Rare Hematological Malignancies

435 Pages·2008·51.5 MB·English

by  Richard T. Silver (auth.)

Rare Hematological Malignancies
Cancer Treatment and Research
Steven T. Rosen, M.D., Series Editor
Pienta, K.J. (ed.): Diagnosis and Treatment of Genitourinary Malignancies. 1996. ISBN 0-7923-4164-3.
Arnold, A.J. (ed.): Endocrine Neoplasms. 1997. ISBN 0-7923-4354-9.
Pollock, R.E. (ed.): Surgical Oncology. 1997. ISBN 0-7923-9900-5.
Verweij, J., Pinedo, H.M., Suit, H.D. (eds): Soft Tissue Sarcomas: Present Achievements and Future
Prospects. 1997. ISBN 0-7923-9913-7.
Walterhouse, D.O., Cohn, S. L. (eds): Diagnostic and Therapeutic Advances in Pediatric Oncology.
1997. ISBN 0-7923-9978-1.
Mittal, B.B., Purdy, J.A., Ang, K.K. (eds): Radiation Therapy. 1998. ISBN 0-7923-9981-1.
Foon, K.A., Muss, H.B. (eds): Biological and Hormonal Therapies of Cancer. 1998. ISBN 0-7923-9997-8.
Ozols, R.F. (ed.): Gynecologic Oncology. 1998. ISBN 0-7923-8070-3.
Noskin, G. A. (ed.): Management of Infectious Complications in Cancer Patients. 1998. ISBN 0-7923-8150-5.
Bennett, C. L. (ed.): Cancer Policy. 1998. ISBN 0-7923-8203-X.
Benson, A. B. (ed.): Gastrointestinal Oncology. 1998. ISBN 0-7923-8205-6.
Tallman, M.S., Gordon, L.I. (eds): Diagnostic and Therapeutic Advances in Hematologic Malignancies.
1998. ISBN 0-7923-8206-4.
von Gunten, C.F. (ed.): Palliative Care and Rehabilitation of Cancer Patients. 1999. ISBN 0-7923-8525-X
Burt, R.K., Brush, M.M. (eds): Advances in Allogeneic Hematopoietic Stem Cell Transplantation.
1999.
ISBN 0-7923-7714-1.
Angelos, P. (ed.): Ethical Issues in Cancer Patient Care 2000. ISBN 0-7923-7726-5.
Gradishar, W.J., Wood, W.C. (eds): Advances in Breast Cancer Management. 2000. ISBN 0-7923-7890-3.
Sparano, J. A. (ed.): HIV & HTLV-I Associated Malignancies. 2001. ISBN 0-7923-7220-4.
Ettinger, D. S. (ed.): Thoracic Oncology. 2001. ISBN 0-7923-7248-4.
Bergan, R. C. (ed.): Cancer Chemoprevention. 2001. ISBN 0-7923-7259-X.
Raza, A., Mundle, S.D. (eds): Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia 2001.
ISBN: 0-7923-7396.
Talamonti, M. S. (ed.): Liver Directed Therapy for Primary and Metastatic Liver Tumors. 2001.
ISBN 0-7923-7523-8.
Stack, M.S., Fishman, D.A. (eds): Ovarian Cancer. 2001. ISBN 0-7923-7530-0.
Bashey, A., Ball, E.D. (eds): Non-Myeloablative Allogeneic Transplantation. 2002. ISBN 0-7923-7646-3.
Leong, S. P.L. (ed.): Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and
Colon Cancer. 2002. ISBN 1-4020-7013-6.
Andersson , B., Murray D. (eds): Clinically Relevant Resistance in Cancer Chemotherapy. 2002.
ISBN 1-4020-7200-7.
Beam, C. (ed.): Biostatistical Applications in Cancer Research. 2002. ISBN 1-4020-7226-0.
Brockstein, B., Masters, G. (eds): Head and Neck Cancer. 2003. ISBN 1-4020-7336-4.
