Curriculum Vita STEVEN ALLAN SOPER

45 Pages·2011·0.54 MB·English

Curriculum Vita
STEVEN ALLAN SOPER
MAILING
ADDRESS:
Department of Biomedical Engineering 11855 Villa Creek Ave.
University of North Carolina, Chapel Hill Baton Rouge, LA 70810
Chapel Hill, NC [phone]
225-578-1527
225-578-3458 (FAX)
Internet: [email protected]
GROUP WEB SITE: http://chemistry.lsu.edu/chem/facultypages/soper/soper.html
EDUCATION:
Los Alamos National Laboratory, Los Alamos, NM, 10/89 - 9/91, postdoctoral
fellow under the direction of Dr. Richard A. Keller
The University of Kansas, Lawrence, KS, 9/85-9/89, Ph.D., Bioanalytical
Chemistry, Dr. Theodore Kuwana, research advisor
University of Nebraska at Omaha, Omaha, NE, 9/80 - 5/82, B.A., Chemistry
University of Nebraska at Omaha, Omaha NE, 9/75 - 5/80, B.S., Psychology
PROFESSIONAL
EXPERIENCE:
University of North Carolina, Chapel Hill, Professor, Dept. of Biomedical
Engineering, Chapel Hill, NC, 2011 – Present
University of North Carolina, Chapel Hill, Professor, Dept. of Chemistry, Chapel
Hill, NC, 2011 – Present
World Class University Professor, Ulsan National Institute of Science &
Technology, Ulsan, South Korea, 2009-2012
Visiting Scientist, University of North Carolina, Chapel Hill (Sabbatical Leave),
Fall, 2008
Director, Center for BioModular Multi-Scale Systems, Spring, 2004 – Present
Louisiana State University, Baton Rouge, LA, Dept. of Mechanical Engineering,
9/2004 – 9/2011, Professor of Mechanical Engineering
Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/2002 –
9/2011, William L. & Patricia Senn, Jr. Professor of Chemistry
Louisiana State University, Baton Rouge, LA, Dept. of Biological Sciences,
9/2001 – 9/2011, Adjunct Faculty
Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/2001 -
Present, Professor of Chemistry
Visiting Scholar, Baylor College of Medicine (Sabbatical Leave), Fall, 1998
Louisiana State University, Baton Rouge, LA, Dept. of Chemistry, 9/97 – 8/2001,
Associate Professor of Chemistry
Louisiana State University, Baton Rouge, La, Dept. of Chemistry, 9/91 - 8/97,
Assistant Professor of Chemistry
Science Advisor, Food and Drug Administration, Southeast Region, 10/92-9/97
Los Alamos National Laboratory, Los Alamos, NM, 10/89 - 9/91, Postdoctoral
fellow in Chemical and Laser Sciences division
The University of Kansas, Lawrence, KS, 9/86 - 12/87, Teaching assistant,
advanced Analytical Chemistry
The University of Kansas, Lawrence, KS, 9/85 - 5/86, Teaching assistant,
general Chemistry
Colgate Palmolive Co. Kansas City, KS, 9/83 - 9/85, Analytical Chemist
Soper, Steven A.
