Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Nutraceuticals and Functional

245 Pages·2017·25.7 MB·English

Oxidative Medicine and Cellular Longevity
Antioxidant, Anti-Inflammatory, and
Microbial-Modulating Activities of
Nutraceuticals and Functional Foods
Lead Guest Editor: Ilaria Peluso
Guest Editors: Thea Magrone, Débora Villaño Valencia, Chung-Yen Oliver Chen,
and Maura Palmery
Antioxidant, Anti-Inflammatory,
and Microbial-Modulating Activities
of Nutraceuticals and Functional Foods
Oxidative Medicine and Cellular Longevity
Antioxidant, Anti-Inflammatory,
and Microbial-Modulating Activities
of Nutraceuticals and Functional Foods
Lead Guest Editor: Ilaria Peluso
Guest Editors: Thea Magrone, Débora Villaño Valencia,
Chung-Yen Oliver Chen, and Maura Palmery
Copyright©2017Hindawi.Allrightsreserved.
Thisisaspecialissuepublishedin“OxidativeMedicineandCellularLongevity.”Allarticlesareopenaccessarticlesdistributedunderthe
CreativeCommonsAttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedthe
originalworkisproperlycited.
Editorial Board
AntonioAyala,Spain HusamGhanim,USA PálPacher,USA
PeterBackx,Canada DanielaGiustarini,Italy ValentinaPallottini,Italy
DamianBailey,UK SaeidGolbidi,Canada SerafinaPerrone,Italy
ConsueloBorrás,Spain TilmanGrune,Germany TizianaPersichini,Italy
VittorioCalabrese,Italy TimHofer,Norway VincentPialoux,France
AngelCatalá,Argentina SilvanaHrelia,Italy AdaPopolo,Italy
Shao-YuChen,USA MariaG.Isaguliants,Sweden JoséL.Quiles,Spain
ZhaoZhongChong,USA VladimirJakovljevic,Serbia WalidRachidi,France
GiuseppeCirillo,Italy PeeterKarihtala,Finland KotaV.Ramana,USA
MassimoCollino,Italy EricE.Kelley,USA SidharthaD.Ray,USA
MarkCrabtree,UK KumKumKhanna,Australia AlessandraRicelli,Italy
ManuelaCurcio,Italy NeelamKhaper,Canada FranciscoJ.Romero,Spain
AndreasDaiber,Germany ThomasKietzmann,Finland H.P.VasanthaRupasinghe,Canada
FelipeDalPizzol,Brazil Jean-ClaudeLavoie,Canada GabrieleSaretzki,UK
FrancescaDanesi,Italy ChristopherHorstLillig,Germany HonglianShi,USA
DomenicoD’Arca,Italy PalomaB.Liton,USA CinziaSignorini,Italy
YolandadePablo,Sweden NageswaraMadamanchi,USA ShaneThomas,Australia
GrégoryDurand,France KennethMaiese,USA RosaTundis,Italy
JavierEgea,Spain TulliaMaraldi,Italy GiuseppeValacchi,Italy
ErsinFadillioglu,Turkey ReikoMatsui,USA JeannetteVasquez-Vivar,USA
QingpingFeng,Canada StevenMcAnulty,USA VictorM.Victor,Spain
GiuseppeFilomeni,Italy BrunoMeloni,Australia MichalWozniak,Poland
SwaranJ.S.Flora,India TrevorA.Mori,Australia Sho-ichiYamagishi,Japan
RodrigoFranco,USA RyuichiMorishita,Japan Liang-JunYan,USA
JoséLuísGarcía-Giménez,Spain AngeMouithys-Mickalad,Belgium GuillermoZalba,Spain
JanuszGebicki,Australia HassanObied,Australia JacekZielonka,USA
Contents
Antioxidant,Anti-Inflammatory,andMicrobial-ModulatingActivitiesofNutraceuticalsand
FunctionalFoods
IlariaPeluso,TheaMagrone,DéboraVillañoValencia,C.-Y.OliverChen,andMauraPalmery
Volume2017,ArticleID7658617,2pages
EffectofCocoaPolyphenolicExtractonMacrophagePolarizationfromProinflammatoryM1to
