Challenges in Pediatric Kidney Transplantation: A Practical Guide

429 Pages·2021·7.885 MB·English

by  Katherine E. Twombley

Challenges in
Pediatric Kidney
Transplantation
A Practical Guide
Katherine E. Twombley
Editor
123
Challenges in Pediatric Kidney
Transplantation
Katherine E. Twombley
Editor
Challenges in Pediatric
Kidney Transplantation
A Practical Guide
Editor
Katherine E. Twombley
Department of Pediatrics, Division of Pediatric Nephrology
MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina
Charleston, SC
USA
ISBN 978-3-030-74782-4 ISBN 978-3-030-74783-1 (eBook)
https://doi.org/10.1007/978-3-030-74783-1
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Switzerland AG 2021
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Contents
Part I Immunologic Challenges
1 Immunologic Challenges Pre-transplant . . . . . . . . . . . . . . . . . . . . . . . . 3
Roshan George and Howard M. Gebel
2 Challenges in Post-transplant Immunologic Monitoring . . . . . . . . . . . 25
Rouba Garro and Pamela D. Winterberg
3 Rejection Challenges: Diagnosis and Management . . . . . . . . . . . . . . . . 41
Samantha Lang, Maziar Riazy, and Tom D. Blydt-Hansen
Part II I nfectious Challenges
4 Pretransplant Donor and Recipient Infectious Challenges . . . . . . . . . . 121
Sarah Kizilbash and Jodi M. Smith
5 Post-transplant Recipient Infectious Challenges . . . . . . . . . . . . . . . . . . 145
Isa F. Ashoor and Sonia Solomon
Part III D isease Challenges
6 Urological Considerations for Pediatric Renal
Transplantation: CAKUT Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . 179
Oana Nicoara, Hailey Silverii, and Shumyle Alam
7 Rheumatologic Challenges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193
Sonia I. Savani and Mileka Gilbert
8 Recurrent Disease Challenges in Pediatric Kidney
Transplantation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Lyndsay A. Harshman and Sharon M. Bartosh
9 Nephrotic Syndrome Challenges: An Old Recurring Problem. . . . . . . 245
German Lozano Guzman and Joshua J. Zaritsky
v
vi Contents
10 Challenges of Maintaining Adequate Health and
Well-Being, Growth, Nutrition, and Development in
Pediatric Transplant Recipients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Kristen Sgambat, Kaushalendra Amatya, and Asha Moudgil
Part IV M edication Challenges
11 Challenges Surrounding Induction Protocols in Children . . . . . . . . . . 289
Raphael H. Parrado and Satish N. Nadig
12 Post-transplant Medication Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 305
Nida Siddiqi and Alesa Campbell
Part V S urgical Challenges
13 Challenges in Surgical Approach and Complications in
Pediatric Renal Transplant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Aleah L. Brubaker and Beau Kelly
14 Multiorgan Transplantation Challenges . . . . . . . . . . . . . . . . . . . . . . . . . 371
Rachel M. Engen and Priya Verghese
Part VI Ethical Challenges
15 Ethical Challenges in Pediatric Kidney Transplantation . . . . . . . . . . . 397
James Johnston and Aviva Goldberg
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 423
Contributors
Shumyle Alam, MD Department of Urology, MUSC Shawn Jenkins Children’s
Hospital/Medical University of South Carolina, Charleston, SC, USA
Kaushalendra  Amatya, PhD Children’s National Hospital Washington DC,
Division of Nephrology, Washington, DC, USA
Isa F. Ashoor, MD Department of Pediatrics, LSU Health and Children’s Hospital
New Orleans, New Orleans, LA, USA
Sharon  M.  Bartosh, MD University of Wisconsin, Division of Pediatric
Nephrology, Pediatric Kidney Transplantation, Madison, WI, USA
Tom D. Blydt-Hansen, MDCM, FRCPC Department of Pediatrics, University of
