Table Of ContentHYPOTENSIVE PEPTIDES
SYMPOSIUM CHAIRMEN: F. Sic uteri and E.G. Erdos
ORGANIZING COMMITTEE: N. Back, E.G. Erdos and F. Sicuteri
Assistants to the Organizing Committee: G. Franchi and M. Fanciullacci
HONORARY COMMITTEE
G. G. ARCH! -Rector of University, Florence
D. BOVET -Institute of Pharmacology, University of Sassari
L. CALIFANO -Institute of General Pathology, University of Naples
J.H.GADDUM * -Depatrment of Pharmacology, University of Edinburgh
E. GREPPI -Department of Medicine, University of Florence
E. KATCHALSKI -Weizmann Institute, Israel
L. LAGORIO -Mayor of Florence
A. LUNEDEI -Dean of the School of Medicine of the University of Florence
D.H.MURRAY -Dean of the School of Pharmacy, Buffalo, State U. of N. Y .
M. ROCHA e SILVA -Chairman, Dept. of Pharmacol. U. of S. Paulo, Ribeirao Preto,
S. Paulo, Brazil
* Deceased
SPONSORED BY The State University of New York at Buffalo
and
The University of Florence
HYPOTENSIVE PEPTIDES
Proceedings of the International Symposium
October 25-29, 1965, Florence, Italy
Ervin G. Erdos
Professor of Pharmacology
University of Oklahoma School of Medicine
Editor-in-Chief
Nathan Back
Professor of Biochemical Pharmacology
State University of New York at Buffalo
Federigo Sicuteri
Professor of Medicine
University of Florence
and
A nne F. Wilde
New Haven, Connecticut
Technical Editor
t
SPRINGER-VERLAG • BERLIN. HEIDELBERG • NEW YORK - 19• •
ISBN-13: 978-3-642-94967-8 e-TSBN-13: 978-3-642-94965-4
DOT: 10.1007/978-3-642-94965-4
All rights, especially that of translation into foreign languages, reserved.
It is also forbidden to reproduce this book, either whole or in part, by photomechanical
means (photostat, microfilm and/or microcard) or by other procedure without written
permission from Springer-Verlag New York Inc.
Library of Congress Catalog Card Number 66-21083
Title No. 1379
@ 1966 by Springer-Verlag New York Inc.
Softcover reprint of the hardcover 1st edition 1966
List of Contributors
AKIMOTO, SETSUKO, Laboratory of Physiological Chemistry,
Tokyo College of SCience, Tokyo, Japan
AMARO, J., Department of Pharmacology, Tulane University
School of Medicine, New Orleans, Louisiana
AMUNDSEN, EGIL, Institute of Physiology, UniversityofOslo,
Norway
ANASTASI, A., Farmitalia Research Laboratories, Milan, Italy
ARMSTRONG, DESIREE, Middlesex Hospital Medical School,
University of London, England
ATSUMI, T., Institute for Cardiovascular Diseases and Depart
ment of MediCine, Tokyo Medical and Dental University,
Tokyo, Japan
AUNGST, C. W., Division of Medicine, Roswell Park Memorial
Institute, Buffalo, New York
AUSTEN, K. FRANK, Massachusetts General Hospital, Boston,
Massachusetts
BACK, N., Department of Biochemical Pharmacology, The
state University of New York at Buffalo, School of Pharm
acy, Buffalo, New York
BAROOS, T., The state University of New York at Buffalo,
School of Pharmacy, Buffalo, New York
BARLOW, B., The state University of New York at Buffalo,
School of Pharmacy, Buffalo, New York
BARROSO, JADER, Departamento de Bioquimica, Faculdade de
Medicina, Universidade de Minas GeraiS, Belo Horizonte,
Brazil
BAUER, G., Pharmakologisches Institut der Universitiit Inns
bruck, Austria
BEACHAM, J., The Robert Robinson and Physiological Labora
tories, Liverpool University, England
