Table Of ContentStem Cell Biology and Regenerative Medicine
Series Editor
Kursad Turksen
For furthervolumes:
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Hossein Baharvand Nasser Aghdami
•
Editors
Advances in Stem Cell
Research
Editors
Hossein Baharvand Nasser Aghdami
RoyanInstitute Regenerative Medicine
Universityof Science andCulture RoyanInstitutefor StemCell Biology
Tehran and Technology
Iran Tehran
Iran
ISBN 978-1-61779-939-6 ISBN 978-1-61779-940-2 (eBook)
DOI 10.1007/978-1-61779-940-2
SpringerNewYorkHeidelbergDordrechtLondon
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To the memory of Dr. Saeid Kazemi Ashtiani,
a wonderful colleague, a great stem cell
biologist, and an inspirational advocate of
stem cell research in Iran
To our professors, teachers, students, and
families
Preface
Keeping in line with the current focus that personalized medicine should be the
future medicine, stem cells have received tremendous attention. In recognition of
the growing excitement and potential of stem cells for both the advancement of
biology and future clinical applications, we felt it timely to edit this book to
addressanddiscussthecurrentadvancesandtopicsonstemcells,coveringaspects
from stem cell nano-engineering, pluripotent stem cells, and cellular reprogram-
ming to regenerative medicine. We are pleased to provide Advances in Stem Cell
Research as a timely and comprehensive overview.
By itself, the field of stem cells has generated tremendous interest; however,
development in this area will also pave the way for a breakthrough within
regenerativemedicine.Inparallel,scientificdevelopmentsinthepost-genomicera
andachievementsinsystemsbiologywillallowforthenecessarydevelopmentof
personalized medicine.
We want to sincerely thank all authors who have contributed to this book for
their dedicated efforts and their excellent contributions. We hope that you, as a
reader, will enjoy this volume.
We are also grateful to Dr. Hamid Gourabi, Dr. Abdolhossein Shahverdi, and
Dr. Ahmad Vosough Dizaj for having faith in and supporting us throughout this
project. We also wish to acknowledge the great support provided by many at
Humana Press. A special thank you goes to our dedicated colleagues at Royan
Institute for Stem Cell Biology and Technology who, with their tireless commit-
ment toward stem cellresearch,have become crucial factors inencouraging usto
edit this book. We are grateful to Zahra Maghari for her help with collecting the
chapters and in the follow-up.
vii
Contents
1 ES Cell Lines from Tetraploid Mouse Blastocysts . . . . . . . . . . . . 1
Martin J. Pfeiffer, Martin Stehling, Anna Jauch and Michele Boiani
2 The Significance of Culture Adaptation of Embryonic Stem Cells
for Regenerative Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Neil J. Harrison, Duncan Baker and Peter W. Andrews
3 Biomanufacturing Human Pluripotent Stem Cells
for Therapeutic Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Xiaojun Lian and Sean P. Palecek
4 hESC-Derived Hepatocytes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Iman Saramipoor Behbahan and Mark A. Zern
5 Advances in Induced Pluripotent Stem Cell Biology. . . . . . . . . . . 67
Ali Seifinejad
6 iPS Cells: New Applications for Metabolic Liver Diseases . . . . . . 85
Tobias Cantz, Abbas Beh-Pajooh and Malte Sgodda
7 Vascular Differentiation of Human Pluripotent Stem Cells. . . . . . 97
Helena Vazão, Mário Grãos and Lino Ferreira
8 Mechanism of MicroRNA-Mediated Global DNA
Demethylation in Human iPS Cells. . . . . . . . . . . . . . . . . . . . . . . 117
Shi-Lung Lin
9 Microtechnological Approaches in Stem Cell Science. . . . . . . . . . 135