Frank, D.A. (ed.): Signal Transduction in Cancer. 2003. ISBN 1-4020-7340-2.
Figlin, R. A. (ed.): Kidney Cancer. 2003. ISBN 1-4020-7457-3.
Kirsch, M.; Black, P. McL. (ed.): Angiogenesis in Brain Tumors. 2003. ISBN 1-4020-7704-1.
Keller, E.T., Chung, L.W.K. (eds): The Biology of Skeletal Metastases. 2004. ISBN 1-4020-7749-1.
Kumar, R. (ed.): Molecular Targeting and Signal Transduction. 2004. ISBN 1-4020-7822-6.
Verweij, J., Pinedo, H.M. (eds): Targeting Treatment of Soft Tissue Sarcomas. 2004. ISBN 1-4020-7808-0.
Finn, W.G., Peterson, L.C. (eds.): Hematopathology in Oncology. 2004. ISBN 1-4020-7919-2.
Farid, N. (ed.): Molecular Basis of Thyroid Cancer. 2004. ISBN 1-4020-8106-5.
Khleif, S. (ed.): Tumor Immunology and Cancer Vaccines. 2004. ISBN 1-4020-8119-7.
continued after Index
Stephen M. Ansell, MD, PhD
Editor
Rare Hematological
Malignancies
Stephen M. Ansell, MD, PhD
Associate Professor of Medicine
Mayo Clinic, College of Medicine
200 First Street SW
Rochester, Minnesota, USA
Series Editor:
Steven T. Rosen
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, IL
USA
ISBN-13: 978-0-387-73743-0 e-ISBN-13: 978-0-387-73744-7
Library of Congress Control Number: 2007932231
© 2008 Springer Science + Business Media, LLC
All rights reserved. This work may not be translated or copied in whole or in part without the written
permission of the publisher (Springer Science + Business Media, LLC, 233 Spring Street, New York, NY
10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in
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Preface
Advances in diagnostic techniques and therapeutic modalities have brought about
significant progress in the management of many hematologic malignancies. For the
practicing clinician these changes are occurring at a rapid rate and it is difficult to
keep informed of all the new information. Therefore, most physicians focus on the
major diagnostic and therapeutic changes in common cancers, and it is often a
challenge to stay up to date on the advances in the less common malignancies.
Furthermore, it is difficult to find the new information in a timely fashion when
seeing patients with an uncommon or unusual hematologic malignancy. In this
book, we have assembled data on rare hematologic malignancies to provide a
c oncise resource for practicing oncologists. Each chapter provides information on
the biology of the various rare hematologic diseases but also focuses on the latest
therapeutic advances. Because of the paucity of clinical trials in most of these
d iseases, the authors have not only summarized the literature but also provided their
own expertise regarding management of patients. We trust that this book will be
helpful to physicians seeing patients with uncommon hematologic malignancies,
and will also be of benefit to patients by providing the treating physicians with
r ecommendations concerning the optimal management of diseases that are uncom-
monly seen in their practice.