BENTLEY, P. H., The Robert Robinson and Physiological Lab
oratories, Liverpool University, England
BERETTA ANGUISSOLA, A., Institute of Medical Pathology
and Clinical Methodology, University of Turin, Italy
BERNARDI, L., Istituto Ricerche Farmitalia, Milan, Italy
v
vi LIST OF CONTRIBUTORS
BERT, G., Institute of Medical Pathology and Clinical Meth
odology, University of Turin, Italy
BERTACCINI, GIU LIO , Institute of Pharmacology, University
of Parma, Italy
BOBBIN, R., Department of Pharmacology, Tulane University
School of Medicine, New Orleans, Louisiana
BOREHAM, P. F. L., Nuffield Institute of Comparative Medi
cine, The Zoological Society of London, England
BORGHETTI, A., Instituto de Patologia Speciale Medica, Uni
versita di Parma, Italy
CAMPUS, S., Institute of Medical Pathology and Clinical Meth
odology, University of Turin, Italy
CANO, G., Department of Pharmacology, Tulane University
School of Medicine, New Orleans, Louisiana
CEI, J. M., Institute of Biology, National University of Cuyo,
Mendoza, Argentina
CHIANDUSSI, L., Institute of Medical Pathology and Clinical
Methodology, University of Turin, Italy
COLLIER, H. 0. J., Department of Pharmacological Research,
Parke-Davis & Co., Hounslow, Middlesex, England
CRAIG, LYMAN C., The Laboratories of The Rockefeller Uni
versity, New York, New York
DE CARO, G., Istituto di Patologia Speciale Medica, University
of Parma, Italy
DEL BIANCO, P. L., Center for the Study of Headaches, Gen
eral Medical Clinic of the University of Florence, Italy
Dl MATTEI, PIETRO, Institute of Pharmacology, University
of Rome, Italy
DINIZ, CARLOS R., Departamento de Bioquimica, Faculdade
de Medicina, Universidade de Minas Gerais, Belo Hori
zonte, Brazil
DYER, DONALD C., Department of Pharmacology, Kansas
University Medical Center, Kansas City, Kansas
EDERY, H., Israel Institute for Biological Research, Ness
Ziona, Israel
EISEN, V., Department of Pharmacology, The Middlesex Hos
pital Medical School, London, England
ERDOS, ERVIN G., Department of Pharmacology, University
of Oklahoma School of Medicine, Oklahoma City, Oklahoma
ERSPAMER, V., Institute of Pharmacology of the University of
Parma, Italy
FANCIULLACCI, M., Center for the Study of Headaches, Gen
eral Medical Clinic of the University of Florence, Italy
LIST OF CONTRIBUTORS vii
FERREffiA, S. H., Department of Pharmacology, Faculty of
Medicine, University of sao Paulo, Ribeirao Preto, sao
Paulo, Brazil
FERUGLIO, F. S., Institute of Medical Pathology and Clinical
Methodology, University of Turin, Italy
FRANCHI, G., Center for the study of Headaches, General
Medical Clinic of the University of Florence, Italy
FREGNAN, G. B., Farmitalia Research Laboratories, Milan,
Italy
FRITZ, H., Klinisch-Chemisches Institut an der Chirurgischen
Klinik der Universitat Miinchen, Germany
FUJITA, T., Institute for Cardiovascular Diseases and Depart
ment of Medicine, Tokyo Medical and Dental University,
Tokyo, Japan
FUKUSHIMA, HffiOKO, Laboratory of Physiological Chemistry,
Tokyo College of Science, Tokyo, Japan
FURANO, E., Laboratory of Clinical Biochemistry, National
Heart Institute, Bethesda, Maryland
GASPARRI, F., Istituto di Clinica Ostetrica della Universita
degli studi di Firenze, Florence, Italy
GLADNER, J. A., Laboratory of Biophysical Chemistry, Na
tional Institute of Arthritis and Metabolic Diseases, Be
