Emerging nanotechnologies for diagnostics, drug delivery and medical devices

418 Pages·2017·5.57 MB·English

by  Cholkar

EMERGING
NANOTECHNOLOGIES
FOR DIAGNOSTICS,
DRUG DELIVERY, AND
MEDICAL DEVICES
This page intentionally left blank
EMERGING
NANOTECHNOLOGIES
FOR DIAGNOSTICS,
DRUG DELIVERY, AND
MEDICAL DEVICES
Editedby
ASHIM K. MITRA
KISHORE CHOLKAR
ABHIRUP MANDAL
Elsevier
Radarweg29,POBox211,1000AEAmsterdam,Netherlands
TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom
50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates
Copyright(cid:1)2017ElsevierInc.Allrightsreserved.
Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronic
ormechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,without
permissioninwritingfromthepublisher.Detailsonhowtoseekpermission,further informationabout
thePublisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyright
ClearanceCenterandtheCopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/
permissions.
Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythe
Publisher(otherthanasmaybenotedherein).
Notices
Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperience
broadenourunderstanding,changesinresearchmethods,professionalpractices,or medicaltreatment
maybecomenecessary.
Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingand
usinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformation
or methodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesfor
whomtheyhaveaprofessionalresponsibility.
Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assume
anyliabilityforanyinjuryand/ordamagetopersonsor propertyasamatterofproductsliability,
negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions,or ideas
containedinthematerialherein.
LibraryofCongressCataloging-in-PublicationData
AcatalogrecordforthisbookisavailablefromtheLibraryofCongress
BritishLibraryCataloguing-in-PublicationData
AcataloguerecordforthisbookisavailablefromtheBritishLibrary
ISBN:978-0-323-42978-8
For informationonallElsevierpublicationsvisitourwebsiteat
https://www.elsevier.com/books-and-journals
Publisher:MatthewDeans
AcquisitionEditor:SimonHolt
EditorialProjectManager:SabrinaWebber
ProductionProjectManager:LisaJones
Designer:GregHarris
TypesetbyTNQBooksandJournals
CONTENTS
ListofContributors ix
EditorBiographies xi
1. Therapeutic Applications of PolymericMaterials 1
KishoreCholkar,GayathriAcharya,HoangM.Trinh,GagandeepSingh
1. Introduction 1
2. PolymersasDrugDeliverySystems 2
3. PolymersinImagingandDiagnosis 8
4. Conclusion 15
References 15
2. Multifunctional Micro- and Nanoparticles 21
RubiMahato
1. Introduction 21
2. Micro-andNanomaterialsintheSynthesisofMultifunctionalCarriers 27
3. TypesofFunctionalMoieties 32
4. FunctionalizationofMicro-andNanoparticles 35
References 39
3. Nanomicelles in Diagnosis andDrug Delivery 45
HoangM.Trinh,MaryJoseph,KishoreCholkar,RanjanaMitra,AshimK.Mitra
1. Introduction 45
2. NanomicellePreparation 46
3. ApplicationofNanomicelleinDiagnosticsandImaging 48
4. ApplicationofNanomicellesinDrugDelivery 50
5. Conclusion 53
References 54
4. Diagnosis and Drug Delivery to the Brain: Novel Strategies 59
AbhirupMandal,RohitBisht,DhananjayPal,AshimK.Mitra
1. Introduction 60
2. BarriersforBrainDrugDelivery 60
3. PhysiologyoftheBloodeBrainBarrier 60
4. InvasiveDrugDeliveryApproaches 62
5. NoninvasiveDrugDeliveryApproaches 64
v
vi Contents
6. NanotechnologyApproaches 67
7. ActiveBloodeBrainBarrierTargetingStrategies 69
8. NovelNanoplatformsandDeliveryVehiclesforBBBTargeting 73
9. DevelopmentofNeurodiagnosticNanoimagingPlatforms 74
10. Conclusion 77
Acknowledgment 79
References 79
5. Emerging Nanotechnologyfor StemCell Therapy 85
VarunKhurana,DeepKwatra,SujayShah,AbhirupMandal,AshimK.Mitra
1. Introduction 85
2. ApplicationofNanoparticlesinIsolationofStemCells 86
3. ApplicationofNanoparticlesinStemCellTracking 89
4. RoleofNanotechnologyinRegulatingMicroenvironmentofStemCells:Potential
RolesinTissueEngineering 93
5. NanoparticlesasMacromolecularDeliverySystemsforStemCells 96
6. FutureProspectsandChallengesFacingtheField 100
References 100
6. Nanoparticulate Systems for Therapeutic and DiagnosticApplications 105
RajashekarKammari,NanditaG.Das,SudipK.Das
1. Introduction 105
2. WhyNanotechnologyandNanomedicine? 106
3. TypesofNanoparticlesinDrugDelivery 108
4. Conclusion 138
References 138
