Apparatus and methods for controlling sonic treatment

41 Pages·2013·4.02 MB·English

US007521023B2
(12) United States Patent (10) Patent N0.: US 7,521,023 B2
Laugharn, Jr. et a]. (45) Date of Patent: Apr. 21, 2009
(54) APPARATUS AND METHODS FOR (56) References Cited
CONTROLLING SONIC TREATMENT
U.S. PATENT DOCUMENTS
(75) Inventors: James A. Laugharn, Jr., Winchester, _
MA (Us); Brevard s_ Garrison’ i * 1150011138 et al. .............. .. 516/38
' i i ran in
Readmg’ MA (Us) 2,565,159 A 8/1951 Williams .................. .. 171/327
(73) Assignee: Covaris, Inc., Woburn, MA (US) 2,578,505 A * 12/1951 Carlin 366/114
( * ) Notice: Subject to any disclaimer, the term of this i hams """"""""" " 366/127
. . i , Pless, Jr. et a1.
Patent 15 extended or adlusted under 35 2,855,526 A 10/1958 Jones ....................... .. 310/85
U-S-C- 154(1)) by 0 days- 2,864,592 A 12/1958 Camp ....................... .. 366/127
(21) APPL No‘: 10/777 014 2,916,265 A * l2/l959 ToWnc ..... .. 366/133
, 2,950,725 A 8/1960 Jackc ct al. . 134/184
' . 3,066,686 A 12/1962 O’Ncill 134/122
(22) Med‘ Feb‘ 11’ 2004 3,194,640 A 7/1965 Nesh .... .. . 23/293
(65) Prior Publication Data (Continued)
US 2004/0264293 A1 Dec. 30, 2004 FOREIGN PATENT DOCUMENTS
Related US. Application Data DE 2557668 6/1977
(63) Continuation of application No. 09/830,473, ?led as (Continued)
appl1cat1on No. PCT/US99/25274 on Oct. 28, 1999,
noW Pat. No. 6,719,449. OTHER PUBLICATIONS
(60) Provisional application No. 60/ 148,279, ?led on Aug. “Early experience With high-intensity focused ultrasound for the
11, 1999, provisional application NO_ 60/143,44(), treatment of benign prostatic hypertrophy”, Sullivan et al, British
?led on Jul. 13, 1999, provisional application No. JOumal“Urology,"0L79,1311 172'176idated1997~*
60/'119,500, ?led on Feb. 10, 1999, prov1s1onal appl1- (Continued)
cat1on No. 60/110,460, ?led on Dec. 1, 1998, prov1
sional application No. 60/ 105,933, ?led on Oct. 28, Primary ExamineriTony G Soohoo
1998. (74) Attorney, Agent, or FirmiWolf, Green?eld & Sacks,
RC.
(51) Int. C1.
3063 1/00 (2006.01) (57) ABSTRACT
B01F 11/02 (2006.01)
(52) us. Cl. ..................................... .. 422/128; 366/127 Apparatus and methods are disclosed for treating a Sample by
(58) Field of Classi?cation Search ............... .. 366/132, Selectively Controlling Sonic energy and/Or Selectively 9911
366/151 _1’ 1522’ 127’ 116; 422/127’ 128’ trolling the location ofthe sample relative to the sonic energy.