AWARDS &
HONORS:
American Chemical Society; Advances in Chemical Instrumentation, 2011
Fellow, Society for Applied Spectroscopy, 2010
Fellow, Royal Society of Chemistry, 2010
Fellow, American Association for the Advancement of Science, 2010
Rainmakers – LSU Top 100 Researchers, Louisiana State University, 2009
Rainmakers – LSU Top 100 Researchers, Louisiana State University, 2008
Distinguished Research Master, Louisiana State University (Top Research
Award Offered by the University), May 2008
Society for Applied Spectroscopy Tour Speaker, 2007
A.A. Benedetti-Pichler International Microchemical Award, November, 2006
Distinguished Faculty Award, Louisiana State University, April, 2004
William L. & Patricia Senn, Jr. Professor of Chemistry, August 2002-present
Society for Applied Spectroscopy Tour Speaker, 2002
Charles E. Coates Award for Outstanding Contributions to Chemical/Engineering
Research in Louisiana, 2001
Outstanding Untenured Researcher (Physical Sciences), Phi Kappa Phi,
Louisiana State University, 1996
Outstanding Researcher, College of Basic Sciences, Louisiana State University,
1995
Whitaker Foundation Award, Whitaker Bioengineering Research Foundation,
1995
Shannon Award, National Institutes of Health (National Human Genome
Research Institute), 1994
R & D 100 Award, Single Molecule Detection Device, 1992
National ACS Fellowship (sponsored by the Pittsburgh Conference), 1989
Higuchi Distinguished Doctoral Candidate Award, The University of Kansas,
1989
KU Graduate School Summer Fellowship, The University of Kansas, 1989
Phillips/McCollum Research Award, The University of Kansas, 1988
H.P. Cady Award, The University of Kansas, 1986
Bailey Fellowship, The University of Kansas, 1985
JOURNAL ADVISORY/EDITORIAL
BOARD:
Journal of Fluorescence, 1996 – present
Single Molecules, Advisory Board, 2000 – 2004
The Analyst, Advisory Board, 2000 - 2008
Analytical Chemistry, A-Page Advisory Board, 2003 – 2006
The Analyst, International Editorial Board, 2008 – 2009
The Analyst, Editor for the Americas, 2010 - present
Journal of Micro- and Nanosystems, Advisory Board, 2008 - present
STUDY PANELS:
National Institutes of Heatlh, Integrated Molecular Analysis Study Panel (NCI),
November, 2011
National Institutes of Health, Bioanalytical Systems Study Panel, June, 2011,
Chair
National Institutes of Health, Integrated Systems Development Study Panel,
January, 2011
National Institutes of Heatly, Integrated Systems Development Study Panel,
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Soper, Steven A.
June, 2011

National Institutes of Health, Integrated Systems Development Study Panel,
October, 2009, Chair
National Institutes of Health, Integrated Systems Development Study Panel,
September, 2009
National Cancer Institute, NIH Review panel for IMAT Program, July, 2009
Life Sciences Discovery Fund Review Panel, AAAS, June, 2009
Chair, Center for Scientific Review, P41 Site visit panel, August, 2008
National Center for Research and Resources, Biomedical Instrumentation, June,
2008
Chair, Center for Scientific Review, NIH Panel for K99 Fellowships, October 2007
National Center for Research and Resources, Biomedical Instrumentation, June,
2007
National Institute of General Medicine, K99 Special Emphasis Panel, March 2007
Chair, NIBIB (National Institutes of Health) Special Emphasis Panel, November,
2006
Chair, NIBIB (National Institutes of Health) Quantum Projects, July, 2006
Chair, NCI (National Institutes of Health) Point-of-Care Technologies, March,
2006
Bioengineering and Science Technology (Instrumentation and Systems
Development, ISD) Study Panel, National Institutes of Health, 2004 – 2006
(permanent member)
Human Genome Panel, National Institutes of Health, 2003 - 2004 (permanent
member)
National Cancer Institute Special Study Section, National Institutes of Health,
7/00; 4/01; 7/01; 2/02 (ad hoc member)
National Human Genome Study Section, National Institutes of Health, 6/95; 2/97
(ad hoc member)
Metallobiochemistry Study Section, National Institutes of Health, 6/98; 6/99; 2/00
(ad hoc member)
Human Genetics SBIR Special Panel, National Institutes of Health, 5/96; 7/97;
2/98; 7/99; 11/00; 12/00 (ad hoc member)
Environmental Management Study Panel, Department of Energy, 8/96; 9/97
(Committee Chair) (special study section)
Shared Instrumentation Study Section, National Science Foundation, 8/98 (ad
hoc member)
Shared Instrumentation Study Section (Human Genetics), National Institutes of
Health, 10/98 (ad hoc member)
Breast Cancer Special Program, Department of Defense (U.S. Army), 4/98 (ad
hoc member)
PROFESSIONAL
ACTIVITIES:
American Chemical Society, Analytical Division
Society for Applied Spectroscopy
American Association for the Advancement of Science
Royal Society of Chemistry, RSC
RESEARCH
INTERESTS:
Development of micro-/nanofabricated biochemical analysis systems for high
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Soper, Steven A.
throughput applications; novel fabrication methods for personalized medicine;
single-molecule fluorescence spectroscopy; dye photophysics and
photochemistry; bioanalytical applications of near-infrared fluorescence;
development of novel detection schemes for DNA and protein analysis; ultra-high
throughput screening for drug discovery.
