Food Allergy: Methods of Detection and Clinical Studies

321 Pages·2017·9.86 MB·English

by  Anas M. Abdel Rahman

FOOD ALLERGY
Methods of Detection and
Clinical Studies

FOOD ALLERGY
Methods of Detection and
Clinical Studies
Editor
Anas M. Abdel Rahman
Department of Genetics, Research Center
King Faisal Specialist Hospital and Research Center (KFSHRC)
and College of Medicine
Al-Faisal University
Riyadh
Saudi Arabia
p,
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A SCIENCE PUBLISHERS BOOK
A SCIENCE PUBLISHERS BOOK
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Preface
Bridging the gap between the clinicians and basic science researchers in
food allergy was the idea of writing this book. A few dozen of authors from
around the world were invited to share their bedside and bench top research
experience in the field of food allergy. We tried to cover all the clinical updates
in the first seven chapters starting from nomenclature to immunotherapy. The
other half of the book includes state of the art technology role in enhancing
the molecular knowledge in food allergy research and the updated experience
of the authors’ laboratories. The authors of these chapters introduced their
expertise in the novel technologies such as mass spectrometry and biosensors,
bioinformatics and databases, and the food labeling regulations. This book
will be a useful reading material for the young and expert scientists in food
allergy with the theme of introductory to the basic knowledge and literature
updates, respectively.

Contents
Preface v
1. Food Allergy Nomenclature 1
Sten Dreborg
2. Food Allergy in Children 14
Sophia Tsabouri, Gavriela Feketea and Nicolaos Nicolaou
3. Peanut Allergy: Clinical Relevance and Allergen Characterisation 35
Joana Costa, Caterina Villa, Telmo J.R. Fernandes, M. Beatriz P.P.
Oliveira and Isabel Mafra
4. The Pollen-Food Syndrome: An Update on Diagnostic and 58
Therapeutic Approaches
Sara Huber, Claudia Asam, Anargyros Roulias, Fatima Ferreira and
Lorenz Aglas
5. Advances in Seafood Allergy Research: Allergen Detection 80
and Allergen-Specific Immunotherapy
Nicki Y.H. Leung, Christine Y.Y. Wai, Ka Hou Chu and
Patrick S.C. Leung
6. Skin Prick/Puncture Testing in Food Allergy 106
Sten Dreborg
7. Immunotherapy for Food Allergy 131
Bright I. Nwaru and Aziz Sheikh
8. Allergenomics—A Strategy for Food Allergen Discovery 142
Anas M. Abdel Rahman
9. Proteomics in Food Allergy 160
Pasquale Ferranti, Anas M. Abdel Rhaman, Maria Adalgisa Nicolai
and Monica Gallo
10. Allergen Quantitation for Food Labeling 188
Martina Koeberl, Dean Clarke and Andreas L. Lopata
viii Food Allergy: Methods of Detection and Clinical Studies
11. Shellfish Allergy: Taking the Allergenomics Approach towards 205
Improved Allergen Detection and Diagnostics
Sandip D. Kamath and Andreas L. Lopata
12. Bioinformatics Approaches to Identifying the Cross-Reactive 225
Allergenic Risk of Novel Food Proteins
Ping Song, Rod A. Herman and Siva Kumpatla
13. The Pollen-Food Syndrome: A Molecular Perspective 246
Claudia Asam, Lorenz Aglas, Sara Huber, Fátima Ferreira and
Anargyros Roulias
14. Biotechnology: Methods for Assessing Potential Allergenicity 268
of Novel Proteins According to Global Regulations
Christal C. Bowman and Scott McClain
15. Advances in Biosensor Technologies for Food Allergen 289
Monitoring and Diagnosis
Shimaa Eissa, Raja Chinnappan and Mohammed Zourob
Index 311
CHAPTER 1
Food Allergy Nomenclature
Sten Dreborg
Introduction
Nomenclature is the basis for appropriate communication between scientists
and clinicians. Studies should be performed using defined methods, grouping
populations of patients with given characteristics, using words which describe
patients clearly enough to be understood by others. Results can be applied
to similar patients using the same methodology and patient characteristics
using established nomenclature. This makes nomenclature crucial to both
investigators as well as to clinicians to convey the message from research to
the clinic. Allergists as well as other scientists interested in allergy, and not
least lay persons and lay organizations must have a common language when
communicating.
The nomenclature of allergy and allergic diseases has varied from time
to time. However, within some areas confusing terms have been used such as
“non-atopic atopic dermatitis”, i.e., a dermatitis, clinically resembling that of
so called “atopic dermatitis” (with allergen specific IgE antibodies also called
eczema (Johansson et al., 2004)), but without allergen specific IgE antibodies.
That was, and still is, confusing. Accordingly, Gunnar O. Johansson formed a
task force within the European Academy of Allergy and Clinical Immunology,
EAACI, to write a position paper expressing the meaning of the Academy of
allergy nomenclature (Johansson et al., 2001). To make the message general he
later formed a group within the World Allergy Organization, WAO to discuss
the EAACI position paper (Johansson et al., 2001), adding views from other
continents and to agree on a common nomenclature for the worldwide allergy
community (Johansson et al., 2004). One of the main achievements was to start
using “eczema” instead of “atopic dermatitis”. However, as often happens,
Professor emeritus, Child and Adolescent Allergology, Women’s and Children’s Health Uppsala
University, Academic Hospital, SE-751 85 UPPSALA, Sweden.
Email: [email protected]