British Columbia, Vancouver, BC, Canada
Aleah L. Brubaker, MD, PhD Division Abdominal Transplantation, Department
of Surgery, Stanford University, Stanford, CA, USA
Alesa Campbell, PharmD Department of Pharmacy, Montefiore Medical Center,
Bronx, NY, USA
Rachel M. Engen, MD, MS Department of Pediatrics, Northwestern University
Feinberg School of Medicine, Chicago, IL, USA
Rouba Garro, MD Pediatric Nephrology, Emory University School of Medicine
Department of Pediatrics, Atlanta, GA, USA
Children’s Health Care of Atlanta, Atlanta, GA, USA
Howard M. Gebel, PhD Histocompatibility & Immunogenetics Labs, Emory
Medical Laboratory, Emory University School of Medicine, Atlanta, GA, USA
Roshan  George, MD, PhD Department of Pediatrics; Division of Pediatric
Nephrology, Emory University and Children’s Healthcare of Atlanta,
Atlanta, GA, USA
Mileka  Gilbert, MD, PhD Department of Pediatrics, Division of Pediatric
Rheumatology, MUSC Shawn Jenkins Children’s Hospital/Medical University of
South Carolina, Charleston, SC, USA
vii
viii Contributors
Aviva Goldberg, MD Department of Pediatrics and Child Health, Max Rady
College of Medicine, University of Manitoba, Winnipeg, MB, Canada
German Lozano Guzman, MD Section of Nephrology St Christopher Hospital,
Philadelphia, PA, USA
Lyndsay A. Harshman, MD University of Iowa Organ Transplant Center, Iowa
City, IA, USA
James Johnston, MD Department of Pediatrics and Child Health, Max Rady
College of Medicine, University of Manitoba, Winnipeg, MB, Canada
Beau Kelly, MD, MBA, FACS DCI Donor Services, West Sacramento, CA, USA
Sarah Kizilbash, MBBS, MS Department of Pediatrics, University of Minnesota,
Minneapolis, MN, USA
Samantha Lang, MBBS, BSc Department of Experimental Medicine, University
of British Columbia, Vancouver, BC, Canada
Asha Moudgil, MD Children’s National Hospital Washington DC, Division of
Nephrology, Washington, DC, USA
Satish  N.  Nadig, MD, PhD Division of Transplant Surgery, Department of
Surgery, Medical University of South Carolina, Charleston, SC, USA
Oana Nicoara, MD Department of Pediatrics, Division of Pediatric Nephrology,
MUSC Shawn Jenkins Children’s Hospital/Medical University of South Carolina,
Charleston, SC, USA
Raphael H. Parrado, MD Department of General Surgery, Medical University of
South Carolina, Charleston, SC, USA
Maziar Riazy, MD, PhD, FRCPC Department of Pathology and Laboratory
Medicine, University of British Columbia, Vancouver, BC, Canada
Sonia I. Savani, MD Department of Medicine and Department of Pediatrics,
Medical University of South Carolina, Charleston, SC, USA
Kristen  Sgambat, PhD, RD Children’s National Hospital Washington DC,
Division of Nephrology, Washington, DC, USA
Nida Siddiqi, PharmD Department of Pharmacy, Sidra Medicine, Doha, Qatar
Hailey Silverii, MD Department of Urology, MUSC Shawn Jenkins Children’s
Hospital/Medical University of South Carolina, Charleston, SC, USA
Jodi M. Smith, MD, MPH Department of Pediatrics, Seattle Children’s Hospital/
University of Washington, Seattle, WA, USA
Sonia Solomon, DO Department of Pediatric Nephrology, Maria Fareri Children’s
Hospital/New York Medical College/Westchester Medical Center/Boston Children’s
Health Physicians, Valhalla, NY, USA
Contributors ix
Priya Verghese, MBBS, MPH Department of Pediatrics, Northwestern University
Feinberg School of Medicine, Chicago, IL, USA
Pamela D. Winterberg, MD Pediatric Nephrology, Emory University School of
Medicine Department of Pediatrics, Atlanta, GA, USA
Children’s Health Care of Atlanta, Atlanta, GA, USA
Joshua  J.  Zaritsky, MD, PhD Division Chief Section of Nephrology St
Christopher Hospital, Philadelphia, PA, USA
Part I
Immunologic Challenges