Anti-InflammatoryM2State
LauraDugo,MariaGiovannaBelluomo,ChiaraFanali,MarinaRusso,FrancescoCacciola,
MauroMaccarrone,andAnnaMariaSardanelli
Volume2017,ArticleID6293740,11pages
MyricitrinModulatesNADPHOxidase-DependentROSProductiontoInhibitEndotoxin-Mediated
𝑝ℎ𝑜𝑥
InflammationbyBlockingtheJAK/STAT1andNOX2/p47 Pathways
ShimeiQi,ZunyongFeng,QiangLi,ZhilinQi,andYaoZhang
Volume2017,ArticleID9738745,20pages
DevelopmentandInVitroEvaluationofanInnovative“DietaryFlavonoidSupplement”on
OsteoarthritisProcess
MariaRosariaLauro,LuciaCrascí,FrancescaSansone,VeneraCardile,AnnaMariaPanico,
andGiovanniPuglisi
Volume2017,ArticleID7503240,10pages
AntigenotoxicPropertiesofAgaricusblazeiagainstHydrogenPeroxideinHumanPeripheralBlood
Cells
LadaŽivković,SunčicaBorozan,AndreaČabarkapa,DijanaTopalović,UmmiCiptasari,
VladanBajić,andBiljanaSpremo-Potparević
Volume2017,ArticleID8759764,9pages
InfluenceofSynbioticsonSelectedOxidativeStressParameters
PaulinaKleniewskaandRafałPawliczak
Volume2017,ArticleID9315375,8pages
GutMicrobiotainaRatOralSensitizationModel:EffectofaCocoa-EnrichedDiet
MarionaCamps-Bossacoma,FranciscoJ.Pérez-Cano,ÀngelsFranch,andMargaridaCastell
Volume2017,ArticleID7417505,12pages
ImmuneProfileofObesePeopleandInVitroEffectsofRedGrapePolyphenolsonPeripheralBlood
MononuclearCells
TheaMagrone,EmilioJirillo,AnnaSpagnoletta,ManricoMagrone,MatteoAntonioRusso,SergioFontana,
FlaviaLaforgia,IlariaDonvito,AngeloCampanella,FrancoSilvestris,andGiovanniDePergola
Volume2017,ArticleID9210862,11pages
AChileanBerryConcentrateProtectsagainst PostprandialOxidativeStressandIncreasesPlasma
AntioxidantActivityinHealthyHumans
InesUrquiaga,FelipeÁvila,GuadalupeEcheverria,DrusoPerez, SebastianTrejo,andFedericoLeighton
Volume2017,ArticleID8361493,13pages
Antibacterial,Anti-Inflammatory,Antioxidant,andAntiproliferativePropertiesofEssentialOilsfrom
HairyandNormalRootsofLeonurussibiricusL.andTheirChemicalComposition
PrzemysławSitarek,PatriciaRijo,CatarinaGarcia,EwaSkała,DanutaKalemba,AdamJ.Białas,
JanuszSzemraj,DariuszPytel,
MonikaToma,HalinaWysokińska,andTomaszŚliwiński
Volume2017,ArticleID7384061,12pages
Antioxidant,Immunomodulating,andMicrobial-ModulatingActivitiesoftheSustainableand
EcofriendlySpirulina
AlbertoFinamore,MauraPalmery,SarraBensehaila,andIlariaPeluso
Volume2017,ArticleID3247528,14pages
RutinasaMediatorofLipidMetabolismandCellularSignalingPathwaysInteractionsinFibroblasts
AlteredbyUVAandUVBRadiation
AgnieszkaGgotek,PaulaRybałtowska-Kawałko,andElżbietaSkrzydlewska
Volume2017,ArticleID4721352,20pages
EGCGPreventsHighFatDiet-InducedChangesinGutMicrobiota,DecreasesofDNAStrandBreaks,
andChangesinExpressionandDNAMethylationofDnmt1andMLH1inC57BL/6JMaleMice
MarleneRemely,FranziskaFerk,SonjaSterneder,TaherehSetayesh,SylviaRoth,TatjanaKepcija,
RahilNoorizadeh,IreneRebhan,MartinaGreunz,JohannaBeckmann,Karl-HeinzWagner,
SiegfriedKnasmüller,andAlexanderG.Haslberger
Volume2017,ArticleID3079148,17pages
PhenolicCompositionandAntioxidantandAntiproliferativeActivitiesoftheExtractsofTwelve
