Dimethyl Sulfoxide (DMSO) in Trauma and Disease

258 Pages·2015·7.05 MB·English

by  Stanley W. Jacob

CHEMISTRY JA
C
O Dimethyl Sulfoxide
B
•
Dimethyl Sulfoxide D
E
L
A
T
O (DMSO) in Trauma
R
(DMSO) in Trauma R
E
and Disease and Disease
First isolated as a chemical compound by a Russian chemist in 1866,
dimethyl sulfoxide (DMSO) proved to be a near-perfect solvent for
decades before its remarkable biological and medical activities were
discovered. DMSO is one of the most prodigious agents ever to come
out of the world of drug development. Its wide range of biological actions
involving plants, animals, and humans has led to the publication of tens
of thousands of articles in the scientific literature.
Dimethyl Sulfoxide (DMSO) in Trauma and Disease examines the major
clinical uses of DMSO in humans as supported by basic evidence derived
from experiments in animals, including its effects in disorders such as
osteoarthritis, interstitial cystitis, gastrointestinal inflammatory changes,
scleroderma, respiratory distress, myasthenia gravis, cardiac disease,
traumatic brain injury, and Alzheimer’s disease.
The effects of DMSO on pain, cancer, stroke, and spinal cord injury are
also discussed. The book explores how its chemical structure is able
to react and deactivate toxic molecules generated by DNA damage, free
radical formation, inflammation, oxidation, and infection. For the first time,
the collective data on the biological, chemical, and medical actions of
DMSO are presented and analyzed from the published scientific literature.
Clearly written, the book incorporates easy-to-understand scientific
descriptions that appeal both to health care professionals and the
millions of people worldwide who have used DMSO for an assortment of
STANLEY W. JACOB
ailments as a prescriptive or off-label medication.
JACK C. DE LA TORRE
K25303
ISBN: 978-1-4987-1467-9
90000
9 781498 714679
K25303_Cover_PubGr.indd All Pages 2/11/15 2:38 PM