thesda, Maryland
GLASSER, A. H., Farmitalia Research Laboratories, Milan,
Italy
GOODWIN, L. G., Nuffield Institute of Comparative MediCine,
The Zoological SoCiety of London, England
GREENBAUM, LOWELL M., Department of Pharmacology,
College of PhYSicians and Surgeons, Columbia University,
New York, New York
GREGORY, R. A., The Robert Robinson and Physiological
Laboratories, Liverpool University, England
GREPPI, E., Clinica Medica dell' Universita, Florence, Italy
GUTH, P. S., Department of Pharmacology, Tulane University
School of MediCine, New Orleans, Louisiana
HABER, EDGAR, Department of Medicine, Harvard Medical
School, Boston, Massachusetts
HABERMANN, E., Institut fUr Pharmakologie der Universitiit,
Wlirzburg, Germany
HAEFELY, W., Department of Experimental MediCine, F. Hoff
mann-La Roche & Co. Ltd., Basle, Switzerland
HAUGE, A., Institute of PhYSiology, University of Oslo, Nor
way
viii LIST OF CONTRIBUTORS
HEIZMANN, A., Department of Pharmacology, University of
TUbingen, Germany
HILTON, S. M., Department of Physiology, University of Birm
ingham, England
HOCHSTRASSER, K., Klinisch-Chemisches Institut an der Chir
urgischen Klinik der Universitat Miinchen, Munich, Ger
.. many
HURLIMANN, A., Department of Experimental Medicine, F.
Hoffmann-La Roche & Co. Ltd., Basle, Switzerland
ISHIOKA, T., Institute for Cardiovascular Diseases and De
partment of Medicine, Tokyo Medical and Dental Univer
sity, Tokyo, Japan
IW ANA GA, SADAAKI, The Institute for Protein Research, Osaka
University, Osaka, Japan
KA TCHALSKI, EPHRAIM, Department of Biophysics, Weizmann
Institute of Science, Rehovoth, Israel
KEELE, C. A., Department of Pharmacology, The Middlesex
Hospital Medical School, London, England
KENNER, G. W., The Robert Robinson and Physiological
Laboratories, Liverpool University, England
KONZETT, H., Pharmakologisches Institut der Universitiit
Innsbruck, Austria
KRIVOY, W., Department of Pharmacology, Baylor University
College of MediCine, Texas Medical Center, Houston, Texas
KROEGER, D. C., Department of Pharmacology, University of
Texas Dental Branch, Houston, Texas
LA GRECA, G., Istituto di Farmacologia dell' Universita di
Parma, Italy
LANZ, P., F. Hoffmann-LaRoche & Co. Ltd., Basle, Switzerland
LEMBECK, F., Department of Pharmacology, University of
Tiibingen, Germany
LUBKE, KLAUS, ScheringAG, Hauptlaboratorium, Berlin, West
Germany
LUNDE, P. K. M., Institute of Physiology, University of Oslo,
Norway
MAC LEOD, J. K., The Robert Robinson and Physiological
Laboratories, Liverpool University, England
MARES-GUIA, MARCOS, Departamento de Bioquimica, Facul..;
dade de Medicina, Universidade de Minas Gerais, Belo
Horizonte, Brazil
MARGOLIS, J., Children's Medical Research Foundation, Royal
Alexandra Hospital for Children, Camperdown, New South
Wales, Australia
LIST OF CONTRIBUTORS ix
MEINARDI, HARRY, The Laboratories of The Rockefeller
University, New York, New York
MELMON, KENNETH L., Departments of Medicine and Phar
macology, The Section of Clinical Pharmacology and Car
diovascular Research Institute, University of California,
San Francisco, California
MERRIFIELD, R. B., The Rockefeller University, New York,
New York
MILLS, G. L., The Middlesex Hospital Medical School, Uni
versity of London, England
MORIWAKI, CHIAKI, Laboratory of Physiological Chemistry,
