Table Of ContentBiomedical
Applications of
Nanoparticles
Biomedical
Applications of
Nanoparticles
Edited by
Alexandru Mihai Grumezescu
Faculty of Applied Chemistry and Materials Science,
University Politehnica of Bucharest, Bucharest, Romania
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Contributors
Kainat Alam
Christian College ofNursing,Shalom Instituteof Health and AlliedSciences
(SIHAS),SamHigginbottomUniversityofAgriculture,TechnologyandSciences
(SHUATS), Allahabad,India
Ana C.S. Alcantara
Department ofChemistry, Federal University ofMaranha˜o, Sa˜o Luis,Brazil
Firoz Anwar
Department ofBiochemistry, FacultyofScience, KingAbdulaziz University,
Jeddah,Kingdom ofSaudi Arabia
MakbuleAsikoglu
Department ofRadiopharmacy, Faculty ofPharmacy, Ege University, Izmir,
Turkey
Evren Atlihan Gundogdu
Department ofRadiopharmacy, Faculty ofPharmacy, Ege University, Izmir,
Turkey
K. Balakumar
Department ofPharmaceutics, PSG Collegeof Pharmacy, Coimbatore, India
Sarwar Beg
ProductDevelopment Research, Jubilant Generics Limited, Noida, India
Jigna R. Bhamore
Department ofAppliedChemistry, S.V. NationalInstitute ofTechnology, Surat,
India
CoraliaBleotu
Stefan S Nicolau Institute ofVirology,Bucharest, Romania
R. Chandrasekar
Department ofPharmacognosy, MNR College ofPharmacy, Sangareddy,India
Subhash Chandra Chaturvedi
Sri AurobindoInstituteofPharmacy, Indore,Madhya Pradesh, India
Ying Chau
DepartmentofChemicalandBiologicalEngineering,TheHongKongUniversityof
Science and Technology, Hong Kong SAR, China
Mariana-Carmen Chifiriuc
The ResearchInstituteofthe University ofBucharest (ICUB), University of
Bucharest, Bucharest, Romania
xvii
xviii Contributors
Veronica M. Couto
DepartmentofBiochemistryandTissueBiology,InstituteofBiology,Universityof
Campinas—UNICAMP, Campinas, Brazil
Carmen Curutiu
The Research Institute ofthe University of Bucharest (ICUB), University of
Bucharest, Bucharest,Romania
Eneida de Paula
DepartmentofBiochemistryandTissueBiology,InstituteofBiology,Universityof
Campinas—UNICAMP, Campinas, Brazil
N. Duganath
QualityControl, Time PharmaceuticalsPrivateLimited, Gaindakot,Nepal
MelihaEkinci
Department ofRadiopharmacy,Faculty ofPharmacy, EgeUniversity, Izmir,
Turkey
Denisa AlexandraFlorea
University Politehnicaof Bucharest,Bucharest, Romania
MichelleFranz-Montan
Department ofPhysiological Sciences, Piracicaba Dental School, UNICAMP,
Piracicaba,Brazil
G. Granero
Department ofPharmaceutical Sciences, UNITEFA, CONICET, Faculty of
Chemical Sciences, National University ofCo´rdoba, Co´rdoba, Argentina
Alexandru Mihai Grumezescu
University Politehnicaof Bucharest,Bucharest, Romania
Valentina Grumezescu
National Institute for Lasers, Plasma, and Radiation Physics, Magurele;
Faculty ofApplied Chemistry and Materials Science,PolitehnicaUniversity of
Bucharest, Bucharest,Romania
S.M.HabiburRahman
Department ofPharmaceutics, PSG College ofPharmacy, Coimbatore, India;
DepartmentofPharmaceuticalTechnology,FacultyofPharmaceuticalSciences,
UCSI University, KualaLumpur, Malaysia
R. Hariprasad
DepartmentofPharmaceuticalAnalysis,PSGCollegeofPharmacy,Coimbatore,
India
Derya Ilem-Ozdemir
Department ofRadiopharmacy,Faculty ofPharmacy, EgeUniversity, Izmir,
Turkey
GhodsiehsadatJahanmir
DepartmentofChemicalandBiologicalEngineering,TheHongKongUniversityof
Science and Technology, Hong Kong SAR, China
Contributors xix
Shashank Jain
DepartmentofProductDevelopment,G&WLaboratories,SouthPlainfield,NJ,
United States
Sachin A.Joshi
Dr.K.C.PatelResearchandDevelopmentCentre,CharotarUniversityofScience
and Technology(CHARUSAT), Anand,India
Suresh Kumar Kailasa
Department ofAppliedChemistry, S.V. NationalInstitute ofTechnology, Surat,
India
Pinak Khatri
Department ofProductDevelopment,G&W PA Laboratories, Sellersville,PA,
United States
JanardhanReddyKoduru
DepartmentofEnvironmentalEngineering,KwangwoonUniversity,Seoul,South
Korea
Vikas Kumar
Natural ProductDrug Discovery Laboratory,Department ofPharmaceutical
Sciences, Shalom Instituteof Health and AlliedSciences (SIHAS),Sam
Higginbottom University ofAgriculture, Technology and Sciences (SHUATS),
Allahabad,India
Senshang Lin
College ofPharmacy and Health Sciences, St. John’s University, Queens, NY,
United States
Sandra Pena Luengas
Bio Target, Chicago,IL, United States
Paolo Macor
Life Science,University ofTrieste,Trieste,Italy
Eduardo Mansilla
SchoolofMedicalSciences,NationalUniversityofLaPlata,CONICETLaPlata,La
Plata, Argentina
GustavoH. Marin
SchoolofMedicalSciences,NationalUniversityofLaPlata,CONICETLaPlata,La
Plata; CONICET,Buenos Aires, Argentina
GrigoreMihaescu
The ResearchInstituteofthe University ofBucharest (ICUB), University of
Bucharest, Bucharest, Romania
Irina Negut
FacultyofPhysics, University ofBucharest, Bucharest; NationalInstitute
for Lasers, Plasma, and Radiation Physics, Magurele,Romania
Silvia V.G. Nista
