Table Of ContentAdvances in Particle Therapy
Series in Medical Physics and Biomedical Engineering
Series Editors: John G. Webster, E. Russell Ritenour, Slavik Tabakov,
and Kwan-Hoong Ng
Recent books in the series:
Clinical Radiotherapy Physics with MATLAB: A Problem-Solving Approach
Pavel Dvorak
Advances in Particle Therapy: A Multidisciplinary Approach
Manjit Dosanjh and Jacques Bernier (Eds)
Radiotherapy and Clinical Radiobiology of Head and Neck Cancer
Loredana G. Marcu, Iuliana Toma-Dasu, Alexandru Dasu, and Claes Mercke
Problems and Solutions in Medical Physics: Diagnostic Imaging Physics
Kwan-Hoong Ng, Jeannie Hsiu Ding Wong, and Geoffrey D. Clarke
Advanced and Emerging Technologies in Radiation Oncology Physics
Siyong Kim and John W. Wong (Eds)
A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data
Issam El Naqa (Ed)
Advanced MR Neuroimaging: From Theory to Clinical Practice
Ioannis Tsougos
Quantitative MRI of the Brain: Principles of Physical Measurement, Second edition
Mara Cercignani, Nicholas G. Dowell, and Paul S. Tofts (Eds)
A Brief Survey of Quantitative EEG
Kaushik Majumdar
Handbook of X-ray Imaging: Physics and Technology
Paolo Russo (Ed)
Graphics Processing Unit-Based High Performance Computing in Radiation Therapy
Xun Jia and Steve B. Jiang (Eds)
Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs
Todd A. Kuiken, Aimee E. Schultz Feuser, and Ann K. Barlow (Eds)
Emerging Technologies in Brachytherapy
William Y. Song, Kari Tanderup, and Bradley Pieters (Eds)
Environmental Radioactivity and Emergency Preparedness
Mats Isaksson and Christopher L. Rääf
The Practice of Internal Dosimetry in Nuclear Medicine
Michael G. Stabin
Advances in Particle Therapy
A Multidisciplinary Approach
Edited by
Manjit Dosanjh
Jacques Bernier
CRC Press
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Contents
Foreword, ix
About the Editors, xi
Contributors, xiii
CHAPTER 1 ◾ From Röntgen Rays to Carbon Ion Therapy: The Evolution
of Modern Radiation Oncology 1
K. SEIDENSAAL AND J. DEBUS
CHAPTER 2 ◾ Radiobiology and Hadron Therapy: What Do We Know
and What Do We Need to Know? 9
ELEANOR A. BLAKELY AND MANJIT DOSANJH
CHAPTER 3 ◾ Challenges Surrounding Relative Biological Effectiveness
for Particle Therapy: Where Do We Go from Here? 27
BLEDDYN JONES, DAVID R. GROSSHANS AND RADHE MOHAN
CHAPTER 4 ◾ Advances in Beam Delivery Techniques and Accelerators
in Particle Therapy 37
MARCO SCHIPPERS
CHAPTER 5 ◾ Requirements for Setting Up a Particle Therapy Centre 55
RAMONA MAYER, STANISLAV VATNITSKY AND BERND MÖßLACHER
CHAPTER 6 ◾ Imaging and Particle Therapy: Current Status and
Future Perspectives 67
G. LANDRY, G. DEDES, M. PINTO AND K. PARODI
CHAPTER 7 ◾ Why Particle Therapy Rather than Photon Therapy or How
to Integrate the Decision into Multimodal Management 95
JOACHIM WIDDER AND RICHARD PÖTTER
v
vi ◾ Contents
CHAPTER 8 ◾ Role of Multidisciplinary Collaborative Network for
Advancing Cancer Therapy 107
MANJIT DOSANJH AND JACQUES BERNIER
CHAPTER 9 ◾ Long-Term Outcomes and Prognostic Factors in Patients
with Indications for Particle Therapy in Sarcomas 115
BEATE TIMMERMANN AND STEPHANIE E. COMBS
CHAPTER 10 ◾ Proton Therapy for Paediatric Patients 131
MASASHI MIZUMOTO, YOSHIKO OSHIRO AND HIDEYUKI SAKURAI
CHAPTER 11 ◾ Normal Tissue Complication Probability Reduction
in Advanced Head and Neck Cancer Patients Using
Proton Therapy 145
JACQUES BALOSSO, VALENTIN CALUGARU, ABDULHAMID CHAIKH AND JULIETTE THARIAT
CHAPTER 12 ◾ The Model-Based Approach to Select Patients for
