talytic c−h functionalization of aromat nitrogen compounds directed by the -pyridylsulfonyl gro

377 Pages·2013·3.18 MB·Spanish

Facultad de Ciencias
Departamento de Química Orgánica

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NNIITTRROOGGEENN CCOOMMPPOOUUNNDDSS DDIIRREECCTTEEDD BBYY TTHHEE
2--PYRIDYLSULFONYL GROUP

BEATRIZ URONES RUANO

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Catedrático (UAM)
Dr. Ramón Gómez Arrayás
Profesor Titular (UAM)
Madrid, Mayo de 2013

This PhD Thesis has been done at the Department of Organic Chemistry at the
Universidad Autónoma de Madrid under the supervison of Prof. Dr. Juan Carlos Carretero and
Prof. Dr. Ramón Gómez Arrayás.
This work was supported by the Ministerio de Ciencia e Innovación (MICINN, CTQ2009-
07791/BQU), the Ministerio de Economía y Competitividad (MINECO, CTQ 2012-35790) and
the Consejería de Educación de la Comunidad de Madrid (programme AVANCAT, S2009/PPQ-
1634). B.U. thanks the MICINN for a FPU predoctoral fellowship and N.R. for a contract
through her Marie Curie Career Integration Grant - CIG (CHAAS-304085).

It is difficult to overstate my gratitude to my Ph.D. supervisor, Prof. Juan Carlos Carretero,
who have helped and supported me along this long but fulfilling road.
To Ramón. whose expertise, understanding, and patience, added considerably to my
graduate experience. I appreciate his vast knowledge and skill in many areas and his guidence
in writing reports. Thanks for making things easier until the last minute.
A very special thanks goes out to Dr. Jorge Fernández Molina, without whose motivation
and encouragement I would not have considered to do a PhD. Also thank you very much for
being “tol rato tol tiempo en descontacto total” and never let me down.
When I started this adventure, my mum gave me a great advice: It’s going to be a hard
trip, so stick to people that loves you and support you! Maria, you are one of a kind! Thanks for
being my family in Madrid, support me, encourage me and also celebrate the good moments.
You have been a true friend all this time (esto es para siempre!).
Nuria, there isn’t enough words to thank you and to express all my gratitutde for everything
you have done for me. You were the last one arriving but you have became such a great friend.
THANK YOU for being just the way you are. You are the only few people that can me make me
laugh when I’m stressed…. Thanks for all your help and support and never let me down! I
couldn’t have done it without you, that’s for sure… I love you!!!
I must also acknowledge my colleagues in the Organic Chemistry Department for their
support and good moments, in special to the members of my research group for the exchanges
of knowledge, skills, and venting of frustration during my graduate program, which helped
enrich the experience.
Appreciation also goes out to those who provided me with helpful advice at times of critical
need; Nana, Ester, Mariona, Isa ….. Primi! Thanks for your permanent smile.
I would also like to thank my family for the support they provided me through my entire life
and in particular, I must acknowledge my grands without whose love, encouragement and faith,
I would not have embarked on this adventure.

“On ne voit bien qu'avec le coeur; l'essentiel est invisible pour les yeux”
Antoine de Saint-Exupéry, Le Petit Prince

“The whole problem with the world is that fools and fanatics are alsways so certain of
themselves and wisers full of doubts”
Bertrand Russell

To my family, in special to my grandparents