Table Of ContentEFFECTS OF
ANTIDEPRESSANTS
Edited by Ru-Band Lu
EFFECTS OF
ANTIDEPRESSANTS
Edited by Ru-Band Lu
Effects of Antidepressants
Edited by Ru-Band Lu
Published by InTech
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Copyright © 2012 InTech
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First published June, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Effects of Antidepressants, Edited by Ru-Band Lu
p. cm.
ISBN 978-953-51-0663-0
Contents
Preface IX
Chapter 1 Evaluation of the Humoral Immune
Response of Wistar Rats Submitted to
Forced Swimming and Treated with Fluoxetine 1
Eduardo Vignoto Fernandes,
Emerson José Venancio and Célio Estanislau
Chapter 2 Effects of Antidepressants on
Inhibitory Avoidance in Mice: A Review 23
Concepción Vinader-Caerols,
Andrés Parra and Santiago Monleón
Chapter 3 Participation of the Monoaminergic System in
the Antidepressant-Like Actions of Estrogens:
A Review in Preclinical Studies 47
Carolina López-Rubalcava, Nelly Maritza Vega-Rivera,
Nayeli Páez-Martínez and Erika Estrada-Camarena
Chapter 4 Antidepressants and Morphological
Plasticity of Monoamine Neurons 73
Shoji Nakamura
Chapter 5 Serotonin Noradrenaline
Reuptake Inhibitors (SNRIs) 91
Ipek Komsuoglu Celikyurt,
Oguz Mutlu and Guner Ulak
Chapter 6 Antidepressants Self-Poisoning in Suicide and
Suicide Attempt: Acute Toxicity and Treatment 109
Sara Santos Bernardes, Danielle Ruiz Miyazawa,
Rodrigo Felipe Gongora e Silva, Danielle Camelo Cardoso,
Estefânia Gastaldello Moreira and Conceição Aparecida Turini
Chapter 7 Rational Polypharmacy in
the Acute Therapy of Major Depression 131
Per Bech and Claudio Csillag
VI Contents
Chapter 8 Antidepressant Drugs and Pain 143
Blanca Lorena Cobo-Realpe, Cristina Alba-Delgado,
Lidia Bravo, Juan Antonio Mico and Esther Berrocoso
Chapter 9 Antidepressant Drug Use
in Patients with Diabetes Mellitus
Type 1 – The Effect of Medication on
Mental Problems and Glycemic Control 163
Jana Komorousová and Zdeněk Jankovec
Chapter 10 Effects of Fluoxetine and Venlafaxine on
the Salivary Gland – Experimental Study 181
Silvana da Silva,
Luciana Reis de Azevedo, Antônio Adilson Soares de Lima,
Beatriz Helena Sottile França, Maria Ângela Naval Machado,
Aline Cristina Batista Rodrigues Johann and
Ana Maria Trindade Grégio
Preface
Depression could be called the black death of the twenty-first century due to its high
prevalence (life time prevalence could be 10-15% or higher). It often occurs in people
during their middle age, 30-50 years old, and costs much because of the medical
resources used to treat it and the higher suicide and rate of recurrence. In addition,
people with depression are often comorbid with anxiety disorders and lack of efficient
treatment. Even for the patients with anxiety disorders, the most useful medications
are antidepressants.
From 1970 to 1990, antidepressants drug delivery has developed rapidly, including
monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs),
tetracyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs)
and serotonin-norepinephrine reuptake inhibitors (SNRIs), being the most
commonly used. These medications are among the most commonly prescribed
by psychiatrists and other physicians, and their effectiveness and adverse effects
are the subject of many studies and competing claims. As more studies are
carried out more evidence of the other effects of antidepressants have been
reported; antidepressants are no longer anti-depressant/mood only, but provide
other effects.
The editor tried to integrate various aspects of treatment for depression and the
effects of antidepressants. In recent years, more and more researchers are exploring
the mechanisms in psychiatry and psychopharmacology of treating psychiatric
illnesses. Some hypotheses have been challenged through various points of view,
but, the hypothesis on monoamine still plays an important role in treating
depression. From the viewpoint of traditional psychopharmacology, animal models
to clinical trials in humans, a comprehensive review was carried out to understand
the possible pathology of depression. In addition, the other therapeutic effects of
antidepressants, as well as side effects, are also reported in this book. Moreover,
psychotherapy has also been reported to have similar effects, especially
cognitive-behavioural therapy; these treatments are also reported to work for
depression. On the fundamental understanding of pharmacological effects and the
relationship with depression, the therapeutic effect of psychotherapy could be more
applicable.
X Preface
The editor tried to help the readers who are beginners in this field to have a
comprehensive and basic knowledge of antidepressants and further, have inspiration
for their future studies.
Ru-Band Lu
Department of Psychiatry, National Cheng Kung University & Hospital, Tainan,
Taiwan
