Chronic Inflammation: Mechanisms and Regulation

679 Pages·2016·19.54 MB·English

by  Masayuki Miyasaka

Masayuki Miyasaka · Kiyoshi Takatsu
Editors
Chronic
Infl ammation
Mechanisms and Regulation
Chronic Inflammation
Masayuki Miyasaka • Kiyoshi Takatsu
Editors
Chronic Inflammation
Mechanisms and Regulation
Editors
MasayukiMiyasaka KiyoshiTakatsu
InterdisciplinaryProgramforBiomedical DepartmentofImmunobiologyand
Sciences PharmacologicalGenetics
InstituteforAcademicInitiatives GraduateSchoolofMedicineand
OsakaUniversity PharmaceuticalSciences
Suita,Japan UniversityofToyama
Toyama,Japan
WPIImmunologyFrontierCenter
OsakaUniversity ToyamaPrefecturalInstituteforPharmaceutical
Suita,Japan Research
Toyama,Japan
MediCityResearchLaboratory
UniversityofTurku
Turku,Finland
ISBN978-4-431-56066-1 ISBN978-4-431-56068-5 (eBook)
DOI10.1007/978-4-431-56068-5
LibraryofCongressControlNumber:2016945256
©SpringerJapan2016
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Preface
Inflammation, a reaction characterized by redness, fever, swelling, and pain, has
been considered a homeostatic tissue repair mechanism, which is evoked by the
body in response to infections and/or tissue injury. However, accumulating evi-
dence indicates that, when inflammation becomes chronic, it acts as a strong
disease-promoting factor in a number of pathological disorders including arterio-
sclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation also pro-
motes aging. Despite such importance, the dismaying fact is that we know very
little about why inflammatory reactions that would usually subside continue and
becomechronic.Morespecifically,wedonotknowpreciselywhattypeoffactors
induce chronic inflammation and promote its prolongation. Also we have little
knowledge about how chronic inflammation causes tissue degeneration and other
disorders.Furthermore, we have no effective treatmentagainst chronic inflamma-
tionatpresent.
Realizingthesesituations,akeyfundingbodyoftheGovernmentofJapan,the
Japan Science and Technology Agency (JST), launched two major research pro-
grams (CREST and PRESTO) on chronic inflammation in 2010; CRESTO is a
fundingprogramforteam-oriented research, whereasPRESTO isforindependent
research by young investigators. From 2010 until now, in the research area of
chronicinflammation,17teamswereselectedforCRESTOandconductedresearch
for5years(eachteamreceiving150–500millionyenintotal),and37researchers
were selected and conducted research for 3–5 years in PRESTO (each scientist
receiving30–40millionyenfor3-yearresearchand50–100millionyenfor5-year
research).
This book represents a compendium of such research efforts. Members of the
CREST and PRESTO projects contributed a chapter on their own work, and
research supervisors of the CRESTO and PRESTO projects (M.M. and K.T.,
respectively) edited the book. As you see in this book, thanks to the painstaking
and persistent hard work by the CRESTO and PRESTO members, we are now
beginning to understand what induces and maintains the chronicity of inflamma-
tion,andwhatkindsofmechanismschronicinflammationutilizestoinducespecific
v
vi Preface
diseasesincludingcancer,degenerativeneurologicaldisorders,andarteriosclerotic
diseases.Wehavealsosucceededincreatingnoveltechnologiesthatallowforthe
earlydetectionandquantitativeassessmentofchronicinflammation.
Producingthisbookrequiredtheeffortsofmanypeoplewhodeservecreditand
thanks.First,wewouldliketothankalltheCRESTO andPRESTO investigators,
whoworkedstrenuouslyonthesubjectofchronicinflammationandcontributeda
nicechapterforthebook.Second,ourspecialthanksgotoresearchofficersofJST
and AMED (Japan Agency for Medical Research and Development) (CREST
“Chronic Inflammation” is now under the supervision of AMED since 2015),
particularly to Shinichi Kato (JST-CREST), Akihiko Kasahara (AMED-CREST),
and Isao Serizawa (PRESTO), who kept the projects organized and meticulously
preparedanumberofresearchmeetingsforthemembers.Third,weareindebtedto
the editorial assistance by Yuko Matsumoto and Yasutaka Okazaki of Springer
Japan.Fourth,wewishtoacknowledgetheconstantsupportandunderstandingof
ourwives,ChiekoTakatsuandEtsukoMiyasaka.Finally,wethankyou,thereader,
foryourinterestinthisresearchfield.Wewillbemorethanhappyifoureffortsare
successfulinprovidingyouwithusefulandstimulatinginformationthatwillleadto
newdevelopmentsinthefieldofchronicinflammation.