Faramarz Edalat, Jae Min Cha, Hojae Bae, Sam Manoucheri,
Sang Bok Kim and Ali Khademhosseini
ix
x Contents
10 Application of Micro/Nanotechnology to Stem Cell Research
and Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167
Amir R. Aref
11 Spermatogonial Stem Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191
Hossein Azizi, Sabine Conrad, Thomas Skutella
and Irma Virant-Klun
12 Cellular Reprogramming and Fate Conversion . . . . . . . . . . . . . . 211
Masaki Ieda
13 Omics in Stem Cell Therapy: The Road Ahead. . . . . . . . . . . . . . 227
Kyunghee Byun, Goo-Bo Jeong, Trevor N. Collingwood
and Bonghee Lee
14 Microglia: The Bodyguard and the Hunter
of the Adult Neurogenic Niche . . . . . . . . . . . . . . . . . . . . . . . . . . 245
Jorge Valero, Maria Francisca Eiriz, Tiago Santos, Ismael Neiva,
Raquel Ferreira and João O. Malva
15 Immunosuppressive Properties of Mesenchymal Stromal Cells. . . 281
Francesco Lanza, Diana Campioni, Endri Mauro,
Annalisa Pasini and Roberta Rizzo
16 Cellular Therapy for Hematology Malignancies: Allogeneic
Hematopoietic Stem Transplantation, Graft-Versus-Host Disease,
and Graft Versus Leukemia Effects. . . . . . . . . . . . . . . . . . . . . . . 303
James L. M. Ferrara and Pavan Reddy
17 Cardiac Versus Non-Cardiac Stem Cells to Repair the Heart:
The Role of Autocrine/Paracrine Signals. . . . . . . . . . . . . . . . . . . 367
Manlio Vinciguerra, Vincenzo Lionetti, Carlo Ventura
and Nadia Rosenthal
18 Adult Neurogenesis in Alzheimer’s Disease and Therapies. . . . . . 383
Philippe Taupin
Author’s Biography. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 395
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 397
Contributors
Nasser Aghdami Cell Science Research Center, Royan Institute for Stem Cell
Biology and Technology, ACECR, Tehran, Iran
Peter W. Andrews Department of Biomedical Science, Centre for Stem Cell
Biology, The University of Sheffield, Sheffield, UK
Amir R. Aref Department of Biological Engineering, Massachusetts Institute of
Technology,Cambridge,MAUSA;HarvardMedicalSchool,Dana-FarberCancer
Institute, Boston, MA, USA
Hossein Azizi Institute for Anatomy and Cell Biology, University of Heidelberg,
Heidelberg, Germany
HojaeBaeDepartmentofMedicine,CenterforBiomedicalEngineering,Harvard
Medical School, Brigham and Women’s Hospital, Cambridge, MA, USA;
Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, Cambridge, MA, USA
Duncan Baker Sheffield Diagnostic Genetic Services, Sheffield Children’s NHS
Trust, Sheffield, UK
HosseinBaharvand Department ofStem Cells and DevelopmentalBiology, Cell
Science Research Center,RoyanInstitutefor StemCellBiologyandTechnology,
ACECR, Tehran, Iran; Department of Developmental Biology, University of
Science and Culture, ACECR, Tehran, Iran
Abbas Beh-Pajooh Stem Cell Biology, Cluster-of-Excellence, REBIRTH,
Hannover Medical School, Hannover, Germany
Michele Boiani Max Planck Institute for Molecular Biomedicine, Münster,
Germany
Kyunghee Byun Center for Genomics and Proteomics and Stem Cell Core
Facility,LeeGilYaCancerandDiabetesInstitute,GachonUniversityofMedicine
xi
xii Contributors
andScience,Incheon,Korea;DepartmentofAnatomyandCellBiology,Graduate
SchoolofMedicine,GachonUniversityofMedicineandScience,Incheon,Korea
Diana Campioni Hematology Section, University of Ferrara, Ferrara, Italy
Tobias Cantz Stem Cell Biology, Cluster-of-Excellence, REBIRTH, Hannover
Medical School, Hannover, Germany
Trevor N. Collingwood Sigma-Aldrich, Inc., St. Louis, MO, USA
SabineConradInsituteofAnatomy,UniversityofTübingen,Tübingen,Germany
