Automated Arrhythmia Detection - Safety Pharmacology Society

16 Pages·2011·1.04 MB·English

Arrhythmia Detection: A Quest for
Signal Quality and Computerized Tools
Simon Authier, D.V.M., M.B.A., Ph.D.
Director of Veterinary Science and Safety Pharmacology
LAB Research Inc.
Background
 EMG artifacts interfere with automated detection
 Various ECG leads presented mixed results:
 SC leads → significant EMG artifacts
 IC leads → variable ECG morphology
 Pericardiac leads→ Invasive + lengthy recovery
Junctional Ventricular AV-block II
35 dB
30 dB
25 dB
20 dB
15 dB
10 dB
Intravenous Biopotential Lead
Based on Standard DSI ECG Lead
Standard DSI ECG Lead Coil & Insulation
Added:
Rounded Bullet Tip:
For easy passage through
vessel.
Intravenous Biopotential Lead in a Cynomolgus monkeys
Anatomical placement is critical for stable ECG morphology
ECG from Cynomolgus Monkey with
IV Biopotential Leads
Signal (R-wave) to noise ratio: Comparison of SC leads with IV
Biopotential lead and diaphragmatic
700
IV Biopotential leads
600
Subcutaneous leads
500
400
V
m
~
300
200
100
0
16:01 20:49 1:37 6:25 11:13
Time
Macroscopic examination
 6 animals: 6 months
 No macroscopic
abnormality
Intravenous Biopotential Lead
Histopathology of vena cava of cynomolgus monkeys after 6 months
20x Mild thickening intima/subintima with intimal proliferation. 400x
Comparison with Permanent IV Catheters
Incidences of Catheterization System-Related Microscopic Observations in Cynomolgus
Monkeys after 6 months (AVA Biomedical Cath-in-Cath)
Finding Males (n=3) Females (n=4)
Chronic Active Inflammation 2 1
Minimal 0 0
Mild 0 0
Moderate 1 1
Marked 1 0
Intimal Proliferation 0 3
Minimal - 2
Mild - 1