Dimethyl Sulfoxide
(DMSO) in Trauma
and Disease

Dimethyl Sulfoxide
(DMSO) in Trauma
and Disease
STANLEY W. JACOB
JACK C. DE LA TORRE
CRC Press
Taylor & Francis Group
6000 Broken Sound Parkway NW, Suite 300
Boca Raton, FL 33487-2742
© 2015 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20150209
International Standard Book Number-13: 978-1-4987-1468-6 (eBook - PDF)
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Contents
Foreword ...................................................................................................................ix
Authors ......................................................................................................................xi
Introduction ............................................................................................................xiii
Chapter 1 Chemistry of DMSO ............................................................................1
Chemical Structure and Properties of DMSO .....................................1
DMSO Solvation and Chemical Activity .............................................3
Protein Folding .....................................................................................4
Permeability Enhancement ..................................................................4
DMSO as a Chemical Chaperone ........................................................5
DMSO as an Electrolyte .......................................................................8
Cryoprotection ......................................................................................9
DMSO in the Sea and the Atmosphere ..............................................10
References ..........................................................................................11
Chapter 2 DMSO in Basic Pharmacology ..........................................................15
Absorption, Fate, and Excretion of DMSO ........................................15
Penetration ..........................................................................................16
Chemical Chaperones ........................................................................16
DMSO as a Pain Medication ..............................................................17
Anti-Inflammatory .............................................................................21
Prostaglandins ....................................................................................21
Cardiac Disease ..................................................................................24
Ulcerative Colitis ................................................................................28
Skin Penetrant ....................................................................................29
Wound Healing ...................................................................................29
Burns and Scar Tissue ........................................................................30
Respiratory Stimulation .....................................................................32
Acute Respiratory Distress Syndrome ...............................................33
Experimental Blunt Chest Trauma .....................................................34
Autophagy ..........................................................................................35
Diuresis ...............................................................................................36
Cholinesterase Inhibition ...................................................................36
Solvent Action ....................................................................................37
Veterinary Uses ..................................................................................37
Teratology and LD ...........................................................................38
50
Ocular Effects.....................................................................................39
Intrawound Administration of DMSO ...............................................40
References ..........................................................................................40
v
vi Contents
Chapter 3 DMSO Clinical Pharmacology ..........................................................49
DMSO in Disease ...............................................................................49
Pain .....................................................................................................50
Interstitial Cystitis ..............................................................................59
Gastrointestinal Disorders ..................................................................61
Autoimmune Disorders ......................................................................61
Respiration .........................................................................................62
Amyloidosis and Scleroderma ............................................................62
Thromboembolic Events ....................................................................63
Platelet Deaggregation and Free Radical Scavenging ........................66
Tissue Factor and Inflammation .........................................................68
Clinical Toxicology ............................................................................70
References ..........................................................................................71
Chapter 4 DMSO in Genetics .............................................................................81
Protection from Ionizing Radiation ...................................................81
DMSO Protection of Single- and Double-Stranded DNA Breaks .....83
DMSO in Cellular Differentiation......................................................88
Cancer Stem Cells and Differentiation ..............................................92
References ..........................................................................................93
Chapter 5 DMSO in Basic Microbiology ............................................................99
DMSO in Bacterial Infections ............................................................99
Era of Antimicrobials ....................................................................99
DMSO and Pathogens ......................................................................101
DMSO in Viral and Fungal Pathology .............................................108
References ........................................................................................111
Chapter 6 DMSO in Clinical Microbiology ......................................................115
How Bacteria Achieve Antibiotic Resistance...................................115
DMSO in Multidrug-Resistant Tuberculosis ....................................116
References ........................................................................................121
Chapter 7 DMSO in Malignancy ......................................................................123
DMSO and Neoplasia .......................................................................123
Friend Leukemia Cells .....................................................................123
HL-60 Human Cell Line ..................................................................124
Metastatic Liver Disease ..................................................................125
DMSO Combined with Anticancer Agents ......................................126
DMSO in Extravasation ...................................................................127
Contents vii
Cancer and Radiation .......................................................................127
Onyx Embolization ..........................................................................128
References ........................................................................................129
Chapter 8 DMSO in Basic Neuroprotection .....................................................133
Brain Trauma Overview ...................................................................133
Secondary Injury and Ischemic Penumbral Neurons .......................135
DMSO in Experimental Brain Trauma ............................................137
Free Radicals in Brain Injury ...........................................................144
Cerebral Hemodynamic Function in Brain Injury ...........................146
Prostaglandins ..................................................................................148
Tissue Factor ....................................................................................151
Cerebral Blood Flow ........................................................................153
Concussions ......................................................................................154
DMSO in Brain Concussion .............................................................157
DMSO Combined with a Glycolytic Intermediate ...........................157
DMSO in Experimental Brain Ischemia ..........................................160
Ethical Considerations for Using Nonhuman Primates
in CNS Injuries .................................................................................163
Role of DMSO in Experimental Stroke ...........................................164
DMSO in Missile Injury to the Brain...............................................172
DMSO Compared to Mannitol in Missile Injury .............................176
DMSO in Aging Research ................................................................176
DMSO in Experimental Dementia ...................................................178
DMSO in Experimental Spinal Cord Injury ....................................182
DMSO as a Solvent ..........................................................................187
References ........................................................................................188
Chapter 9 DMSO in Clinical Neuroprotection .................................................203
Overview of Clinical Traumatic Brain Injury ..................................203
Head Injury in Children ...................................................................207
Cost and Consequences of Traumatic Brain Injury .........................207
Chronic Traumatic Encephalopathy .................................................208
Treating Traumatic Brain Injury ......................................................209
DMSO in Traumatic Brain Injury ....................................................211
Optimal DMSO Dose for Traumatic Brain Injury ...........................214
Comparing DMSO Doses, Duration of Treatment, and Use as a
First- or Second-Line Treatment for Traumatic Brain Injury ..........216
DMSO in Intracranial Aneurysm Hemorrhage ................................221
DMSO Compared to Progesterone for Traumatic Brain Injury .......224
DMSO + Fructose-1,6-Disphosphate (FDP) for Ischemic Stroke ....227
References ........................................................................................231