Table Of ContentCHILDHOOD LEUKEMIA:
PRESENT PROBLEMS AND FUTURE PROSPECTS
The Second International Symposium
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33. L. Baker, F. Valeriote and V. Ratanatharathom, cds.: Biology and Therapy of Acute Leukemia.
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34. J. Russo, cd.: Immunocytochemistry in Tumor Diagnosis. 0-89838-737-X.
35. R.L. Ceriani, cd.: Monoclonal Antibodies and Breast Cancer. 0-89838-739-6.
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39. J.G. McVie, et al, cds.: Clinical and Experimental Pathology of Lung Cancer. 0-89838-764-7.
40. K.V. Honn, W.E. Powers and B.F. Sloane, cds.: Mechanisms of Cancer Metastasis. 0-89838-765-5.
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42. A.J. Mastromarino, cd.: Biology and Treatment of Colorectal Cancer Metastasis. 0-89838-786-8.
43. M.A. Rich, J.C. Hager and J. Taylor-Papadimitriou, cds.: Breast Cancer: Origins, Detection and
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44. D.G. Poplack, L. Massimo and P. Comag!ia-Ferraris, cds.: The Role of Pharmacology in Pediatric
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45. A. Hagenbeek and B. LOwenberg, cds.: Minimal Residual Disease in Acute Leukemia 1986.
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46. F.M. Muggia and M. Rozencweig, cds.: Clinical Evaluations of Anti-Tumor Therapy. 0-89838-803-1.
47. F.A. Valeriote and L. Baker, cds.: Biochemical Modulation of Anticancer Agents: Experimental and
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48. B.A. Stoll, cd.: Pointers to Cancer Prognosis. 0-89838-841-4.
49. K.H. Hollmann and J.M. Verley, cds.: New Frontiers in Mammary Pathology 1986. 0-89838-852-X.
50. D.J. Ruiter, G.J. Fleuren and S.O. Wamaar, cds.: Application of Monoclonal Antibodies in Tumor
Pathology. 0-89838-853-8.
51. A.H.G. Paterson and A.W. Lees, cds.: Fundamental Problems in Breast Cancer. 0-89838-863-5.
52. M. Chatel, F. Darcel and J. Pecker, cds.: Brain Oncology. 0-89838-954-2.
53. M.P. Hacker, J.S. Lazo and T.R. Tritton, cds.: Organ Directcd Toxicities of Anticancer Drugs.
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55. J.R. Ryan and L.O. Baker, cds.: Recent Concepts in Sarcoma Treatment. 0-89838-376-5.
56. M.A. Rich, J.C. Hager and D.M. Lopez, cds.: Breast Cancer: Scientific and Clinical Progress.
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57. B.A. Stoll, cd.: Women at High Risk to Breast Cancer. 0-89838-416-8.
58. M.A. Rich, J.C. Hager and I. Keydar, cds.: Breast Cancer: Progress in Biology, Clinical Management
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59. P.I. Reed, M. Carboni, B.J. Johnston and S. Guadagni, cds.: New Trends in Gastric Cancer:
Background and Videosurgery. 0-7923-8917-4.
60. H.K. Awwad: Radiation Oncology: Radiobiological and Physiological Perspectives. 0-7923-0783-6.
61. N. Kobayashi, T. Akera and S. Mizutani: Childhood Leukemia: Present Problems and
Future Prospects. 0-7923-1138-8.
CHILDHOOD LEUKEMIA:
PRESENT PROBLEMS AND FUTURE PROSPECTS
ProceediDp of tbe
SecoDd InternatioDai Sympolium OD CbUdreD'. Cancer
Tokyo, Japu, December 7-9, lfJ8fJ
In Commemoration 01 tlle
20th Anniversary 01
Children 's Cancer Association
01 Japan
edited by
Noboru Kobayubi
Tai Aken
Shuld MimtaDi
~.
"
Springer Science+Business Media, LLC
Ubnry of Congress Cataloglng-in·Pablicadon Data
International Symposium on Children's Cancer (2nd : 1989 : Tokyo,
Japan)
Childhood leukemia : present problems and future prospects :
proceedings of the Second International Symposium on Children's
Cancer, Tokyo, Japan, December 7-9, 1989: edited by Noboru
Kobayashi, Tai Akera, Shuki Mizutani.
p. cm. - (Developments in oncology ; DION 65)
"In Commemoration of the 20th Anniversary of Children's Cancer
Association of Japan."