Proton Therapy and to Validate Its Added Value 155
JOHANNES A. LANGENDIJK, JOHN H. MADURO, ANNE P.G. CRIJNS AND
CHRISTINA T. MUIJS
CHAPTER 13 ◾ Overview of Carbon-Ion Radiotherapy in Japan 169
HIROHIKO TSUJII AND TADASHI KAMADA
CHAPTER 14 ◾ Particle Therapy Clinical Trials: Perspectives from
Europe, Japan and the United States 181
CAI GRAU, DAMIEN CHARLES WEBER, JOHANNES A. LANGENDIJK, JAMES D. COX,
TADASHI KAMADA AND HIROHIKO TSUJII
CHAPTER 15 ◾ Role of Particle Therapy in Future Radiotherapy Practice 193
ROBERTO ORECCHIA
CHAPTER 16 ◾ Health Economics: Cost, Cost- Effectiveness and
Budget Impact of Particle Therapy 203
YOLANDE LIEVENS AND MADELON JOHANNESMA
CHAPTER 17 ◾ B ig Data-Based Decision Support Systems for
Hadron Therapy 221
YVONKA VAN WIJK, CARY OBERIJE, ERIK ROELOFS AND PHILIPPE LAMBIN
Contents ◾ vii
CHAPTER 18 ◾ C ERN Collaborations in Hadron Therapy and
Future Accelerators 231
UGO AMALDI AND ADRIANO GARONNA
CHAPTER 19 ◾ A ddressing Global Challenges for Radiation Therapy:
From ‘C’ to Shining ‘C’ (Cobalt to Carbon) and the
‘Radiation Rotary’ 259
C. NORMAN COLEMAN, JEFFREY BUCHSBAUM AND DAVID A. PISTENMAA
INDEX, 273
Foreword
At a time when radiotherapy is undergoing profound changes considerable efforts
have been made to give hadron therapy the place it deserves in the battle against can-
cer. For too many years and in many countries, numerous particle therapy programmes
have remained at the level of discussion only: indeed, uncertainties surrounding their real
therapeutic indices and fears about a low cost/benefit ratio have led many national health
authorities to remain careful about investing in these technologies. However, recent, sig-
nificant developments in both the diagnostic and therapeutic spheres, linked to hadrons in
a direct or indirect manner, have propelled major institutions and laboratories involved in
translational and clinical research to intensify their R&D programmes on particle therapy.
To be effective, this evolution requires an intense and continuous exchange of informa-
tion and educational programmes among the various scientific communities. The main
objective of this textbook is to be part of this effort both by strengthening the knowledge
of readers in their own field of expertise (e.g., biology, physics and clinics) and by increas-
ing their familiarity with the know-how developed in the other domains of hadron therapy
with which they are called to interact and collaborate.
Towards this aim, the first part of this textbook places hadrons in their historical, bio-
logical and technological contexts. In the second part, particular emphasis has been given
to the interactions between imaging and particle therapy, as well as to the advantages that
can be expected from multi-disciplinary collaborative network in this domain. The most
recent developments in clinical practice have been described in depth, with special atten-
tion paid to various examples of hadron therapy indications, also in consideration of the
expected risks of complications in normal tissues and to issues related to health economics.
The final section is dedicated to various future projections, and revisits a number of
fundamental aspects in precision medicine and future technologies. We hope the exhaus-
tive review of the most burning challenges in radiotherapy that concludes the textbook will
help increase understanding of the real dimension and place of radiation sciences in this
era of globalisation.
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