Antibacterial Coatings Based on Sonochemically Designed Surface Metal Nanofoams

17 Pages·2013·2.86 MB·English

by  Michael Switkes

Antibacterial coatings based on sonochemically
designed surface metal nanofoams, 2011, CLG
984267
NATO
Science for Peace and Security (SPS) Programme

Workshop on CBRN Defence – 22-24 October 2013 – Brussels

Emerging Security Challenges Division
NATO
Brussels, Belgium, 22.10.2013
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Project Description
Antibacterial coatings based on sonochemically designed surface metal
nanofoams, 2011, CLG 984267
• General overview:
Advances for a new generation of active metal surfaces with
feedback properties.
• Objectives:
Technologies for fabrication of surface metal nanofoams for active
chemicals storage by “green” ultrasound irradiation with combination with self-
assembly complexation between biocide and polyelectrolyte in open/close states
and formation of surface nanoreservoirs capable of long-term storage and
controllable release of the entrapped antimicrobial agents which provide a basis for
novel CNBR decontamination coatings.
• Expected outcomes comprehensible to the non-expert:
fabrication of
surface encapsulation systems capable of long-term storage and controllable
release of the entrapped antimicrobial agents which provide a basis for novel CNBR
decontamination coatings.
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What did we want to achieve ?

Nanoengineered Cavitation Interfaces
Understanding and controlling of
sonochemical reaction at solid surfaces
→ boost fundamental research,
control of nucleation
Bio-active Surface
Rational interface design
inorganic / polymeric / biological
→ antifouling systems, new medical therapies for
human transplants, stem-cell research

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What is special in sonochemistry?
“Hot spot” theory
 High Energy
 Fast
 Localised
 Sonoparameters → easy way to various structures
 Red/Ox vis-à-vis reaction in liquid
 Additive in liquid → single-step hybrids

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Focused ultrasonic treatment

* Lower left inset shows multibubble sonoluminecence
** Right inset shows ultrasonic unit for sonochemical modification, where 1) piezoceramic transducer; 2) booster; 3)
irradiating horn; 4) gas inlet; 5) thermoelement; 6) thermostated sonocell.
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Cavitation assisted porous surfaces


Surface capsules could be formed at higher intensity of sonication
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Surface capsules on metal surface
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Design of intelligent surfaces
TEM ultramicrocut of sonomodified metal
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Types of capsules
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Surface pore loading
“Surface” drug delivery: stimuli-responsive,
controlled, extended, multi-drug, with biosensing
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