CommonBean(PhaseolusvulgarisL.)EndemicEcotypesofSouthernItalybeforeandafterCooking
MariaNeveOmbra,Antoniod’Acierno,FilomenaNazzaro,RiccardoRiccardi,PatriziaSpigno,
MassimoZaccardelli,CatelloPane,MenaMaione,andFlorindaFratianni
Volume2016,ArticleID1398298,12pages
TheEssentialOilsofRhaponticumcarthamoidesHairyRootsandRootsofSoil-GrownPlants:Chemical
CompositionandAntimicrobial,Anti-Inflammatory,andAntioxidantActivities
EwaSkała,PatríciaRijo,CatarinaGarcia,PrzemysławSitarek,DanutaKalemba,MonikaToma,
JanuszSzemraj,DariuszPytel,HalinaWysokińska,andTomaszŚliwiński
Volume2016,ArticleID8505384,10pages
TheNutraceuticalDehydrozingeroneandItsDimerCounteractInflammation-andOxidative
Stress-InducedDysfunctionofInVitroCulturedHumanEndothelialCells:ANovelPerspectiveforthe
PreventionandTherapyofAtherosclerosis
ElisabettaProfumo,BrigittaButtari,DanielaD’Arcangelo,LaviniaTinaburri,
MariaAntoniettaDettori,DavideFabbri,GiovannaDelogu,andRacheleRiganò
Volume2016,ArticleID1246485,12pages
ComparativeAnalysisoftheInteractionbetweenDifferentFlavonoidsandPDIA3
FlaviaGiamogante,IlariaMarrocco,DonatellaRomaniello,MargheritaEufemi,SilviaChichiarelli,
andFabioAltieri
Volume2016,ArticleID4518281,12pages
SulforaphaneProtectsPancreaticAcinarCellInjurybyModulatingNrf2-MediatedOxidativeStressand
NLRP3InflammatoryPathway
ZhaojunDong,HaixiaoShang,YongQ.Chen,Li-LongPan,MadhavBhatia,andJiaSun
Volume2016,ArticleID7864150,12pages
PhytochemicalContentandPharma-NutritionStudyonEleutherococcussenticosusFruitsIntractum
DanielZałuski,MartaOlech,AgnieszkaGalanty,RobertVerpoorte,RafałKuźniewski,RenataNowak,
andAnnaBogucka-Kocka
Volume2016,ArticleID9270691,10pages
ReducedHMGB1-MediatedPathwayandOxidativeStressinResveratrol-TreatedDiabeticMice:A
PossibleMechanismofCardioprotectionofResveratrolinDiabetesMellitus
HanWu,Zhen-QiangSheng,JunXie,RanLi,LiangChen,
Guan-NanLi,LianWang,andBiaoXu
Volume2016,ArticleID9836860,10pages
Hindawi
Oxidative Medicine and Cellular Longevity
Volume 2017, Article ID 7658617, 2 pages
https://doi.org/10.1155/2017/7658617
Editorial
Antioxidant, Anti-Inflammatory, and Microbial-Modulating
Activities of Nutraceuticals and Functional Foods
1 2 3 4
Ilaria Peluso, Thea Magrone, Débora Villaño Valencia, C.-Y. Oliver Chen, and
5
Maura Palmery
1ResearchCentreforFoodandNutrition,CouncilforAgriculturalResearchandEconomics(CREA-AN),Rome,Italy
2DepartmentofBasicMedicalSciences,NeuroscienceandSensoryOrgans,UniversityofBari,Bari,Italy
3UniversidadCatólicaSanAntoniodeMurcia(UCAM),Murcia,Spain
4AntioxidantsResearchLaboratory,JeanMayerUSDAHumanNutritionCenteronAging,TuftsUniversity,Boston,MA,USA
5DepartmentofPhysiologyandPharmacology“V.Erspamer”,LaSapienzaUniversityofRome,Rome,Italy
CorrespondenceshouldbeaddressedtoIlariaPeluso;[email protected]
Received 11 May 2017; Accepted 11 May 2017; Published 10 September 2017
Copyright©2017IlariaPelusoetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,
whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited.