Department ofMaterials Engineering and Bioprocess, Chemical Engineering
Faculty, UNICAMP,Campinas, Brazil
xx Contributors
Luis Nunez
Bio Target,Chicago,IL, United States
R. Onnainty
Department ofPharmaceutical Sciences, UNITEFA, CONICET, Faculty of
Chemical Sciences, National University ofCo´rdoba, Co´rdoba, Argentina
EmreOzgenc
Department ofRadiopharmacy,Faculty ofPharmacy, EgeUniversity, Izmir,
Turkey
TaeJung Park
Department ofChemistry, Instituteof Interdisciplinary ConvergenceResearch,
ResearchInstitute ofHalal Industrialization Technology, Chung-AngUniversity,
Seoul, RepublicofKorea
Niket Kumar Patel
Formulation Development Department, Charles River Laboratories, Boothwyn,
PA, United States
Gayatri C.Patel
Department ofPharmaceutical Technology, RamanbhaiPatel College of
Pharmacy,CharotarUniversityofScienceandTechnology(CHARUSAT),Anand,
India
Laura Ma˘da˘linaPetcu
The Research Institute ofthe University of Bucharest (ICUB), University of
Bucharest; NationalInstituteof Diabetes Nutritionand MetabolicDiseases
(NIDNMD) “Prof. N. C.Paulescu”, Bucharest,Romania
Ariana Aristina Picu
The Research Institute ofthe University of Bucharest (ICUB), University of
Bucharest; NationalInstituteof Diabetes Nutritionand MetabolicDiseases
(NIDNMD) “Prof. N. C.Paulescu”, Bucharest,Romania
Gratiela GradisteanuPircalabioru
The Research Institute ofthe University of Bucharest (ICUB), University of
Bucharest; Sanimed InternationalImpexS.R.L., Bucharest, Romania
Mahfoozur Rahman
Department ofPharmaceutical Sciences, Shalom InstituteofHealth and Allied
Sciences(SIHAS),SamHigginbottomUniversityofAgriculture,Technologyand
Sciences (SHUATS), Allahabad,India
Ligia N.M. Ribeiro
DepartmentofBiochemistryandTissueBiology,InstituteofBiology,Universityof
Campinas—UNICAMP, Campinas, Brazil
Luis Rivera
ChemistryDepartment,MayaguezCampus,UniversityofPuertoRico,SanJuan,
PR, UnitedStates
Contributors xxi
S. Sansare
Department ofPharmaceutical Sciences, University ofConnecticut, Storrs, CT,
United States
MansiK.Shah
Department ofObstetrics &Gynecology, University ofTexas MedicalBranch,
Galveston, TX,UnitedStates
S. Shidhaye
Vivekanand Education Society’sCollegeof Pharmacy, Mumbai, India
R. Singh
CereliaNutritech Pvt Ltd, New Delhi,India
KarthikSiram
Department ofPharmaceutics, PSG Collegeof Pharmacy, Coimbatore, India
Sudha Vengurlekar
Sri AurobindoInstituteofPharmacy, Indore,Madhya Pradesh, India
NamrataVora
Department ofFormulation Development, Xcelience (A division ofCapsugel),
Tampa, FL,United States
Hamna Yasin
Department ofBotany, Lahore College for Women University Lahore, Lahore,
Pakistan
Zubaida Yousaf
Department ofBotany, Lahore College for Women University Lahore, Lahore,
Pakistan
Maria-Elena Zarif
University Politehnica ofBucharest, Bucharest, Romania
Foreword
Clinicalpracticehassignificantlybenefitedbytherecentprogressofinterdisciplin-
aryfieldssuchasbiomaterialsengineeringandnanobiodevices.Importanttoolsand
approaches have emerged to push forward the modern concept of medical care by
supporting the development ofpersonalized medicine concept.
Nanodevicesthatcouldbeusedtospecificallytargetdiseasedsitesandintelligent
systems able to repair damages or replace molecules, cells, and even tissues are
intensively investigated. Numerous diagnosis and therapeutic strategies based on
these advances are currently applied in the biomedical field, some of those posing
an important impact in life support, early disease detection, and efficient therapy
of modern illnesses. However, important aspects regarding their specific function,
long-term medical impact, and social considerations related with the current use
of such therapiesare far of being understood.
Thisbookbringstogethernovelfindingsonthechallengingfieldofnanobioma-
terials, empathizing on the most investigated applications of such nanosized struc-
tures in the medicine and life sciences. The work entitled Biomedical
Applications of Nanomaterials brings relevant news regarding the production
methods and development of tailored drug delivery nanosystems, diagnosis tools
based on nanotechnology, pharmacology of nanosized drugs, and summing up the
mostrecentlyformulatedperspectivesonthefield.Relevantexamplesinthetherapy
of severe and difficult- or no-cure diseases of the modern society are given in this
internationallycoauthoredwork.The17chaptersofthisbookarenicelyillustrated
and contain scientifically sound information, mixing introductive basic aspects of
nanobiomaterialsengineeringwithcutting-edgetechnologicaladvancesthatenable
a more precise biomedical act.
Thebookisagreatscientificresource,editedbyapassionateandinternationally
recognized scientist, which provides novel ideas and examples regarding the bio-
medical applications of nanomaterials.
AlinaMaria Holban
Facultyof Biology, Universityof Bucharest, Bucharest,Romania
xxiii