ISBN 978-1-4613-6739-0 ISBN 978-1-4615-3898-1 (eBook)
DOI 10.1007/978-1-4615-3898-1
1. Leukemia in children-Congresses. 1. Kobayashi, Noboru, 1927-
II. Akera, Tai. III. Mizutani, Shuki. IV. Children's Cancer
Association of Japan. V. Title. VI. Series: Developments in
oncology ; 65.
[DNLM: 1. Leukemia-in infancy & childhood-congresses. Wl
DE998N v. 65 / / WH 250 I6054cj
RJ416.L4I57 1989
618.92'99419-dc20
DNLM/DLC
For Library of Congress 91-6999
CIP
Copyright © 1991 by Springer Science+Business Media New York
Originally published by Kluwer Academic Publishers in 1991
Softcover reprint ofthe hardcover lst edition 1991
Ali rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in
any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written per
mission of the publisher, Springer Science+Business Media, LLC.
Printed on acid-free paper.
CONTENTS
List of Contributors ix
Organizing Committee xiv
Program Committee xv
Preface xvii
Acknowledgments xix
I. Biology of Childhood Leukemia 1
1. Etiological mechanisms in childhood acute lymphoblastic leukemia
Melvyn F. Greaves, Li Chong Chan, Anthony M. Ford, Susan M.
Pegram, and Leanne M. Wiedemann 3
2. The effects of hemopoietic factors on stem cells in vitro
Makio Ogawa, Kenji Kishi, and Jing Ping Shih 23
3. Bone marrow stromal cells and hematopoiesis
Kenichi Harigaya 33
4. Gene transfer investigations of oncogenes activated by chromosomal
translocations in human lymphomas and leukemias: BCL2 and C-MYC
John C. Reed, Michael P. Cuddy, Subrata Haldar, Carlo Croce, Peter
Nowell, David Makover, and Katherine Bradley 43
5. Molecular studies of chromosomal translocations in childhood leukemias
Michael L. Cleary S 1
6. Molecular analysis of chromosomal abnormalities in childhood acute
lymphoblastic leukemia
Yasuhide Hayashi, Susana C. Raimondi and A. Thomas Look S9
7. Immunological properties of hemotopoietic malignancies in chUdhood
Junichiro Fujimoto, Nobutaka Kiyokawa, Hiroo Fujita, Kazumi Imai,
Yoshie Matsubayashi, Yasuo Kokai, and Jun-ichi Hata 69
8. Polymerase chain reaction studies on chronic myelogenous leukemias and
detection of residual PhI clone after bone marrow transplantation
Shuki Mizutani, Kozue Nakamura, Toshiyuki Miyashita, Miwako Ozaki,
Kouichi Miyamura, Takao Matsuei, and Kazuko Tamura 77
vi
9. Lineage-speciflc classification of cblldhood leukemia and its clinical
implications
Keisei Kawa-Ha, Akio Tawa, Keiko Yumara-Yagi, Junichi Hara, and
Shigehiko Ishihara 87
ll. Epidemiology of Childhood Leukemia 9S
10. The epidemiology of leukemia: Results from the Manchester Cblldren's
Tumour Registry
Jillian M. Birch and Valerie Blair 97
11. Contribution of Japan Cblldren's Cancer Registry to medical research and
care of cblldhood leukemia and related conditions
Noboru Kobayashi 107
12. Long-term survivon of leukemia and late effects: A report from the
Registry of Long-Term Survivon of Cblldren's Cancer of Japan
Fumio Bessho 119
m.
Treatment of Childhood Leukemia 127
13. Therapy of cblldhood leukemia: Undentandlng success and failure
Joseph V. Simone, Gaston K. Rivera, A. Thomas Look and William M.
Crist 129
14. Results and significance of six randomized trials in four consecutive ALL
BFM studies
Hansjorg Riehm 135
15. Pharmacokinetics of commonly used anti-leukemic agents in cblldren
W. Archie Bleyer, David G. Poplack, and Frank M. Balis 149
16. Treatment of acute nonlymphoblastic leukemia in the Cblldren's Cancer
and Leukemia Study Group
Masanori Yanai, Yoshiro Tsuji, and Takeo Fujimoto 157
17. Treatment of cblldhood acute lymphoblastic leukemia: The results of the
Tokyo Cblldren's Cancer Study Group L84-11 treatment protocol study
Shinpei Nakazawa et al. 167
vii
18. Bone marrow transplantation in children and adolescents with leukemia
Robert Peter Gale, Anna Butturini, and Mortimer M. Bortin 179
19. Bone marrow transplantation in children and quality of life in long-term
survivors
Shunichi Kato, Miharo Yabe, Hiromasa Yabe, Chidori Kubota, Rumi
Mitsuda, Yasumasa Oh, and Osamu Shinohara 185
20. Autologous bone marrow transplantation for children with leukemia
Mutsuro Ohira and June Takayama 195
21. Peripheral blood stem cell autografts in children with acute leukemia and
lymphoma
Yoichi Takaue and Tsuneo Ninomiya 203
22. Varied problems associated with immunocompromised hosts
Jun-ichi Akatsuka, Takuo Hirotsu, Yasutaka Hoshi, Keiko Kamiya, Yoko
Kato, and Hiroshi Uchiyama 213
IV. The Total Care and the Patient Support System for Children
with Leukemia 223
23. Activities of the Children's Cancer Association of Japan
Keiji Iwata 225
24. Candlelighters: Parents and caregivers, friends and allies, working together
for life
Grace P. Monaco 231
25. Who helps families of children with cancer? Parent and patient support in
the U.K.