NOTEWORTHY
ACTIVITIES:
Director, Center for BioModular Multi-Scale Systems (CBM2), 2003 – present, funded by the
NSF ($14,800,000 for 2003 – 2010). The Center is a highly interdisciplinary unit composed of 17
research activity faculty situated in 4 different institutions within the State of Louisiana and
collaborators at several renowned institutions (Cornell Medical College, Baylor College of
Medicine and Sloan Kettering Memorial Cancer Institute). The Center has 3 major missions: (1)
Build a nationally competitive Center of Excellence; (2) develop strong ties with the private
sector through collaborative research and foster new start-up companies; and (3) maintain a
highly engaging K-20 program to educate a new work force and to inform the general public on
new scientific/engineering discoveries being made at LSU and how they are used in medicine.
The Center was recently invited to submit a full-proposal to the National Science Foundation as
part of their Engineering Research Center (ERC) competition (PI for the grant is Prof. Soper).
Of 165 pre-proposal submissions, CBM2 was one of 34 invited to submit a full proposal. The
proposal would have provided $25.5M (direct costs) in funding including matches from the
Board of Regents and LSU. The partners in this proposal were University of Texas, Arlington;
University of Massachusetts, Lowell; University of Southern Mississippi; Northeastern
University; Xavier University; and Cornell Medical College. Units on the LSU campus that are
participating include Chemistry, Mechanical Engineering, Chemical Engineering, Physics,
Stephenson Entrepreneurship Institute, Center for Advanced Microstructures and Devices and
the Center for Computational Technology. The Center proposal was not selected for funding,
but received highly encouraging reviews. It has been re-packaged for resubmission to the ERC
program at NSF. Another pre-proposal was submitted in July, 2009.
CBM2 and CAMD service for the BioMEMS Research and technology building operated
community by providing fabrication by CBM2 for carrying out its various
capabilities for both academia and the missions. The building is a 35,000 sq. ft.
private sector using the tools and expertise facility with laboratories, conference rooms
available at LSU. Shown is the booth set up and offices. The building is also used for
at the 2005 µTAS show at Boston, MA. various outreach activities.
Research Mission of CBM2. The program consists of 17 research activity faculty with
approximately 107 graduate students and 34 post-doctoral associates. As a group, the Center’s
faculty produces nearly 200 peer-reviewed publications per year and generates $45M in
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Soper, Steven A.
extramural research per year. The research mission of the Center is, “Engage a diverse group
of scientists, engineers and clinicians in the delivery of new technologies that will provide
unprecedented capabilities for medicine, basic biology, drug discovery and homeland security.”
To facilitate collaborative efforts between Center participants, a BioMEMS working group
meeting was created by Prof. Soper, which meets once a month during the academic year.
Industrial Outreach Mission of CBM2. The Center has a full-time industrial liaison that has
facilitated the generation of joint research opportunities with a variety of private sector
companies, such as Agilent, Microsystems Biotechnology, Inc., Reliagene and Li-COR
Biotechnology. In addition, a small company has emerged from the Center, BioFluidica
Microtechnologies, which was founded by Prof. Soper and is populated with various associates
serving as the company’s administrative branch and technical workforce.
Educational Mission of CBM2. The Center, through efforts of Prof. Soper, have developed a
variety of outreach programs that service the K-12 community of students, such as C3
(Chemistry, Concepts and Connections – high school students and their teachers), and Girl
Scout Summer Camps (now sponsored by Exxon). These programs service nearly 400 students
per year of which 30% are from underrepresented groups. In addition, research experience for
undergraduate programs have been spawned by the Center and professional development
workshops for graduate students (writing and communication skills, functioning in an
interdisciplinary research environment, interviewing skills and entrepreneurial skills). Recently, a
Research Experience for Teachers (NSF-RET) has been successfully funded by the Center.