422/20
See application ?le for complete search history. 62 Claims, 11 Drawing Sheets
POSITIONING
SYSTEM FOR SUPPORT FOR
_______________ "r400 TARGET MICROT'EE“ PLATE FOCUSED TTRANSSEUCER
USER /‘°° cgiiigiiién TLIQEEHRETAJQE MICROTITER lam/USE SAMPLE
i INPUTIOUTPUT ‘I m CONTROLLER PLQTE SAIgZLE 162K
1 i: CONTROL APOWEIF‘ __|" MEWANISM ACOUSTICALLY ,' I '. \
é. °°MI_;% TERT§" 7 ..... ...... _ ULTRASONIC 88 t -1‘ '=.1 '1,
___________ u A USTIC FIELD I; II
800
W A FLUID BATH L
200____"' (‘95111251521321 —>AMP|.|F|EH 60o PIEZC0§§ETRIC
_2_1Q ' 1
l l
..................................... .. WEE“ TRANSDUCER
500 TANK
US 7,521,023 B2
Page 2
US. PATENT DOCUMENTS 6,042,556 A * 3/2000 Beach etal. ................. .. 601/3
6,086,821 A * 7/2000 Lee ....... .. .422/102
3292910 A 12/1966 Mariner 6,100,084 A 8/2000 Miles et a1. ............ .. 435/306.1
3,396,286 A 8/1968 Anderson et a1- ---------- -- 310/91 6,210,128 B1 4/2001 Rife et a1. ................. .. 417/322
3,481,186 A * 12/1969 Plofsky et a1. . 73/612 6,224,778 131* 5/2001 Peltzer ' 366M521
3,614,069 A 10/1971 Murry ------ -- 366/119 6,244,738 B1 6/2001 Yasudaet a1. ............. .. 366/114
3743523 A * 7/1973 Bodine 366/108 6,277,332 B1 8/2001 Sucholeiki ................ .. 366/127
3,807,704 A 4/1974 JanZen er a1~ 6,284,113 B1 9/2001 Bjornson etal. .......... .. 204/453
3,837,805 A 9/1974 Boucher 6,291,180 B1 9/2001 Chu
3,876,890 A 4/1975 Brown et a1- --------------- -- 310/81 6,361,747 B1 3/2002 Dion et a1. ................ .. 422/128
4,028,933 A 6/1977 Lemons er a1~ 6,413,783 B1 7/2002 Wohlstadteretal. 366/108
4307964 A 12/1981 1119189911 etal- ---------- -- 366/127 6,440,725 B1* 8/2002 Pourahmadi et a1. ...... .. 422/100
RE31J79 E 12/1984 Alllger ----- -- - 6,515,030 B1 2/2003 Bechtel et a1. ............ .. 366/127
4,488,816 A 12/1984 Vota ......................... .. 366/116 6,699,711 B1 3/2004 Hahn et 31‘
4,541,281 A 9/1985 Chubachietalr 6,719,449 B1 4/2004 Laugharn, Jr. etal.
4,571,087 A 2/1986 Ranney .................... .. 366/108 6,737,021 B2 5/2004 Watarietal‘
4,644,808 A 2/1987 Lecoffre 2004/0076545 A1 4/2004 Watarietal.
4,764,905 A * 8/1988 GranZ et a1. .............. .. 310/335 Zoos/0150830 A1 7/2005 Laugham et 31‘
4,834,124 A 5/1989 Honda ......................... .. 134/1
4,862,060 A 8/ 1989 Scott et a1. FOREIGN PATENT DOCUMENTS
4,879,011 A * 11/1989 Schram ............... .. 204/157.42
4,889,122 A * 12/1989 Watrnough et a1. ..... .. 601/3 DE 19534955 “996
4,926,871 A * 5/1990 Gangulyetal. 600/443 DE 19617924 “£1997
4,983,189 A * 1/1991 Peterson etal. 366/127 DE 19756874 A1 61999
5,026,167 A 6/1991 Berliner, III .. 366/150 DE 19820466 “£1999
5,037,481 A 8/1991 Bran ........... .. 134/1 5;: 1823333; 5333;‘
5,395,592 A * 3/1995 Bolleman etal. . .310/309 “995
5,484,573 A 1/1996 Berger etal. .... .. .. 422/128 E? (322222; A1 30003
5,523,058 A 6/1996 Umemura et a1. ......... .. 366/127
5,623,095 A 4/1997 Beller GB 1105962 10966
5,631,425 A * 5/1997 Wang etal. ..... .. 73/606 82) woggl/ggig A332
5,639,423 A 6/1997 Northrup etal. 122/50
5,681,396 A * 10/1997 Madanshetty . 134/1.3 OTHER PUBLICATIONS
5,688,406 A 11/1997 Dickinson et a1. . 366/127
5,736,100 A 4/199g Miyake et a1, __ 366/127 “A prototype ofa 5001<HZ ultrasonic Matricial Device: Beam Scan
5,759,162 A * 6/199g ()ppelt et a1, __ 601/2 ner, Application to in-vivo heel bone quantitative characterization”,
5,779,985 A 7/1998 Sucholeiki ................ .. 422/128 Defontaineetal,l999IEEEU1tras9ni9Ssymposiumrpn1585-1588,
5,803,099 A 9/1998 Sakuta et a1. datedl999~*
5,831,166 A * 11/1998 Kozuka et a1‘ ______________ __ 73/570 “SomeapplicationsofUltrasonics”, Brockelsby, J. Sci.Instrum.,vol.