Jon Pritchard 239
26. The Ronald McDonald House program in the United States
Audrey E. Evans 247
27. Total care of the child with cancer
Audrey E. Evans, Judith Ross, and Guilio J. D' Angio 251
28. Home care for children with cancer
Ida M. Martinson 259
LIST OF CONTRIBUTORS
Jun-ichi Akatsuka Mortimer M. Bomn
Department of Pediatrics, The Tokyo Medical College of Wisconsin and
Jikei University School of Medicine, 4-11- International Bone Marrow Transplant
1 Izumi-honcho, Komae-shi, Tokyo 201, Registry, P.O. Box 26509, Milwaukee,
Japan Wisconsin 53226, U.S.A
Minom Asada Katherine Bradley
Department of Virology, The National Department of Pathology & Laboratory
Children's Medical Research Center, 3- Medicine, University of Pennsylvania,
35-31 Taishido, Setagaya-ku, Tokyo 154, Philadelphia, Pennsylvania 19104, U.S.A
Japan
Anna Butturini
Frank M. Balis Faculty of Medicine, University of Parma,
Leukemia Biology Section and Pediatric Parma 43700, Italy
Branch, National Cancer Institute,
Bethesda, Maryland 20215, U.SA Li Chong Chan
Leukaemia Research Fund Centre,
Fumio Bessho Institute of Cancer Research, Fulham
Department of Pediatrics, Faculty of Road, London SW3 6JB, U.K.
Medicine, University of Tokyo, 7-3-1
Hongo, Bunkyo-ku, Tokyo 113, Japan William M. Crist
St. Jude Children's Research Hospital,
Jillian M. Birch Memphis, Tennessee 38101, U.SA
CRC Paediatric & Familial Cancer
Research Group, Christie Hospital & Michael L. Cleary
Holt Radium Institute, Manchester M20 Department of Pathology, Stanford
9BX, U.K. University Medical Center, Stanford,
California 94305, U.SA
Valerie Blair
CRC Paediatric & Familial Cancer Carlo Croce
Research Group, Christie Hospital & Fels Institute, Temple University,
Holt Radium Institute, Manchester M20 Philadelphia, Pennsylvania, U.SA
9BX, U.K.
Michael P. Cuddy
W. Archie Bleyer Department of Pathology & Laboratory
Leukemia, Lymphoma, and New Agent Medicine, University of Pennsylvania,
Studies, Childrens Cancer Study Group, Philadelphia, Pennsylvania 19104, U.S.A
University of Washington School of
Medicine, Fred Hutchinson Cancer
Research Center, Children's Hospital and
Medical Center, Seattle, Washington
98195, U.S.A
x
GuiIio J. D'A ngio Subrate Haldar
The Children's Hospital of Philadelphia, Fels Institute, Temple University,
and the Department of Pediatrics and Philadelphia, Pennsylvania, U.S.A
Radiation Oncology, University of
Pennsylvania, Philadelphia, Pennsylvania, Kenichi Harigaya
U.S.A First Department of Pathology, C1nba
University School of Medicine, 1-8-1
Audrey E. Evans Inohana, C1nba City, C1nba 280, Japan
The Children's Hospital of Philadelphia,
and the Department of Pediatrics and Junichi Hara
Radiation Oncology, University of Department of Pediatrics, Osaka
Pennsylvania, Philadelphia, Pennsylvania, University Hospital, 1-1-50 Fukushima-ku,
U.SA Osaka 553, Japan
Anthony M. Ford Jun-ichi Hata
Leukaemia Research Fund Centre, Department of Pathology, The National
Institute of Cancer Research, Fulham Children's Medical Research Center, 3-
Road, London SW3 6JB, U.K. 35-31 Taishido, Setagaya-ku, Tokyo 154,
Japan
Junichiro Fujimoto
Department of Pathology, The National Yasuhide Hayashi
Children's Medical Research Center, 3- St. Jude Children's Research Hospital,
35-31 Taishido, Setagaya-ku, Tokyo 154, Memphis, Tennessee 38101, U.S.A