Tokyo College of SCience, Tokyo, Japan
MORIYA, HIROSHI, Laboratory of Physiological Chemistry,
Tokyo College of SCience, Tokyo, Japan
NAGASAWA, SHIGEHARU, The Institute for Protein Research,
Osaka University, Osaka, Japan
NUMANO, F., Institute for Cardiovascular Diseases and De
partment of MediCine, Tokyo Medical and Dental University,
Tokyo, Japan
OATES, JOHN A., Departments of Medicine and Pharmacology,
The Division of Clinical Pharmacology, Vanderbilt Uni
versity, Nashville, Tennessee
PANDOLFO, G., Institute of Medical Pathology and Clinical
Methodology, University of Turin, Italy
PEREIRA, ANIBAL A., Departamento de Bioquimica, Facul
dade de Medicina, Universidade de Minas Gerais, Belo
Horizonte, Brazil
PERITI, P., Istituto di Farmacologia della Universita degli
studi di Firenze, Florence, Italy
PIERCE, JACK V., Laboratory of MetabOlism, National Heart
Institute, Bethesda, Maryland
PISANO, J. J., Laboratory of Clinical Biochemistry, National
Heart Institute, Bethesda, Maryland
PRADO, J. L., Escola Paulista de Medicina, Sao Paulo, Brazil
SARDESAI, V. M., The Robert S. Marx Laboratories of the
Department of Surgery, Wayne state University School of
Medicine, Detroit, Michigan
SATO, TADASHI, The Institute for Protein Research, Osaka
University, Osaka, Japan
SCHACHTER, M., Department of PhYSiology, University of
Alberta, Edmonton, Alberta, Canada
SCHRODER, E., Schering AG, Hauptlaboratorium, Berlin,
West Germany
x LIST OF CONTRIBUTORS
SEIDEL, G., Department of Pharmacology, University of
TUbingen, Germany
SHEPPARD, R. C., The Robert Robinson and Physiological
Laboratories, Liverpool University, England
SHIMAMOTO, T., Institute for Cardiovascular Diseases and
Department of Medicine, Tokyo Medical and Dental Uni
versity, Tokyo, Japan
SICUTERI, F., Center for the study of Headaches, General
Medical Clinic of the University of Florence, Italy
SPRAGG, JOCELYN, Department of Medicine, Harvard Medical
School, Boston, Massachusetts
STEGER, R., The Roswell Park Memorial Institute, Buffalo,
New York
STERN, P., Department of Pharmacology, Medical Faculty,
Sarajevo, Yugoslavia
STEWART, JOHN MORROW, The Rockefeller University, New
York, New York
STORMER, E., Biological and Medical Research Division,
Sandoz Ltd., Basle, Switzerland
SUZUKI, TOMOJI, Institute for Protein Research, Osaka Uni
versity, Osaka, Japan
TAMURA, Z., Laboratory of Clinical Biochemistry, National
Heart Institute, Bethesda, Maryland
THAL, A. P., The Robert S. Marx Laboratories of the De
partment of Surgery, Wayne state University School of
Medicine, Detroit, Michigan
THOENEN, H., Department of Experimental Medicine, F. Hoff
mann-La Roche & Co. Ltd., Basle, Switzerland
TRAUTSCHOLD, 1., Klinisch-Chemisches Institut an der Chir
urgischen Klinik der Universitiit Miinchen, Munich, Ger
many
TSUKADA, G. A., The state University of New York at Buffalo,
School of Pharmacy, Buffalo, New York
UDENFRIED, S., Laboratory of Clinical Biochemistry, National
Heart Institute, Bethesda, Maryland
VICK, ROBERT L., Department of Physiology, Baylor Univer
sity College of Medicine, Texas Medical Center, Houston,
Texas
VOGLER, K, F. Hoffmann-La Roche & Co. Ltd., Basle, Swit
zerland
VOGT, W., Department of Pharmacology, Max-Planck Institut
fur Experimentelle Medizin, GOttingen, Germany