Chair – Gordon Research Conference on Bioanaltyical
Sensors (2012). Bioanalytical sensors play an integral
role in managing a number of diseases in terms of
diagnosis, prognosis and selecting and tracking the
efficacy of therapeutic regimens. Highly novel and
unpublished research was presented and freely
discussed at the 2012 Bioanalytical Sensors Gordon
Research Conference and Gordon-Kenan Graduate
Research Seminar cutting across a number of enabling
technologies including materials, molecular recognition,
micro-/nanosystems, optical/electrochemical
transducers and the utility of biosensors for monitoring a host of diseases. Soper arranged the
program and wrote several grants (NIH, NSF) to support this meeting.
Biosensors Workshop (Sponsored by the NIH). Prof.
Soper chaired a NIH (National Cancer Institute) workshop
focused on the use of biosensors for the management of
cancer-related diseases. This workshop resulted in the
formulation of a white paper that was used to spawn a
program solicitation focused on the development of
biosensors for the diagnosis/prognosis of cancer. The
workshop had over 250 participants and was attended by
program officers at the NCI and NIH.
Cluster Hire and Governor’s Biotechnology Initiatives.
Authored two grant proposals focused on recruiting new
faculty (9 total) into highly interdisciplinary research initiatives on the LSU campus. The
Governor’s Biotechnology program resulted in two faculty lines, one in Chemistry and another in
Mechanical Engineering (see list below). The Cluster Hire Initiative will produce 7 new faculty
lines with a research focus in the area of the design, synthesis, characterization and
applications of soft materials, in particular high performance, nano-scale polymeric materials.
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Soper, Steven A.
1. Governor’s Biotechnology Initiative
a. Prof. Samuel D. Gilman, Department of Chemistry, Louisiana State University,
Electrokinetic flow manipulation using electric fields
b. Prof. Sunggook Park, Department of Mechanical Engineering, Louisiana State
University, Nanoimprint Lithography for the fabrication of enabling tools in biology and
medicine
2. Multidisciplinary Hiring Initiative (as of 9/15/08)
a. Prof. Mark Jarrell, Department of Physics, Louisiana State University, Computational
simulations of highly correlated materials
b. Four faculty are currently being recruited to LSU as part of this hiring initiative.
Bioengineering Research Partnership (BRP) Grant: PI on a grant project funded by the National
Institutes of Health as part of their new BRP program. The effort was an interdisciplinary project
between LSU, Cornell Medical College and Sloan Kettering Memorial Cancer Institute. The BRP
grant was focused on developing enabling tools for mutation analysis and resulted in 55 peer-
reviewed publications over a 6 year funding period. Participants included materials scientists,
molecular biologists, clinicians, organic chemists, mechanical engineers and bioanalytical
chemists.
Analytical Chemistry Cover: Composed an article in the premier journal of
analytical chemistry, Analytical Chemistry (Anal. Chem. 72 (2000) 642A-
651A). The article appeared in the A-page section of this journal and
focused on polymer-based microfluidics.
University-wide professional development seminar series for graduate
students. Prof. Soper developed a monthly seminar series directed for
university-wide graduate students engaged in science and technology
research. The seminar series includes talks focused
toward developing skills in technical writing, entrepreneurial endeavors,
collaborative and interdisciplinary research, and professional networking.
The Analyst Cover: In January 2009, our research was
highlighted on the cover of this journal (Analyst 134 (2009)
97-106). This work dealt with single molecule detection
configured in a high throughput format with applications in
such areas as drug discovery. This article was noted as the
most downloaded article in the Analyst as of April, 2009.
Electrophoresis Cover: In December 2008, our work appearing in that issue
was featured as the cover page. The work was entitled, “Generating High Peak Capacity 2-
Dimensional Maps of Complex Proteomes Using Poly(methyl methacrylate) Microchip
Electrophoresis. Electrophoresis 29 (2008) 4984 – 4992.
