Table Of ContentPROTEIN KINASES
Edited by Gabriela Da Silva Xavier
Protein Kinases
Edited by Gabriela Da Silva Xavier
Published by InTech
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Copyright © 2012 InTech
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First published June, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Protein Kinases, Edited by Gabriela Da Silva Xavier
p. cm.
ISBN 978-953-51-0640-1
Contents
Preface IX
Chapter 1 The Target of Rapamycin: Structure and Functions 1
Chang-Chih Wu, Po-Chien Chou and Estela Jacinto
Chapter 2 SNF1/AMP-Activated Protein Kinases:
Genes, Expression and Biological Role 41
Dmytro O. Minchenko and Oleksandr H. Minchenko
Chapter 3 Alternating Phosphorylation with O-GlcNAc Modification:
Another Way to Control Protein Function 63
Victor V. Lima and Rita C. Tostes
Chapter 4 Technologies for the Use of Protein
Kinases into Medical Applications 79
Yoshiki Katayama
Chapter 5 Role of Kinases and Phosphatases
in Host-Pathogen Interactions 99
Horacio Bach
Chapter 6 Pathogen Strategies to Evade Innate Immune Response:
A Signaling Point of View 123
Bruno Miguel Neves, Maria Celeste Lopes and Maria Teresa Cruz
Chapter 7 Phosphorylation-Regulated Cell Surface
Expression of Membrane Proteins 165
Yukari Okamoto and Sojin Shikano
Chapter 8 Regulation of Retrotransposition
of Long Interspersed Element-1
by Mitogen-Activated Protein Kinases 187
Yukihito Ishizaka, Noriyuki Okudaira and Tadashi Okamura
Chapter 9 Connexins as Substrates for Protein Kinases
and Phosphoprotein Phosphatases 199
José L. Vega, Elizabeth Baeza, Viviana M. Berthoud and Juan C. Sáez
VI Contents
Chapter 10 Protein Phosphatases Drive Mitotic Exit 215
Megan Chircop
Chapter 11 Regulations and Functions of ICK/MAK/MOK – A Novel
MAPK-Related Kinase Family Linked to Human Diseases 229
Zheng “John” Fu
Chapter 12 Protein Kinases and Protein Phosphatases
as Participants in Signal Transduction of Erythrocytes 249
Ana Maneva and Lilia Maneva-Radicheva
Chapter 13 Role of Protein Kinase Network in
Excitation-Contraction Coupling in Smooth Muscle Cell 287
Etienne Roux, Prisca Mbikou and Ales Fajmut
Chapter 14 Regulation of Na+/H+ Exchanger Isoform 3
by Protein Kinase A in the Renal Proximal Tubule 321
Adriana Castello Costa Girardi and Luciene Regina Carraro-Lacroix
Chapter 15 cGMP-Dependent Protein Kinase
in the Regulation of Cardiovascular Functions 337
Yuansheng Gao, Dou Dou, Xue Qin, Hui Qi and Lei Ying
Chapter 16 The Crucial Role of c-Src
Tyrosine Kinase in Bone Metabolism 357
Barbara Peruzzi, Nadia Rucci and Anna Teti
Chapter 17 The ERK MAPK Pathway
in Bone and Cartilage Formation 381
Takehiko Matsushita and Shunichi Murakami
Chapter 18 Protein Kinases and Pancreatic Islet Function 399
Gabriela Da Silva Xavier
Chapter 19 Raf Serine/Threonine Protein Kinases:
Immunohistochemical Localization
in the Mammalian Nervous System 423
András Mihály
Chapter 20 Protein Kinases in Spinal Plasticity:
A Role for Metabotropic Glutamate Receptors 443
J. Russell Huie and Adam R. Ferguson
Chapter 21 Protein Kinases and Pain 459
Mani Indiana Funez, Fabiane Hiratsuka Veiga de Souza,
José Eduardo Pandossio
and Paulo Gustavo Barboni Dantas Nascimento
Preface
Proteins are the work horses of the cell. As regulators of protein function, protein kinases
are involved in the control of cellular functions via intricate signalling pathways,
allowing for fine tuning of physiological functions. This book is a collaborative effort,
with contribution from experts in their respective fields, reflecting the spirit of
collaboration - across disciplines and borders - that exists in modern science. Here, we
review the existing literature and, on occasions, provide novel data on the function of
protein kinases in various systems. We also discuss the implications of these findings in
the context of disease, treatment, and drug development.
Gabriela Da Silva Xavier
Non-Clinical Lecturer in Cell Biology/Physiology, Department of Medicine,
Faculty of Medicine, Imperial College London,
UK