Suita,Japan MasayukiMiyasaka
Toyama,Japan KiyoshiTakatsu
September2015
Contents
PartI BasicMechanismsUnderlyingInduction,Progression,and
ResolutionofChronicInflammation
1 ProstaglandinsinChronicInflammation. . . . . . . . . . . . . . . . . . . . 3
TomohiroAokiandShuhNarumiya
2 CellularandMolecularMechanismsofChronicInflammation-
AssociatedOrganFibrosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
TatsuyaTsukui,ShigeyukiShichino,TakeshiShimaoka,SatoshiUeha,
andKoujiMatsushima
3 Sema4AandChronicInflammation. . . . . . . . . . . . . . . . . . . . . . . . 37
DaisukeItoandAtsushiKumanogoh
4 MicroRNAsinChronicInflammation. . . . . . . . . . . . . . . . . . . . . . . 49
Y.Ito,S.Mokuda,K.Miyata,T.Matsushima,andH.Asahara
5 GeneticDissectionofAutoinflammatorySyndrome. . . . . . . . . . . . 63
KojiYasutomo
6 StructuralBiologyofChronicInflammation-AssociatedSignalling
Pathways:TowardStructure-GuidedDrugDevelopment. . . . . . . . 77
ReiyaTaniguchiandOsamuNureki
7 LipidSignalsintheResolutionofInflammation. . . . . . . . . . . . . . . 89
MakotoArita
8 RegulationofChronicInflammationbyControlofMacrophage
ActivationandPolarization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
JunkoSasakiandTakehikoSasaki
9 ClarificationoftheMolecularMechanismsThatNegatively
RegulateInflammatoryResponses. . . . . . . . . . . . . . . . . . . . . . . . . 109
TakashiTanaka
vii
viii Contents
10 TheDrosophilaTollPathway:AModelofInnateImmuneSignalling
ActivatedbyEndogenousLigands. . . . . . . . . . . . . . . . . . . . . . . . . 119
TakayukiKuraishi,HirotakaKanoh,YoshikiMomiuchi,Hiroyuki
Kenmoku,andShoichiroKurata
PartII ImagingAnalysesofChronicInflammation
11 MacrophageDynamicsDuringBoneResorptionandChronic
Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
JunichiKikuta,KeizoNishikawa,andMasaruIshii
12 VisualizationofLocalizedCellularSignallingMediatorsinTissues
byImagingMassSpectrometry. . . . . . . . . . . . . . . . . . . . . . . . . . . 147
YukiSugiura,KuraraHonda,andMakotoSuematsu
13 TrackingofFollicularTCellDynamicsDuringImmuneResponses
andInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 161
TakaharuOkada
PartIII ChronicInflammationandCancer
14 TheRoleofChronicInflammationinthePromotionofGastric
Tumourigenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
HirokoOshima,KanaeEchizen,YusukeMaeda,andMasanobuOshima
15 CellularSenescenceasaNovelMechanismofChronicInflammation
andCancerProgression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
NaokoOhtani
16 EstablishmentofDiagnosisforEarlyMetastasis. . . . . . . . . . . . . . . 201
SachieHiratsuka
17 Non-autonomousTumorProgressionbyOncogenic
Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
ShizueOhsawaandTatsushiIgaki
18 Inflammation-AssociatedCarcinogenesisMediatedbythe
ImpairmentofmicroRNAFunctionintheGastroenterological
Organs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
MotoyukiOtsuka
19 RolesofEpstein–BarrVirusMicroRNAsinEpstein–Barr
Virus-AssociatedMalignancies. . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
AiKotani
PartIV ChronicInflammationandObesity/EnvironmentalStress
20 ChronicityofImmuneAbnormalityinAtopicDermatitis:
InteractingSurfaceBetweenEnvironmentandImmuneSystem. . . 249
TakanoriHidaka,EriH.Kobayashi,andMasayukiYamamoto
Contents ix
21 RoleofDouble-StrandedRNAPathwaysinImmunometabolism
inObesity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
TakahisaNakamura