Oxidativestressisdefinedastheimbalancebetweenreactive Giamoganteetal.describedtheinteractionbetweenpolyphe-
oxygenspecies(ROS)formationandenzymaticandnonen- noliccompoundsandPDIA3,amoleculeassociatedtodiffer-
zymatic antioxidant defence favouring the former. Thus, enthumanpathologies.Inparticular,differentflavonoidsin
enhanced oxidative stress occurs when ROS formation is virtue of their chemical backbone structure conformation
increasedbyanarrayofexogenousandendogenousfactors, can bind to PDIA3, thus preventing its interaction with
for example, smoking, exposure to pollution, unhealthy DNA. ROS-induced DNA modifications can cause single-
diet,andchronic/low-gradeinflammation,whentheantiox- strandanddouble-strandbreaks,leadingtogenotoxiceffects.
idant defence capacity is compromised or both. Enhanced Thus, means that protect DNA from ROS and maintain
oxidative stress has been appreciated for its contribution DNA integrity have a chemopreventive potential. Agaricus
to the pathogenesis of noncommunicable diseases (e.g., blazei mushroom has been used in traditional medicine in
cardiovascular disease, metabolic syndrome, cancer, and theformofamedicinalextractforthepreventionandtreat-
brain disorders). Thus, to protect and prevent ROS-related mentofcancers.L.Živkovicetal.foundthatthismushroom
pathogenesis, enhancing antioxidant defence through diets displayedantigenotoxicpropertiesthatwereillustratedusing
appears to be a viable strategy. From that, the antioxidant Comet assay in human peripheral blood monocyte cells
activityandthephytochemicals’contentoffoodsandtradi- treatedwithH O andactedasastrong(cid:129)OHscavenger.
2 2
tional medicine plants are an interesting topic of research. H. Wu et al. discussed on the inhibition of the high-
Antioxidant and antiproliferative activities, related to the mobility box 1-mediated pathway which could contribute
content of phenolics, have been reported by M. N. Ombra to enhance anti-inflammatory and antifibrotic effects of
etal.fortwelvecommonbean(Phaseolusvulgaris)cultivars resveratrol on diabetic cardiomyopathy disease.
and by D. Zaluski et al. for the Eleutherococcus senticosus In addition to attacking susceptible macromolecules,
fruits intractum. I. Urquiaga et al. reported the antioxidant protein, DNA, and lipid, ROS modulate the expression of
activityofberries’concentrateinhumansaftermealanddis- genes that are regulated by nuclear factor erythroid 2-
cussed this result in terms of oxidative reactions that occur relatedfactor2(Nrf2)andnuclearfactor-kappaB(NF-κB).
duringdigestionandthethermalprocessingofredmeat. Forexample,Nrf2stimulatesthetranscriptionofantioxidant
In addition to acting as a ROS scavenger, polyphenols enzymesthroughtheantioxidant-responsiveelements(ARE)
interact with many molecular targets after consumption. F. and the activation of NF-κB elicits the gene expression of
2 OxidativeMedicineandCellularLongevity
inflammatorycytokines.Therefore,thereisaconcertedmod- Medicinal botanicals contain a diverse range of sub-
ulation of Nrf2 and NF-κB in inflammation and oxidative stancesexertingmultifacetedbioactionspotentiallybeneficial
stress. In this context, many nutraceuticals exert their anti- tohumanhealth. Leonurus sibiricus L.hasbeenreportedto
inflammatoryandantioxidanteffectsthroughtheinhibition possess cardioprotective, anticancer, analgesic, anti-inflam-
ofNF-κBandtheactivationofNrf2,respectively. matory, and neuroprotective activities. Adding the list of
The organosulfur compound sulforaphane (SFN) has thesebioactions,P.Sitareketal.examined theantibacterial,
beenevaluatedbyA.Dongetal.,whoobservedthatthiscom- anti-inflammatory,antioxidant,andantiproliferativeproper-
poundupregulatedNrf2expressionaswellasattenuatedthe ties of essential oils in Leonurus sibiricus L. Using several
inflammationprocess,byinhibitingNLRP3andNF-κBpath- in vitro platforms, they reported that essential oils, such as
ways, in acute pancreatitis, a pathology in which oxidative β-selinene, β-caryophyllene, and germacrene, contributed
stressiscloselyrelatedtotissuedamage. to the antibacterial, anti-inflammatory, antioxidant, and
A. Gegotek et al. observed the effects of the flavonoid antiproliferative properties of Leonurus sibiricus L. These
rutin in UV-irradiated fibroblasts, in which it reduced the results support future studies to examine their therapeutic
proinflammatory response measured by TNF-α and NF-κB applications, as well as their use as food preservative. The
levels; the oxidative response of xanthine and NADPH oxi- same research group also applied the same methodologies
dases involved in the generation of superoxide radicals also to examine antimicrobial, anti-inflammatory, and antioxi-
diminished, linked with an increase in Nrf2 expression. E. dant properties of a Rhaponticum carthamoide root. This
Profumo et al. reported that the anti-inflammatory effect of medicinalplanthasbeentraditionallyusedtotreatoverstrain
the nutraceutical Dehydrozingerone is in part due to the andweakness.ThestudyofE.Skalaetal.showedthatessen-
inhibition of the NF-κB pathway. On the other hand, the tialoilsofRhaponticumcarthamoide root exhibited antimi-
anti-inflammatory activity could be mediated also by other crobial,anti-inflammatory,andantioxidantactivities.