5,834,648 A * 11/1998 Wang etal. ................. .. 73/606 ‘lo/PP153-156,dated1963~* _ _
5,890,802 A 4/l999 Evensen et a1‘ _ 366/127 “A new method for the generatlon and use of focused ultrasound 1n
5,993,671 A * “H999 Peltzer 210/739 experimentalbiology”, as submittedon Jul. 6, 1942, Lynnetal.,The
6,003,388 A * 12/1999 Oe?ering ' 73/864 01 Journal of General Physiology, vol.*26, The Rockefeller University
6,010,316 A 1/2000 Haller et a1. .............. .. 417/322 press’pp' l79'l93’copynght 1942'
6,039,309 A * 3/2000 Kuklinski .................... .. 261/1 * cited by examiner
US. Patent Apr. 21, 2009 Sheet 1 or 11 US 7,521,023 B2
M5_-........-...9....9..0. ....... ... 5.i......u... :%502n ;
[email protected]. n2w5m, wm l
o8“w9z“o2 mm0Eoua2mo5> w3<> >
0"2ME5D. Z1E6Q5 E2E0 0
"0152dm >9 .525
a""w"z_zoEmon_
m@"mu@o5w5z0w5w:
E0058; an"m0n 20o.2 5w % mwQEm.Awob8EIqs mM]Ew Tz “w,o
"_Eo-8\-. awma.zIw _ww..... .....m.... l
Z1orr“o"u:259 2250.6%m2 2
Hm_ma w |||11|1||||||I|n||||||a||I1|I||l||||||||||||_ | ._ ‘lm1Jm=m5g2m:m mm.05 m5 m55 o50 0 2 00 1||_|"||r|| L|||0|| aa||||||||||1I|l||:|||1||1||||||II 0 w
\mS?5m3an0 5m2m8 wz mz
8_._m
.F8OwE
_"

US. Patent Apr. 21, 2009 Sheet 4 or 11 US 7,521,023 B2
80@mS%\
F
:lDl
@S/
.mUmE .OUmE
Sm
mom
US. Patent Apr. 21, 2009 Sheet 5 0f 11 US 7,521,023 B2
mm
,/1V/m .NOE
lull-I
Jl
llll
US. Patent Apr. 21, 2009 Sheet 6 0f 11 US 7,521,023 B2
>I5.0.5..
__
ON 06 Qm o6 Qm 0N
wmnEmwaEE
6$.5;
.mOE
US. Patent Apr. 21, 2009 Sheet 7 0f 11 US 7,521,023 B2
mOm mmO
.EOnED
j
x242.
@N
/
Ey
EMEES
L ww
_
/
Q O
2m><0>>
L I ' ,
__>>_,oQz
.,m,_m _
oFnwDO O<O ED M200
mmmtkowmmOzDzO Om :EM2F;
ow
%
/wh im W/