Journal of Mass Spectrometry Cover: For the April 2009 issue of this journal, Prof. Soper
collaborated with Prof. Kermit Murray on interfacing MALDI-MS to microchip solid-phase
bioreactors and this work was featured on the cover of this issue. The article was entitled,
“Development of an Automated Digestion and Droplet Deposition Microfluidic Chip for MALDI-
TOF MS.” J. Am. Soc. Mass Spectrosc. 19 (2008) 964-972.
Funding history in the Departments of Chemistry and Mechanical Engineering. Prof. Soper has
been very productive in generating major funding for projects with collaborators across the
university, but in particular the Department of Chemistry and the Department of Mechanical
Engineering. Shown below is the total funding (granted) for Chemistry showing the impact that
Prof. Soper and his colleagues have had on improving the visibility of this department. Soper
has received funding from the private sector, state agencies and the federal government (NIH
and NSF). His total funding revenues have exceeded $39M during his tenure at LSU.
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Soper, Steven A.
Graduate Student Education: Has produced 31
Ph.D. candidates (as of 08/31/11), with 3
students receiving national awards (Li Zhu, Pfizer
Fellowship, UpJohn 1-year Fellowship; Annie
Obuabafo, Pfizer Fellowship). Andre Adams was
the organizer of the student symposium for the
Gordon Conference on Biosensors). Also initiated
a new program for providing entrepreneurial
training to graduate students in conjunction with
the Stephenson’s Entrepreneurial Institute.
Young Investigators Special Issue in The Analyst:
Initiated a special issue in this journal that
focuses on research presentations in the form of
manuscripts by new faculty (<2 years of service
as a faculty member) in
Soper in a laser research laboratory with
the area of analytical
graduate students Suzanne Lassiter (Ph.D.,
2001) and Musundi Wabuyele (Ph.D., sciences. The inaugural
2003). issue appeared in 2001
and consisted of
contributions from 13 researchers across North America. This
program has continued in this journal.
Analytical Biosensors Gordon Conference. Prof. Soper in 2008
was elected as the Vice-Chair for the 2010 Gordon Research
Conference on Biosensors. In the 2012 meeting, he will serve
as the Chair of this Gordon Research Conference.
Soper presents Intellectual property
information to students at a 2006 Student
Symposium Series Workshop. Pictured
with Soper is Mayor-President Kip Holden
of Baton Rouge, who discussed with
students at the Student Symposium
Series Workshop the role of technology in
community developmental efforts (July,
2006).
Publications. Soper’s total publication number (as of 08/31/11) is 250, which includes journal
articles, books, patents and conference proceedings. Soper’s h-index (as calculated by the Web
of Science, which does not include engineering publications) is 40 with a total number of
citations being 4,535 (h-slope = 1.91). Of the publications emanating since his academic
appointment at LSU (1991), nearly 72% have multiple faculty authors indicating his
extraordinary interdisciplinary efforts.
Founder – BioFluidica Microtechnologies (2009). Soper founded this company to commercialize
devices for the selection of Circulating Tumor Cells (CTCs) from whole blood. This company
has now formed a merger with Emerscent LLC to further commercialization opportunities and
secure VC funding. The company has already received Phase I SBIR funding and is currently
writing a Phase II application with the NCI.
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Soper, Steven A.
REFEREED PUBLICATIONS:
1. Long Optical Path Length Thin Layer Cuvette Cells, Y. Gui, S.A. Soper and T. Kuwana,
Anal. Chem. 60 (1988) 1645-1648.
2. High Sensitivity Fluorescence Detection of NDA-Derivatized Primary Amines with a Low
Power He-Cd Laser for HPLC, S.A. Soper, S.M. Lunte and T. Kuwana, Anal. Sci. 5 (1989)
23-29.
3. Matrix-Isolated Luminescence of Primary Amines Derivatized with Naphthalenedialdehyde,
S.A. Soper and T. Kuwana, Appl. Spectrosc. 43 (1989) 883-886.
4. Matrix-Isolated Surface-Enhanced Raman Spectroscopy: The Role of the Supporting Matrix,
S.A. Soper and T. Kuwana, Appl. Spectrosc. 43 (1989) 1180-1187.
