cortisol, hGR, and HPA Axis in Stress
Management and Sleep Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Sofia Raftopoulou, Nicolas C. Nicolaides, Louis Papageorgiou, Anastasia
Amfilochiou, Spyros G. Zakinthinos, Potamitis George, Elias Eliopoulos,
George P. Chrousos, and Dimitrios Vlachakis
The Effects of Quantum Entanglement on Chromatin
and Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Michael Harney
Olive Oil Polyphenols in Neurodegenerative Pathologies . . . . . . . . . . . . . . 77
Constantinos Salis, Louis Papageorgiou, Eleni Papakonstantinou,
Marianna Hagidimitriou, and Dimitrios Vlachakis
Human Pluripotent Stem Cells as In Vitro Models
of Neurodegenerative Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
Vasiliki Machairaki
Nutritional Lipidomics in Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . 95
Efstathia Kalli
Alzheimer’s Disease Therapeutic Approaches . . . . . . . . . . . . . . . . . . . . . . . 105
Maria Revi
Stress and Wellbeing of Psychiatry Trainees: A Literature Review . . . . . . 117
Rhoda Lai and Christos Plakiotis
Brief Cognitive Tests in the Case of Dementia and Alzheimer’s
Disease Early Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127
Maria Sagiadinou and Antonia Plerou
Synthesis, Molecular Docking Studies and Biological Evaluation
of N-Acylarylhydrazones as Anti- Inflammatory Agents . . . . . . . . . . . . . . . 137
Tangirala Sarala Devi, Galla Rajitha, Konda Swathi,
Katari Sudheer Kumar, and Amineni Umamaheswari
Contents xi
Exosome Biomarkers Revolutionize Preclinical Diagnosis
of Neurodegenerative Diseases and Assessment of Treatment
Responses in Clinical Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Dimitrios Kapogiannis
Biomarkers as a Different Approach in Prevention and Treatment
of Drug Addiction (Preliminary Study) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Maria Gonidi, Anna Tselenti, and Antonia Plerou
Sleep Disorders and Restless Legs Syndrome in Hemodialysis
Patients in Greece: A Cross-Sectional Study . . . . . . . . . . . . . . . . . . . . . . . . 155
Pantelis Stergiannis, Maria Govari, Edison Jahaj, Christina Marvaki,
Georgia Toulia, Katerina Marvaki, Georgia Chasioti, and George Intas
Craniofacial and Neurological Phenotype in a Patient
with De Novo 18q Microdeletion and 18p Microduplication . . . . . . . . . . . 163
Christos Yapijakis, Antonia Angelopoulou, Emmanuel Manolakos,
and Costas Voumvourakis
What Do Recent Clinical Trials Teach Us About the Etiology of AD . . . . . 167
Nikolaos K. Robakis
Developmental Biology and Transgenic Avian Embryology:
Body Alterity Bioart Wet Lab . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Adam Zaretsky
Gene Editing, Sexual Reproduction, and the Arts: The Present,
the Future, and the Imagined. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177
Roberta Buiani
Amyotrophic Lateral Sclerosis: Current Status in Diagnostic
Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Katerina Kadena and Panayiotis Vlamos
Synthesis and Characterization of Biologically Significant
5-[N,N- dialkylamino alkoxy] azaindole 2-one, 3-thiosemicarbazones
and 5-[N,N-d ialkylamino alkoxy] azaindole 3-hydrazone, 2-ones . . . . . . . 189
Konda Swathi, Galla Rajitha, and Manda Sarangapani
Genetic Counseling for Adult-Onset Spinal and Bulbar
Muscular Atrophy (Kennedy Syndrome): Multiple Cases
of Prenatal Testing in a Family . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 199
Christos Yapijakis, Achilleas Laskaratos, Antonia Angelopoulou,
and Costas Voumvourakis
Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis . . . 205
Marios G. Krokidis
xii Contents
Ocimum Sanctum Linn: A Potential Adjunct Therapy
for Hyperhomocysteinemia-Induced Vascular Dementia . . . . . . . . . . . . . . 213
Jagadeesh Prasad Pasangulapati, Arun Reddy Ravula,
Dinesh Reddy Kanala, Dinesh Kumar Bharatraj, Shanmukhi Boyina,
Kiran Gangarapu, and Hemanth Kumar Boyina
Alzheimer’s Disease: The Role of Mutations in Protein Folding . . . . . . . . 227
Eleftheria Polychronidou, Antigoni Avramouli, and Panayiotis Vlamos
Regulatory Role of MicroRNAs in Brain Development and Function . . . . 237
Christos Yapijakis
The Misfolding of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249
Agathi Argyrou
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
