Table Of ContentADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
JOHN D. LAMBRIS, University of Pennsylvania
RODOLFO PAOLETTI, University of Milan
For further volumes:
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Bali Pulendran Peter D. Katsikis
•
Stephen P. Schoenberger
Editors
Crossroads Between Innate
and Adaptive Immunity III
Editors
Bali Pulendran, Ph.D. Stephen P. Schoenberger, Ph.D.
Emory University La Jolla Institute for Allergy
Emory Vaccine Center and Yerkes and Immunology
National Primate Research Center Laboratory of Cellular Immunology
954 Gatewood Road 9420 Athena Circle
Atlanta, GA 30329 La Jolla, CA 92037
USA USA
[email protected] [email protected]
Peter D. Katsikis, M.D., Ph.D.
Drexel University College of Medicine
Department of Microbiology
and Immunology
2900 Queen Lane
Philadelphia, PA 19129
USA
[email protected]
ISSN 0065-2598
ISBN 978-1-4419-5631-6 e-ISBN 978-1-4419-5632-3
DOI 10.1007/978-1-4419-5632-3
Springer New York Dordrecht Heidelberg London
© Springer Science+Business Media, LLC 2011
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Preface
This volume presents a collection of reviews derived from work presented at the
Aegean Conference, “3rd Crossroads between Innate and Adaptive Immunity,” which
occured from September 27 to October 2, 2009 at the Minoa Palace Conference
Center in Chania, Crete, Greece. This meeting was the third in a series, and assembled
a team of scientists working on mechanisms by which the innate immune system of
the host senses pathogens, the cellular and signaling networks that orchestrate the
innate response and antigen presentation and adaptive immunity. The various facets
of the innate response, including dendritic cells, T cells, B cells, NK cells, NK-T cells
and the complement cascade during the host response to pathogens and tumors is
only now starting to be elucidated. The respective fields that focus on these immune
cells and molecules have tended to be relatively compartmentalized, and yet emerging
evidence points to the interconnectedness of these facets in coordinating the innate
response, and its subsequent impact on the adaptive response. The goal of this confer-
ence was to initiate cross-talk between these diverse immunological fields, and
promote and facilitate discussion on the interactions between the innate immune
response and the adaptive immune response and ultimately facilitate collaboration
between these areas of study. Following on the footsteps of the outstanding success
of its precursors, the “3rd Crossroads between Innate and Adaptive Immunity”
Aegean Conference was highly successful in bringing together and connecting
scientists and experts from around the world to address critical areas of Innate and
Adaptive Immunity.
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Acknowledgements
We are grateful to all the participants of this conference whose enthusiasm and willing-
ness to share new data and discuss new ideas truly represent the lifeblood of the
“Crossroads” experience. Those who have contributed chapters to this book deserve
an extra measure of our gratitude, as we are keenly aware of the dedication they
have shown to this field through their extraordinary efforts in this regard. We are
indebted to our colleagues at Springer for giving us the support and opportunity to
publish these proceedings in their Advances in Experimental Medicine and Biology
Book Series, with special thanks to Samantha Lewis for her great help in assembling
and formatting the chapters. As always, we are deeply indebted to the Aegean Con-
ference Organization for the outstanding job they do in making this possible, and
particularly to Dimitrios Lambris for his superb organizational, logistical and inter-
personal skills, that make this meeting such an effortless pleasure for the three of us.
Finally, we wish to express our most sincere gratitude to the various organizations
that made this meeting possible, through their very generous support, including the
Aegean Conferences, Centocor, Drexel University, Springer, Pfizer, and Kirin.
We look forward to seeing all of you in 2011!
Peter D. Katsikis M.D., Ph.D.
Bali Pulendran, Ph.D.
Stephen P. Schoenberger, Ph.D.
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Contents
1 Is Transcription the Dominant Force During Dynamic
Changes in Gene Expression? ............................................................... 1
Martin Turner
2 MicroRNAs: Key Components of Immune Regulation ...................... 15
Donald T. Gracias and Peter D. Katsikis
3 KIR/HLA: Genetic Clues for a Role of NK Cells
in the Control of HIV ............................................................................. 27
Lena Fadda and Galit Alter
4 Natural Killer Cell Licensing During Viral Infection ......................... 37
Mark T. Orr and Lewis L. Lanier
5 Bridging Innate NK Cell Functions
with Adaptive Immunity ....................................................................... 45
Emanuela Marcenaro, Simona Carlomagno,
Silvia Pesce, Alessandro Moretta, and Simona Sivori
6 Control of Innate Immunity by Memory CD4 T Cells ....................... 57
Tara M. Strutt, K. Kai McKinstry, and Susan L. Swain
7 Strategies and Implications for Prime-Boost Vaccination
to Generate Memory CD8 T Cells ........................................................ 69
Jeffrey C. Nolz and John T. Harty
8 Blimp1: Driving Terminal Differentiation to a T ................................ 85
Annie Xin, Stephen L. Nutt, Gabrielle T. Belz, and Axel Kallies
9 A New Role for Myeloid HO-1 in the Innate
to Adaptive Crosstalk and Immune Homeostasis ............................... 101
Vasiliki Koliaraki and George Kollias
10 Impact of Differential Glycosylation on IgG Activity ......................... 113
Anja Lux and Falk Nimmerjahn
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x Contents
11 Murine Model of Chronic Respiratory Inflammation ........................ 125
Amit A. Lugade, Paul N. Bogner, and Yasmin Thanavala
12 Incorporation of Innate Immune Effector Mechanisms
in the Formulation of a Vaccine Against HIV-1 .................................. 143
Aftab A. Ansari, Ann E. Mayne, Yoshiaki Takahashi,
and Kovit Pattanapanyasat
13 Influenza Vaccines: What Do We Want
and How Can We Get It? ...................................................................... 161
Felix Geeraedts and Anke Huckriede