5. Nonlinear Surface-Enhanced Spectroscopy of Silver Colloids and Pyridine: Hyper-Raman
and Second-Harmonic Scattering, C.K. Johnson and S.A. Soper, J. Phys. Chem. 93 (1989)
7281-7285.
6. Thin Layer Chromatography Diskette Storage of High-Performance Liquid Chromatographic
Effluents with Off-Line Laser-Induced Fluorescence Detection, G. Strojek, S.A. Soper, K.
Ratzlaff and T. Kuwana, Anal. Sci. 6 (1990) 121-129.
7. The Intramolecular Loss of Fluorescence by Lysine Derivatized with
Naphthalenedialdehyde, S.A. Soper, S. Chamberlin, C.K. Johnson and T. Kuwana, Appl.
Spectrosc. 44 (1990) 858-863.
8. Surface-Enhanced Resonance Raman Spectroscopy of Liquid Chromatographic Analytes
on Thin-Layer Chromatographic Plates, S.A. Soper, K.L. Ratzlaff and T. Kuwana, Anal.
Chem. 62 (1990), 1438-1444.
9. Detection of Single Fluorescent Molecules, E.B. Shera, N.K. Seitzinger, L.M. Davis, R.A.
Keller and S.A. Soper, Chem. Phys. Lett. 174 (1990) 553-557. **This article has been
referenced 298 times as of 8/11.
10. Single Molecule Detection of R-6G in Ethanolic Solutions Utilizing CW Excitation, S.A.
Soper, J.H. Hahn, H.L. Nutter, E.B. Shera, J.C. Martin, J.H. Jett and R.A. Keller, Anal.
Chem. 63 (1991) 432-437
11. Laser-Induced Fluorescence Detection of Rhodamine 6G at 5 x 10-15 M, J.H. Hahn, S.A.
Soper, H.L. Nutter, J.C. Martin, J.H. Jett and R.A. Keller, Appl. Spectrosc. 45 (1991) 743-
746.
12. Rapid DNA Sequencing Based Upon Single Molecule Detection, E.R. Fairfield, J.H. Jett,
R.A. Keller, J.H. Hahn, L.A. Krakowski, B.L. Marrone, J.C. Martin, R.L. Ratliff, E.B. Shera
and S.A. Soper, Gen. Anal. 8 (1991) 1-7.
13. The Photophysical Constants of Several Visible Fluorescent Dyes and Their Effects on
Ultrasensitive Fluorescence Detection, S.A. Soper, E.B. Shera, L.M. Davis, H.L. Nutter and
R.A. Keller, Photochem. & Photobiol. 57 (1992) 972-977.
14. Detection and Identification of Single Molecules in Solution, S.A. Soper, L.M. Davis, E. B.
Shera, J. Opt. Soc. Am. B 9 (1992) 1761-1769.
15. Photon Burst Detection of Single Near-Infrared Fluorescent Dye Molecules, S.A. Soper,
Q.L. Mattingly and P. Vegunta, Anal. Chem. 65 (1993) 740-747. This article was featured in
Chemical and Engineering News Research Highlights (1993). Number of citations on this
article is 170 (since 8/11).
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Soper, Steven A.
16. Error Analysis of Simple Algorithms for Determining Fluorescence Lifetimes in Ultradilute
Dye Solutions, S.A. Soper and B.L. Legendre, Jr., Appl. Spectrosc. 48 (1994) 400-405.
17. Steady-state and Picosecond Laser Studies of Nonradiative Pathways in Tricarbocyanine
Dyes: Implications to the Design of Near-IR Fluorochromes with High Fluorescence
Efficiencies, S.A. Soper and Q.L. Mattingly, J. Am. Chem. Soc. 116 (1994) 3744-3752.
18. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectrometry, S.A.
Soper, L.B. McGowen and I.M. Warner, Anal. Chem. 66 (1994) 428R-444R.