7. Peptide and Protein-Based Therapeutic Agents 145
MaryJoseph,HoangM.Trinh,AshimK.Mitra
1. Introduction 146
2. ChallengesWithPeptideandProteinTherapeutics 147
3. ChemicalModifications 147
4. Micro-andNanotechnologyforBiologicsinDrugDelivery 150
5. Protein-andPeptide-BasedTherapeutics 155
6. Conclusion 161
References 161
8. Nanotechnology in Intracellular Trafficking, Imaging, and Delivery
ofTherapeutic Agents 169
AnimikhRay,AshimK.Mitra
1. Introduction 169
2. Mechanisms 171
Contents vii
3. Macropinocytosis 173
4. Conclusion 185
References 185
9. Electrospun Nanofibers in Drug Delivery: Fabrication, Advances,
and Biomedical Applications 189
VibhutiAgrahari,VivekAgrahari,JianingMeng,AshimK.Mitra
1. Introduction 190
2. Stimuli-ResponsiveNanofibersinDrugDeliveryApplications 195
3. ApplicationsofElectrospunNanofibers 201
4. Conclusion 210
References 211
10. Nanosystems for DiagnosticImaging, Biodetectors, and Biosensors 217
GayathriAcharya,AshimK.Mitra,KishoreCholkar
1. Introduction 217
2. NanosystemsasPlatformsforAdvancedDiagnosticImaging 218
3. DiagnosticImagingWithNanosystems 226
4. BiologicalSensors 232
5. Conclusions 244
References 244
11. Micro- and Nanotechnology-Based Implantable Devices and Bionics 249
RohitBisht,AbhirupMandal,AshimK.Mitra
1. Introduction 249
2. BiocompatibilityIssuesofImplants 252
3. Microtechnology-BasedImplantableDevicesandBionics 258
4. Nanotechnology-BasedImplantableDevicesandBionics 272
5. ConclusionsandFuturePerspectives 280
References 281
12. Solid Lipid Nanoparticles in Drug Delivery:Opportunities andChallenges 291
AmeyaDeshpande,MajradMohamed,SaloniB.Daftardar,MeghaviPatel,
SaiH.S.Boddu,JerryNesamony
1. Introduction 292
2. ComponentsofSolidLipidNanoparticles 293
3. SolidLipidNanoparticleProductionTechniques 295
4. Drug-LoadingCapacityofSolidLipidNanoparticles 298
5. DrugIncorporationModelsofSolidLipidNanoparticles 299
6. DrugReleaseFromSolidLipidNanoparticles 300
7. ApplicationsofSolidLipidNanoparticlesforDrugDelivery 302
8. StabilityConcernsofSolidLipidNanoparticles 310
viii Contents
9. ToxicityAspectsofSolidLipidNanoparticles 319
10. DiagnosticApplicationsofSolidLipidNanoparticles 320
11. InVivoFateofSolidLipidNanoparticles 321
12. Conclusions 322
References 323
13. Microneedles in Drug Delivery 331
RubiMahato
1. Introduction 331
2. SkinStructureandBarriertoTransdermalDelivery 331
3. Microneedles 333
4. SelectionofMicroneedleDesignsforApplications 346
5. CommercialMicroneedleDevices 346
References 349
14. Nanotechnology-BasedMedicalandBiomedical Imaging for Diagnostics 355
KishoreCholkar,NupoorD.Hirani,ChandramouliNatarajan
1. Introduction 355
2. Fluorescence-BasedImagingandDiagnostics 356
3. NanocarriersinBiologicalImaging 359
4. PhotoacousticandUltrasoundImaging 367
5. Conclusions 369
References 370
15. Drug andGeneDelivery Materials andDevices 375
Ann-MarieAko-Adounvo,BeatrizMarabesi,RayssaCostaLemos,
AyukPatricia,PradeepK.Karla
1. Introduction 375
2. AdvancesinDeliverySystems 376
3. GeneDelivery 383
4. GeneTherapyProducts 385
5. ConclusionandFutureDirection 385
Acknowledgment 386
References 386
Index 393
LIST OF CONTRIBUTORS
GayathriAcharya
GlaxoSmithKline, Collegeville, PA, United States
Vibhuti Agrahari
University of MissourieKansas City,Kansas City, MO, United States
Vivek Agrahari
University of MissourieKansas City,Kansas City, MO, United States
Ann-MarieAko-Adounvo
Howard University, Washington, DC, United States
Rohit Bisht
University of Auckland, Auckland, New Zealand
SaiH.S. Boddu
TheUniversity of Toledo Health ScienceCampus, Toledo, OH, United States
Kishore Cholkar
Ingenus Pharmaceuticals/RiconPharma LLC, Denville,NJ, United States
Saloni B.Daftardar
TheUniversity of Toledo Health ScienceCampus, Toledo, OH, United States
Nandita G.Das
Butler University, Indianapolis, IN,United States
Sudip K.Das
Butler University, Indianapolis, IN,United States
Ameya Deshpande
TheUniversity of Toledo Health ScienceCampus, Toledo, OH, United States
Nupoor D.Hirani
Ingenus Pharmaceuticals/RiconPharma LLC, Denville,NJ, United States
Mary Joseph
University of MissourieKansas City,Kansas City, MO, United States
Rajashekar Kammari
Butler University, Indianapolis, IN,United States
Pradeep K. Karla
Howard University, Washington, DC, United States
Varun Khurana
Nevakar LLC, Bridgewater, NJ, United States
ix