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Antibiotic Resistance: Super drugs for super bugs September 26th, 2013 Amy Rohlfing, Harvard University BBS Program Marina Santiago, Harvard University Chemical Biology Program John Santa Maria, Harvard University Chemical Biology Program Roadmap for the evening 1.  Background on bacteria and antibiotics 2.  How bacteria become antibiotic resistant 3.  The hunt for new antibiotics Outline Part I •  What are bacteria? •  How bacteria cause disease •  How antibiotics kill bacteria Need for new antibiotics Antibiotic deployment Antibiotic resistance observed Clatworthy, et al. Nature 2007. 3, 541-458 Need for new antibiotics Immune •  17 common disease MRSA cells causing bacteria have antibiotic resistant versions •  23,000 deaths/year from antibiotic resistant bacteria •  Some bacteria are resistant to nearly all antibiotics Antibiotic Resistance Threats in the United States, 2013, CDC Relative size of bacteria Adult Female Bacteria Virus Animal Atom Cel l Tennis Bal l Period . 0.1 100 1 100 1 10 1 nanometers nanometers micrometer micrometers millimeter centimeters meter Thomas Splettstoesser, Wikimedia commons Nossedotti, Brito, Wikimedia commons MesserWoland, Szczepan 1990, Wikimedia commons Adopted from NIH and Eukaryotic Cells, CNX-bio-dev Web site. http://naginata.cnx.rice.edu:9090/content/m10005/latest/, Jan 30, 2013. Bacterial vs. Animal cells Bacterial Animal Cells Cell Genetic Nucleus material Genetic material Bacterial Cel l Prokaryote Animal Cel l Eukaryote Ivan Lanin, Wikimedia commons CDC, Public Health Image Library, http://phil.cdc.gov/phil/details.asp?pid=1048 Anatomy of a bacterium Cell Genetic Membranes Material (DNA) Flagellum Cell Wall Anatomy of a bacterium Gram negative Gram positive Y Tambe, Wikimedia commons Anatomy of a bacterium Cell Membranes Genetic Material All parts are made up (DNA) of different molecular Flagellum building blocks Cell Wall Gene Protein Thomas Splettstoesser, Wikimedia commons Dcirovic, Wikimedia commons

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Genetic. Material. (DNA). Flagellum. Cell Wall. Cell Membranes. Anatomy of a bacterium. All parts are made up of different molecular building blocks. Sugars

Final Antibiotic Resistance lecture - Harvard University PDF

121 Pages·2013·45.08 MB·English

by Amy Gilson

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Genetic. Material. (DNA). Flagellum. Cell Wall. Cell Membranes. Anatomy of a bacterium. All parts are made up of different molecular building blocks. Sugars

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Author:	Amy Gilson
Publication Year:	2013
Pages:	121
Language:	English
File Size:	45.08
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