Stephen M. Ansell, MD, PhD
Division of Hematology
Mayo Clinic
v
Contents
Contributors ................................................................................................... ix
1 Polycythemia Vera and Other Polycythemia Syndromes ..................... 1
Richard T. Silver
2 Primary Myelofi brosis ............................................................................. 29
Ayalew Tefferi
3 Essential Thrombocythemia.................................................................... 51
Guido Finazzi
4 Chronic Eosinophilic Leukemia/
Hypereosinophilic Syndrome .................................................................. 69
Jason Gotlib
5 Chronic Myelomonocytic Leukemia ...................................................... 107
Miloslav Beran
6 The 5q– Syndrome ................................................................................... 133
Aristoteles A.N. Giagounidis and Carlo Aul
7 Rare Acute Leukemias ............................................................................. 149
Xavier Georges Thomas
8 Hairy Cell Leukemia ................................................................................ 193
Paul Timothy Fanta and Alan Saven
9 Waldenstrom’s Macrogloblinemia/
Lymphoplasmacytic Lymphoma............................................................. 211
Steven P. Treon, Evdoxia Hatjiharissi,
and Giampaolo Merlini
vii
viii Contents
10 Rare B-cell Lymphomas: Primary Mediastinal, Intravascular,
and Primary Effusion Lymphoma ........................................................ 243
Kerry J. Savage
11 Lymphomatoid Granulomatosis ........................................................... 265
Ryan B. Lundell, Roger H. Weenig,
and Lawrence E. Gibson
12 Posttransplant Lymphoproliferative Disorders .................................. 273
Thomas M. Habermann
13 Castleman Disease .................................................................................. 293
Angela Dispenzieri
14 Rare T-Cell Lymphomas........................................................................ 331
Ana Maria Molina and Steven M. Horwitz
15 CD30+ Diseases: Anaplastic Large-Cell Lymphoma
and Lymphomatoid Papulosis ............................................................... 349
Peter Borchmann
16 Nodular Lymphocyte Predominant Hodgkin’s Lymphoma ............... 367
Michelle A. Fanale and Anas Younes
17 Langerhans Cell Histiocytosis ............................................................... 383
Karen L. Chang and David S. Snyder
18 Systemic Mastocytosis ........................................................................... 399
Peter Valent
Index ................................................................................................................ 421
Contributors
Stephen M. Ansell
Mayo Clinic College of Medicine, Rochester, MN
Carlo Aul
St. Johannes Hospital, Duisburg, Germany
Milosav Beran
University of Texas M.D. Anderson Cancer Center, Houston TX
Peter Borchmann
University of Cologne, Cologne, Germany
Karen L. Chang
City of Hope National Medical Center, Duarte, CA
Angela Dispenzieri
Mayo Clinic College of Medicine, Rochester, MN
Michelle A. Fanale
University of Texas M.D. Anderson Cancer Center, Houston, TX
Paul T. Fanta
Scripps Clinic, La Jolla, CA
Guido Finazzi
Ospedali Riuniti, Bergamo, Italy
Aristoteles A.N. Giagounidis
St. Johannes Hospital, Duisburg, Germany
Lawrence E. Gibson
Mayo Clinic College of Medicine, Rochester, MN
Jason Gotlib
Stanford Cancer Center, Stanford, CA
Thomas M. Habermann
Mayo Clinic College of Medicine, Rochester, MN
ix
x Contributors
Evdoxia Hatjiharissi
Dana Farber Cancer Institute, Boston, MA
Steven M. Horwitz
Memorial Sloan Kettering Cancer Center, New York, N Y
Ryan B. Lundell
Mayo Clinic College of Medicine, Rochester, MN
Giampaolo Merlini
Amyloidosis Center, Biotechnology Research Laboratories,
Fondazione IRCCS Policlinico San Matteo and Department of Biochemistry,
University of Pavia, Italy
Ana Maria Molina
Memorial Sloan Kettering Cancer Center, New York, NY
Kerry J. Savage
British Columbia Cancer Agency, Vancouver, Canada
Alan Saven
Scripps Clinic,. La Jolla, CA
Richard T. Silver
Weill Cornell Medical University, New York, NY
David S. Snyder
City of Hope National Medical Center, Duarte, CA
Ayalew Tefferi
Mayo Clinic College of Medicine, Rochester, MN
Xavier G. Thomas
Edouard Herriot Hospital, Lyon, France
Steven P. Treon
Dana Farber Cancer Institute, Boston, MA
Peter Valent
Medical University of Vienna, Vienna, Austria
Roger H. Weenig
Mayo Clinic College of Medicine, Rochester, MN
Anas Younes
University of Texas M.D. Anderson Cancer Center, Houston, TX