19. Binary Solvent Effects in Capillary Electrophoresis with Ultrasensitive Near-IR Fluorescence
Detection of Related Tricarbocyanine Dyes and Dye-Labeled Amino Acids, J.H. Flanagan,
B.L. Legendre, Jr., R.P. Hammer and S.A. Soper, Anal. Chem. 67 (1994) 341-347.
20. Determination of Partition Coefficients and Photophysical Properties of Near-Infrared
Fluorescent Dyes in Organized Media Using Single Molecule Monitoring, S.A. Soper, B.L.
Legendre, Jr. and J. Huang, Chem. Phys. Lett. 237 (1995) 339-345.
21. Ultrasensitive Near-IR Fluorescence Detection for Capillary Gel Electrophoresis and DNA
Sequencing Applications, D.C. Williams and S.A. Soper, Anal. Chem. 67 (1995) 3427-3432.
22. On-Line Fluorescence Lifetime Determinations During Capillary Electrophoresis, S.A.
Soper, B.L. Legendre, Jr. and D.C. Williams, Anal. Chem. 67 (1995) 4358-4365.
23. Single Molecule Detection in the Near-IR: Applications in Chemistry and Biochemistry, S.A.
Soper, B.L. Legendre and D.C. Williams, Exp. Techn. Phys. 41 (1995) 167-182.
24. Spectroscopic and Binding Properties of Tricarbocyanine Dyes Bound to Double-Stranded
DNA, Y. Davidson, B. Gunn and S.A. Soper, Appl. Spectrosc. 50 (1996) 211-221.
25. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectroscopy, I.M.
Warner, S.A. Soper and L.B. McGowen, Anal. Chem. 68 (1996) 73R-91R.
26. High Resolution Separation of Proteins Stained with Tricarbocyanine Dyes using Capillary
Zone Electrophoresis with Ultrasensitive Near-IR Fluorescence Detection, B.L. Legendre, Jr.
and S.A. Soper, Appl. Spectrosc. 50 (1996) 1196-1202.
27. An All-Solid State Near-IR Time-Correlated Single Photon Counting Instrument for Dynamic
Lifetime Measurements in DNA Sequencing Applications, B.L. Legendre, Jr., D.C. Williams,
R. Erdmann, U.Ortmann, J. Enderlein, S.A. Soper, Rev. Sci. Instr. 67 (1996) 3984-3989.
28. Near-Infrared, Laser-Induced Fluorescence Detection for DNA Sequencing Applications,
S.A. Soper, B.L. Legendre, D.C. Williams and J. H. Flanagan, IEEE J. Sel. Top. Quant.
Electr. 2 (1996) 1129-1139.
29. Analysis of DNA Restriction Fragments using Capillary Electrophoresis with Near-IR Laser-
Induced Fluorescence Detection, C.V. Owens, Y.Y. Davidson, S. Kar, S.A. Soper Anal.
Chem. 69 (1997) 1256-1261.
30. Ultrasensitive Detection in CE using Near-IR Fluorescence and Diode Laser Excitation, B.L.
Legendre, D. Sately and S.A. Soper, J. Chromatogr. 779 (1997) 185-194.
31. Single-Molecule Detection in the Near-IR Using CW Diode Laser Excitation with an
Avalanche Photon Detector, S.A. Soper and B.L. Legendre, Appl. Spectrosc. 52 (1998) 1-6.
32. Synthesis of Tricarbocyanine Near-IR Fluorescent Dyes for Labeling of Primary Amines,
J.H. Flanagan, S.A. Soper and R.P. Hammer, Bioconj. Chem. 8 (1997) 751-756.
33. Piezoelectric Mechanical Pump with Nanoliter per Minute Pulse-Free Flow Delivery for
Pressure Pumping in Micro-Channels, S. Kar, S. McWhorter, S. Ford and S. A. Soper,
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Soper, Steven A.
Analyst 123 (1998) 1435-1441.
34. Molecular Fluorescence, Phosphorescence and Chemiluminescence Spectrometry, S.A.
Soper, I.M. Warner and L.B. McGowen, Anal. Chem. 70 (1998) 477R-494R.
