Prevalence and spread of antibiotic resistant microorganisms in a cross border region

142 Pages·2013·1.82 MB·English

Prevalence and spread of antibiotic resistant
microorganisms in a cross border region
Citation for published version (APA):
van der Donk, C. F. M. (2013). Prevalence and spread of antibiotic resistant microorganisms in a cross
border region. [Doctoral Thesis, Maastricht University]. Uitgeverij BOXPress.
https://doi.org/10.26481/dis.20130605cd
Document status and date:
Published: 01/01/2013
DOI:
10.26481/dis.20130605cd
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Download date: 20 Feb. 2023
Prevalence and spread of
antibiotic resistant microorganisms
in a cross border region

Christel van der Donk
ISBN: 978-90-8891-592-5
Cover design: Christel van der Donk en Proefschriftmaken.nl - Uitgeverij BOXPress
Printed and published: Proefschriftmaken.nl - Uitgeverij BOXPress

© C.F.M. van der Donk, Eindhoven 2013
All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any
means, electronic or mechanical including photocopying, recording or any information storage or
retrieval system, without written permission from the author, or, when appropriate from the
publisher of the publications.

The research in this thesis was financially supported by:
Provincie Limburg - the Netherlands, Ministerium für Wirtschaft, Energie, Bauen, Wohnen und
Verkehr des Landes Nordrhein-Westfalen - Germany, Ministerium der Deutschsprachige
Gemeinschaft Belgiens - Belgium, Provincie Limburg - Belgium, Wallonie - Belgium, Rheinland-
Westfalen - Germany, Interreg and the Euregio Maas-Rijn with support of the European fund for
regional development (EFRO)
and
the Dutch Working Party on Antibiotic Policy.

Printing of this thesis was financially supported by the Netherlands Society of Medical
Microbiology (NVMM) and the Royal Netherlands Society for Microbiology (KNVM)
Prevalence and spread of
antibiotic resistant microorganisms
in a cross border region

PROEFSCHRIFT

Ter verkrijging van de graad van doctor
aan de Universiteit Maastricht,
op gezag van de Rector Magnificus,
prof. dr. L.L.G. Soete,
volgens het besluit van het College van Decanen,
in het openbaar te verdedigen
op woensdag 5 juni 2013 om 14.00 uur

door

Christina Francina Maria van der Donk

geboren op 19 november 1984 te ’s-Hertogenbosch
Promotor
em. prof. dr. C.A. Bruggeman

Co-promotor
dr. E.E. Stobberingh

Beoordelingscommissie
prof. dr. J.F.M. Metsemakers
prof. dr. C.A. Hoebe
prof. dr. H.A. Verbrugh (Erasmus MC, Rotterdam)
dr. D.C.J.J. Bergmans
Aan ons pap en mam

Contents

Abbreviations 8

Map of the Euregion Meuse-Rhine 11

Chapter 1 General introduction and Aim & Outline of the thesis 13

Chapter 2 Antimicrobial resistance and spread of multi drug resistant 37
Escherichia coli isolates collected from nine urology
services in the Euregion Meuse-Rhine

Chapter 3 Prevalence and spread of multi drug resistant Escherichia 49
coli isolates among nursing home residents in the southern
part of the Netherlands

Chapter 4 Prevalence and spread of multi drug resistant E. coli 61
including ST131 in different patient populations in the
Euregion Meuse-Rhine

Chapter 5 Resistance and population structure of Staphylococcus 79
aureus in nursing homes in the border region of the
Netherlands and Germany

Chapter 6 Is living in a border region a risk for a high prevalence of 95
resistance?

Chapter 7 A 12 year (1998-2009) antibiotic resistance surveillance of 107
Klebsiella pneumoniae collected from intensive care and
urology patients in 14 Dutch hospitals

Chapter 8 General discussion, summary and samenvatting 115

Dankwoord 131

Curriculum vitae 137

List of publications 139
Abbreviations

AMC amoxicillin-clavulanic acid
AMO amoxicillin
ATC anatomical therapeutic chemical classification system
ATCC American type culture collection
AZI azitromycin
B Belgium
BURP based upon repeat pattern
BURST based upon related sequence types
CAZ ceftazidime
CA-MRSA community-associated MRSA
CC clonal complex
CIP ciprofloxacin
CFA clonal frame analysis
CFM cefixime
CFX cefotaxime
CLI clindamycin
CTX-M cefotaxime-Munich
CXM cefuroxime
DDD defined daily dosage
DI diversity index
ERY erytromycin
ESBL extended spectrum beta-lactamase
EUCAST European committee on antimicrobial susceptibility testing
FDR false discovery rate
FEP cefepime
FUC fusidic acid
G Germany
GEN gentamicin
GP general practice
HA-MRSA hospital associated MRSA
ICU intensive care unit
IMP imipenemase
IPM imipenem
KPC Klebsiella pneumoniae carbapenemase
L Limburg
MDR multi drug resistant
MEM meropenem
MIC minimal inhibitory concentration
MLST multi locus sequence typing
MLVA multi locus variable number tandem repeat analysis
MRSA methicillin resistance Staphylococcus aureus
MSSA methicillin susceptible Staphylococcus aureus
8
MUMC Maastricht University Medical Centre
MUP mupirocin
NDM New Delhi metallo-beta-lactamase
NH nursing home
NIT nitrofurantoin
NL the Netherlands
NOR norfloxacin
NT not tested
OXA oxacillin
OXA oxacillinase
PBP penicillin binding protein
PCR polymerase chain reaction
PEN penicillin
PFGE pulsed field gel electrophoresis
PIP piperacillin
QUI quinolones
SCCmec Staphylococcal cassette chromosome
SHV sulfhydryl variable
spa staphylococcal protein A gene
spa-CC spa clonal complex
ST sequence type
SXT trimethoprim-sulfamethoxazole
TAZ piperacillin-tazobactam
TEM Temoneira
TOB tobramycin
TRIM trimethoprim
UPGMA unweighted pair group method with arithmetic averages
URO urology services
UPEC uropathogenic Escherichia coli
UTI urinary tract infection
VIM Verona integron-encoded metallo-beta-lactamase
WHO world health organization
9