Faramarz Edalat Department of Medicine, Center for Biomedical Engineering,
HarvardMedicalSchool,BrighamandWomen’sHospital,Cambridge,MA,USA;
Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, Cambridge, MA, USA
Maria Francisca Eiriz Faculty of Medicine, Center for Neuroscience and Cell
Biology, University of Coimbra, Coimbra, Portugal
James L. M. Ferrara Professor of Medicine and Pediatrics, Combined Bone
Marrow Transplant Program, University of Michigan Cancer Center, Ann Arbor,
MI, USA
Lino Ferreira CNC—Center for Neuroscience and Cell Biology, University of
Coimbra, Coimbra, Portugal
RaquelFerreiraFacultyofMedicine,CenterforNeuroscienceandCellBiology,
University of Coimbra, Coimbra, Portugal
Mario Grãos Biocant—Center of Innovation in Biotechnology, Cantanhede,
Portugal
Neil J. Harrison Department of Biomedical Science, Centre for Stem Cell
Biology, The University of Sheffield, Sheffield, UK
Masaki Ieda Department of Clinical and Molecular Cardiovascular Research,
Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan; Department of
Cardiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan
Anna Jauch Institute of Human Genetics, University Heidelberg, Heidelberg,
Germany
Goo-Bo Jeong Department of Anatomy and Cell Biology, Graduate School of
Medicine, Gachon University of Medicine and Science, Incheon, Korea
Ali Khademhosseini Wyss Institute for Biologically Inspired Engineering at
Harvard University, Boston, MA, USA
Sang Bok Kim Department of Medicine, Center for Biomedical Engineering,
HarvardMedicalSchool,BrighamandWomen’sHospital,Cambridge,MA,USA;
Contributors xiii
Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, Cambridge, MA, USA
Francesco Lanza Hematology and Stem Cell Unit, Cremona, University of
Ferrara, Ferrara, Italy
Bonghee Lee Center for Genomics and Proteomics and Stem Cell Core Facility,
Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and
Science, Incheon, Korea; Department of Anatomy and Cell Biology, Graduate
SchoolofMedicine,GachonUniversityofMedicineandScience,Incheon,Korea
XiaojunLianDepartmentofChemicalandBiologicalEngineering,Universityof
Wisconsin, Madison, WI, USA
Shi-Lung Lin Division of Regenerative Medicine, WJWU & LYNN Institute for
Stem Cell Research, Santa Fe Springs, CA, USA
Vincenzo Lionetti Laboratory of Medical Science, Institute of Life Sciences,
Scuola Superiore Sant’Anna, Pisa, Italy; Laboratory of Molecular Biology and
Stem Cell Engineering, National Institute of Biostructures and Biosystems,
University of Bologna, Bologna, Italy; Department of Physiology, New York
Medical College, Valhalla, NY, USA
João O. Malva Laboratory of Biochemistry and Cell Biology, Faculty of
Medicine, University of Coimbra, Coimbra, Portugal
Sam Manoucheri Department of Medicine, Center for Biomedical Engineering,
HarvardMedicalSchool,BrighamandWomen’sHospital,Cambridge,MA,USA;
Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, Cambridge, MA, USA
Endri Mauro Hematology and Stem Cell Unit, Cremona, University of Ferrara,
Ferrara, Italy
Jae Min Cha Department of Medicine, Center for Biomedical Engineering,
HarvardMedicalSchool,BrighamandWomen’sHospital,Cambridge,MA,USA;
Harvard-MIT Division of Health Sciences and Technology, Massachusetts
Institute of Technology, Cambridge, MA, USA
Ismael Neiva Faculty of Medicine, Center for Neuroscience and Cell Biology,
University of Coimbra, Coimbra, Portugal
SeanP.PalecekDepartmentofChemicalandBiologicalEngineering,University
of Wisconsin, Madison, WI, USA
AnnalisaPasiniHematologyandStemCellUnit,Cremona,UniversityofFerrara,
Ferrara, Italy
Martin J. Pfeiffer Max Planck Institute for Molecular Biomedicine, Münster,
Germany