35. Near-Infrared Heavy-Atom-Modified Fluorescent Dyes for Base-Calling in DNA-Sequencing
Applications using Temporal Discrimination, J. Flanagan, C. Owens, S. Romero, E. Waddell,
S. Khan, R. Hammer and S. A. Soper, Anal. Chem. 70 (1998) 2676-2684.
36. Microcapillary Electrophoresis Devices Fabricated using Polymeric Substrates and X-Ray
Lithography, S. Ford, B. Kar, S. McWhorter, J. Davies, S. A. Soper, M. Klopf, G. Calderon
and V. Saile, J. Microcol. Sep. 10 (1998) 413-422.
37. Sanger DNA Sequencing Reactions Performed in a Solid-Phase Nano-Reactor Directly
Coupled to Capillary Gel Electrophoresis, D.C. Williams, B. Cheng and S.A. Soper, Anal.
Chem. 70 (1998) 4036-4043.
38. A Fiber Optic-based Multichannel Time-Correlated Single Photon Counting Device with Sub-
Nanosecond Time Resolution, E. Waddell, W. Stryjewski, S. A. Soper, Rev. Sci. Instr. 70
(1998) 32-37.
39. High-Aspect Ratio Micromachining in Polymethylmethacrylate (PMMA) using X-Ray
Lithography for the Fabrication of Micro-Electrophoresis Devices, S.M. Ford, J. Davies, B.
Kar, C.V. Owens, S.A. Soper, M. Klopf, G. Calderon and V. Saile, J. Biomech. Eng. 121
(1999) 13-21.
40. A Scanning Near-Infrared Time-Correlated Single Photon Counting Instrument with a Pulsed
Diode Laser and Avalanche Photodiode, Y. Zhang, S. A. Soper, L. Middendorf, J. Wurm, R.
Erdmann, M. Wahl, Appl. Spectrosc. 53 (1999) 497-504.
41. Nanoliter-Scale Sample Preparation Methods Directly Coupled to PMMA-Based Micro-Chips
and Gel-Filled Capillaries for the Analysis of Oligonucleotides. S. A. Soper, S. M. Ford, Y.
Xu, S. Qi, S. McWhorter, S. Lassiter and D. Patterson, J. Chromatogr. A 853 (1999) 107-
120.
42. Pseudosymmetry with Z'=4 in 1,3-propanesultone at 100K. D.R. Billodeaux, C.V. Owens,
C.M. Sayes, S.A. Soper and F.R. Fronczek, Acta Crystallographica 55 (1999) 2126-2129.
43. Conductivity Detection of PCR Products Separated by Open Tubular Liquid
Chromatography. S. McWhorter, S. A. Soper, J. Chromatogr. 883 (2000) 1-9. This article
was featured in Analytical Chemistry, vol. 72, 2000.
44. Time-Resolved Near-IR Fluorescence Detection in Capillary Electrophoresis. E. Waddell, S.
Lassiter and S.A. Soper, J. Liq. Chrom. & Rel. Technol. 23 (2000) 1139-1158.
45. Micro-Capillary Reactors for Direct Sample Introduction into Slab Gels for Solid-Phase DNA
Sequencing. Y. Xu and S.A. Soper, BioTechniques 28 (2000) 904-912.
46. Near-Infrared Fluorescence Detection in Capillary Electrophoresis. S. McWhorter and S.A.
Soper, Electrophoresis 21 (2000) 1267-1280.
47. Microelectromechnical Systems (MEMS) Fabricated in Polymeric Materials: Applications in
Chemistry and Life Sciences. S.A. Soper, S.M. Ford, S. Qi, R.L. McCarley, K. Kelly and
M.C. Murphy, Anal. Chem. 72 (2000) 642A-651A. This article was featured on the cover of
Analytical Chemistry, vol. 72, 2000.
48. Surface Modification of Plastics Used in the Fabrication of Microanalytical Devices, A.C.
Henry, T.T. Tutt, C.S. McWhorter, Y.Y. Davidson, M. Galloway, S.A. Soper, R.L. McCarley,
Anal. Chem. 72 (2000) 5331-5337. This article has been cited over 155 times (02/10).
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