22 MolecularMechanismsUnderlyingObesity-InducedChronic
Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291
TakayoshiSuganami,MiyakoTanaka,andYoshihiroOgawa
23 RolesofMitochondrialSensingandStressResponseinthe
RegulationofInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 299
KohsukeTakeda,DaichiSadatomi,andSusumuTanimura
24 OxidativeStressRegulationbyReactiveCysteinePersulfides
inInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309
TomohiroSawa
PartV ChronicInflammationandInnateImmunity
25 PosttranscriptionalRegulationofCytokinemRNAControlsthe
InitiationandResolutionofInflammation. . . . . . . . . . . . . . . . . . . 319
OsamuTakeuchi
26 RolesofC-TypeLectinReceptorsinInflammatoryResponses. . . . 333
ShinobuSaijo
27 ElucidationandControloftheMechanismsUnderlyingChronic
InflammationMediatedbyInvariantNaturalKillerTCells. . . . .. 345
HiroshiWatarai
28 UnderstandingoftheRoleofPlasmacytoidDendriticCellsinthe
ControlofInflammationandT-CellImmunity. . . . . . . . . . . . . . . . 357
KatsuakiSato
29 MechanismsofLysosomalExocytosisbyImmuneCells. . . . . . . . . 369
Ji-hoonSongandRikinariHanayama
30 PotentialTherapeuticNaturalProductsfortheTreatmentof
Obesity-AssociatedChronicInflammationbyTargetingTLRsand
Inflammasomes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 379
YoshinoriNagai,HiroeHonda,YasuharuWatanabe,
andKiyoshiTakatsu
PartVI ChronicInflammationandAdaptiveImmunity
31 HumanandMouseMemory-TypePathogenicTh2(Tpath2)Cellsin
AirwayInflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
YusukeEndo,KiyoshiHirahara,KentaShinoda,TomohisaIinuma,
HeizaburoYamamoto,ShinichiroMotohashi,YoshitakaOkamoto,
andToshinoriNakayama
x Contents
32 ControllingtheMechanismUnderlyingChronicInflammation
ThroughtheEpigeneticModulationofCD4TCellSenescence. . . 417
MasakatsuYamashita,MakotoKuwahara,JunpeiSuzuki,
andTakeshiYamada
33 AdrenergicControlofLymphocyteDynamicsandInflammation. . . 429
KazuhiroSuzuki
34 TheMultifacetedRoleofPD-1inHealthandDisease. . . . . . . . . . . 441
MohamedElSherifGadelhaqBadr,KikumiHata,MasaeFuruhata,
HirokoToyota,andTadashiYokosuka
35 TheRoleofLysophospholipidsinImmuneCellTraffickingand
Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 459
MasayukiMiyasaka,AkiraTakeda,ErinaHata,NaokoSasaki,
EijiUmemoto,andSirpaJalkanen
PartVII ChronicInflammationandAutoimmuneDiseases
36 DevisingNovelMethodstoControlChronicInflammationVia
RegulatoryTCells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 475
JamesB.Wing,AtsushiTanaka,andShimonSakaguchi
37 ControlofChronicInflammationThroughElucidationof
Organ-SpecificAutoimmuneDiseaseMechanisms. . . . . . . . . . . . . 489
MitsuruMatsumoto
38 LysophosphatidylserineasanInflammatoryMediator. . . . . . . . . . 501
KumikoMakide,AsukaInoue,andJunkenAoki
39 AberrantActivationofRIG-I–LikeReceptorsandAutoimmune
Diseases. . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .. . . . . 511
HirokiKatoandTakashiFujita
40 ElucidationoftheExacerbationMechanismofAutoimmune
DiseasesCausedbyDisruptionoftheIonHomeostasis. . . . . . . . . . 525
MasatsuguOh-hora
PartVIII ChronicInflammationandAgeing
41 PathophysiologicalRoleofChronicInflammationinAgeing-
AssociatedDiseases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 541
YuichiIkeda,HiroshiAkazawa,andIsseiKomuro
42 UterineCellularSenescenceintheMouseModelofPreterm
Birth. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 555
YasushiHirota