Japan
Talmo Hirotsu
Takeo Fujimoto The Tokyo Jikei University School of
Department of Pediatrics, Aichi Medical Medicine, Komae-shi, Tokyo, Japan
University, Nagakute-machi, Aichi-gun,
Aichi 480-11, Japan YasutWka lIoshi
The Tokyo Jikei University School of
Hiroo Fujita Medicine, Komae-shi, Tokyo, Japan
Department of Pathology, The National
Children's Medical Research Center, 3- Kazumi Imai
35-31 Taishido, Setagaya-ku, Tokyo 154, Department of Pathology, The National
Japan Children's Medical Research Center, 3-
35-31 Taishido, Setagaya-ku, Tokyo 154,
Robert Peter Gale Japan
Division of Hematology-Oncology, 42-121
CHS, U.C.LA School of Medicine, 10833 Shigehiko Ishihara
Le Conte Av., Los Angeles, California Department of Pediatrics, Osaka
90024-1678, U.S.A University Hospital, 1-1-50 Fukushima-ku,
Osaka 553, Japan
Melvyn F. Greaves
Leukaemia Research Fund Centre, Keiji Iwata
Institute of Cancer Research, Fulham Children's Cancer Association of Japan,
Road, London SW3 6JB, U.K. 1-14-8 Nishi-shinbashi, Minato-ku, Tokyo
105, Japan
xi
Keiko Kamiya Yasuo Kokai
Department of Pediatrics, The Tokyo Department of Pathology, The National
Jikei University School of Medicine, 4-11- Children's Medical Research Center, 3-
1 Izumi-honcho, Komae-shi, Tokyo 201, 35-31 Taishido, Setagaya-ku, Tokyo 154,
Japan Japan
)'akashi Kaneko Chidori Kubota
The Tokyo Municipal Kiyose Children's Department of Pediatrics, Tokai
Hospital, Kiyose, Tokyo, Japan University School of Medicine, Bohseidai,
Isehara, Kanagawa 259-11, Japan
Shunichi Kato
Department of Pediatrics, Tokai A. 1bomas Look
University School of Medicine, Bohseidai, St. Jude Children's Research Hospital,
Isehara, Kanagawa-ken 259-11, Japan Memphis, Tennessee 38101, U.S.A
Yoko Kato David Makover
Department of Pediatrics, The Tokyo Department of Pathology & Laboratory
Jikei University School of Medicine, 4-11- Medicine, University of Pennsylvania,
1 Izumi-honcho, Komae-shi, Tokyo 201, Philadelphia, Pennsylvania 19104, U.S.A
Japan
Ida M. Martinson
Keisel Kawa-Ha Department of Family Health Care
Department of Pediatrics, Osaka Nursing, School of Nursing, University of
University Hospital, 1-1-50 FuJrushima-ku, California San Francisco, San Francisco,
Osaka 553, Japan California, U.S.A
KeoJi Kishi Yoshie Matsubayashi
VA Medical Center and Department of Department of Pathology, The National
Medicine, Medical University of South Children's Medical Research Center, 3-
Carolina, Charleston, South Carolina 35-31 Taishido, Setagaya-ku, Tokyo 154,
29403, U.SA Japan
Nobutaka Kiyokawa Takao Matsuei
Department of Pathology, The National Bone Marrow Transplantation Team,
Children's Medical Research Center, 3- Kanazawa University Medical School, 13-
35-31 Taishido, Setagaya-ku, Tokyo 154, 1 Takara-cho, Kanazawa, Ishikawa 920,
Japan Japan
Naoaki Kobayashi Rumi Mitsuda
Department of Pediatrics, The Tokyo Department of Pediatrics, Tokai
Jikei University School of Medicine, 4-11- University School of Medicine, Bohseidai,
1 Izumi-honcho, Komae-shi, Tokyo 201, Isehara, Kanagawa 259-11, Japan
Japan
Kouichi Miyamura
Noboru Kobayashi Department of Internal Medicine, Nagoya
National Children's Hospital, 3-35-31 University Medical Schoo~ 65 Tsurumai
Taishido, Setagaya-ku, Tokyo 154, Japan cho, Showa-ku, Nagoya 466, Japan