pathways. S. Qi et al. reported that myricitrin suppressed M.Remelyetal.reportedthebeneficialeffectsofEGCG
the production of free radicals and inflammatory cytokines on gut microbiota, stressing out their anti-inflammatory,
anddecreasedthemRNAlevelsofnitricoxidesynthase,the antioxidant, and epigenetic effects. M. Camps-Bossacoma
assemblyofthecomponentsoftheNADPHoxidaseenzyme etal.discussedonthepotentialtolerogenicroleofcocoadiet
complex (gp91 phox and p47 phox), and the phosphoryla- on gut microbiota in orally sensitized mice. L. Dugo et al.
tionofJanuskinases(JAKs)andsignaltransducerandacti- examinedtheeffectofcocoapolyphenolicextractonmacro-
vatoroftranscription1(STAT1). phagepolarizationfromtheproinflammatoryM1totheanti-
In order to overcome the problem of the low solubility inflammatoryM2state.Theyfoundinthisvitroexperiment
and bioavailability of polyphenols, M. R. Lauro et al. devel- thatcocoapolyphenolicextractnotonlysuppressedinflam-
oped and tested an eriocitrin/hydroxypropyl β-cyclodextrin mation of macrophages in the M2 state but also changed
inclusion complex as dietary flavonoid supplement to be macrophage metabolism by promoting oxidative pathways.
employedinosteoarthritis. However, the interpretation of the noted positive data
Inhumans,alsothesubjects’characteristicsinfluencethe must be taken with some cautions as cocoa polyphenols
responsetonutraceuticals.T.Magroneetal.reportedthatthe maynotbepresentinthesamechemicalformsafterabsorp-
peripheralbloodmononuclearcellsfromobeseandnormal- tion in the gastrointestinal tract. Further, future studies are
weightsubjectsrespondtothetreatmentwithredgrapepoly- warrantedtoidentifypathwaysormolecularsignalsinvolved
phenolsinvitroinadifferentmanner,inparticular,interms intheM1/M2switchofmacrophages.
ofIL-2andIL-21production.A.Finamoreetal.pointedout In conclusion, this special issue highlights the impor-
thattheeffectsofSpirulinaoncytokinesandonlymphocytes’ tance of using different methodological approaches in
proliferation depend on age, gender, and body weight dif- order to clarify the mechanisms of the potential health
ferences. Ageing and obesity are both associated with effects of nutraceuticals.
chronic low-grade inflammation, immune impairment, and
intestinaldysbiosis.Inthiscontext,oneofthemostpromis- Acknowledgments
ingareasforthedevelopmentoffunctionalfoodsliesinmod-
ulation of the immune system by the use of probiotics, Theeditorsthankallauthorswhosubmittedtheirresearchto
prebiotics, and synbiotics. Particularly, research examining this special issue. They also thank the many reviewers for
the interactions occurring between probiotics, prebiotics, theirvaluablecontributiontothisspecialissue.
andnutraceuticalsatthelevelsofthegutmicrobiotaandof
the gut-associated lymphoid tissue (GALT) is emerging. IlariaPeluso
Theseinteractionsarerelevantinthedesignofnutraceuticals TheaMagrone
andfunctionalfoodforthepreventionofnoncommunicable DéboraVillañoValencia
diseases associated with dysbiosis, oxidative stress, and C.-Y.OliverChen
chroniclow-gradeinflammation. MauraPalmery
P. Kleniewska and R. Pawliczak reported that a 7-week
synbiotics (Lactobacillus casei+Inulin) supplementation
improvedoxidativestressmarkers(malondialdehyde,hydro-
gen peroxide, glutathione, and free sulfhydryl groups) in
healthysubjects.