Williams Hematology

4050 Pages·2009·46.15 MB·English

Williams Hematology 6th edition (November 28, 2000): by Ernest Beutler M.D.,
Marshall A. Lichtman M.D., Barry S. Coller M.D., Thomas J. Kipps M.D. Ph.D., Uri
Seligsohn M.D. (Editor) By McGraw-Hill Professional
By OkDoKeY
Williams Hematology
CONTENTS
NOTICE
EDITORS
CONTRIBUTORS
PREFACE
SI UNIT CONVERSION TABLE
COLOR PLATES
PART I
CLINICAL EVALUATION OF THE PATIENT
CHAPTER 1 APPROACH TO THE PATIENT
Ernest Beutler / Marshall A. Lichtman / Barry S. Coller / Thomas J. Kipps / Uri Seligsohn / William J. Williams
CHAPTER 2 EXAMINATION OF THE BLOOD
Daniel H. Ryan
CHAPTER 3 EXAMINATION OF THE MARROW
Daniel H. Ryan
PART II
GENERAL HEMATOLOGY
CHAPTER 4 STRUCTURE OF THE MARROW AND THE HEMATOPOIETIC MICROENVIRONMENT
Camille N. Abboud / Marshall A. Lichtman
CHAPTER 5 THE LYMPHOID TISSUES
Thomas J. Kipps
CHAPTER 6 THE INFLAMMATORY RESPONSE
Jeffrey S. Warren / Peter A. Ward
CHAPTER 7 HEMATOLOGY OF THE NEWBORN
George B. Segel / James Palis
CHAPTER 8 HEMATOLOGY IN THE AGED
Marshall A. Lichtman / William J. Williams
PART III
MOLECULAR AND CELLULAR HEMATOLOGY
CHAPTER 9 GENETIC PRINCIPLES AND MOLECULAR BIOLOGY
Ernest Beutler
CHAPTER 10 CYTOGENETICS AND GENE REARRANGEMENT
Michelle M. LeBeau
CHAPTER 11 APOPTOSIS
Roberta A. Gottlieb
CHAPTER 12 CELL CYCLE REGULATION AND HEMATOLOGICAL DISORDERS
Mathias Schmid / Dennis A. Carson
CHAPTER 13 THE CLUSTER OF DIFFERENTIATION ANTIGENS
Thomas J. Kipps
CHAPTER 14 HEMATOPOIETIC STEM CELLS, PROGENITOR CELLS, AND CYTOKINES
Peter J. Quesenberry / Gerald A. Colvin
CHAPTER 15 IMMUNE ACCESSORY MOLECULES AND SIGNAL TRANSDUCTION
Theodore J. Yun / Edward A. Clark
PART IV
THERAPEUTIC PRINCIPLES
CHAPTER 16 PHARMACOLOGY AND TOXICITY OF ANTINEOPLASTIC DRUGS
Bruce A. Chabner / Wyndham Wilson / Jeffrey Supko
CHAPTER 17 TREATMENT OF INFECTIONS IN THE IMMUNOCOMPROMISED HOST
Steven M. Beutler
CHAPTER 18 ALLOGENEIC AND AUTOLOGOUS HEMATOPOIETIC CELL TRANSPLANTATION
Robert S. Negrin / Karl G. Blume
CHAPTER 19 GENE THERAPY
Christopher E. Walsh / Johnson M. Liu / Arthur W. Nienhuis
CHAPTER 20 THE USE OF VENOUS ACCESS DEVICES
McDonald K. Horne, III / Donna Jo Mayo / Alison G. Freifeld
CHAPTER 21 PAIN MANAGEMENT
Richard B. Patt / Neil M. Ellison
PART V
THE ERYTHROCYTE
CHAPTER 22 MORPHOLOGY OF THE ERYTHRON
Brian S. Bull
CHAPTER 23 COMPOSITION OF THE ERYTHROCYTE
Ernest Beutler
CHAPTER 24 IRON METABOLISM
Virgil F. Fairbanks / Ernest Beutler
CHAPTER 25 METABOLIC ASPECTS OF FOLIC ACID AND COBALAMIN
Bernard M. Babior
CHAPTER 26 ENERGY METABOLISM AND MAINTENANCE OF ERYTHROCYTES
Ernest Beutler
CHAPTER 27 THE RED CELL MEMBRANE
Patrick G Gallagher / Bernard G. Forget
CHAPTER 28 STRUCTURE AND FUNCTION OF HEMOGLOBIN
Helen M. Ranney / Vijay Sharma
CHAPTER 29 PRODUCTION AND DESTRUCTION OF ERYTHROCYTES
Ernest Beutler
CHAPTER 30 CLINICAL MANIFESTATIONS AND CLASSIFICATION OF ERYTHROCYTE DISORDERS
Allan J. Erslev
CHAPTER 31 APLASTIC ANEMIA
Richard K. Shadduck
CHAPTER 32 PURE RED CELL APLASIA
Allan J. Erslev
CHAPTER 33 ANEMIA OF CHRONIC RENAL FAILURE
Jaime Caro / Allan J. Erslev
CHAPTER 34 ANEMIA OF ENDOCRINE DISORDERS
Allan J. Erslev
CHAPTER 35 THE CONGENITAL DYSERYTHROPOIETIC ANEMIAS
Ernest Beutler
CHAPTER 36 PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
Ernest Beutler
CHAPTER 37 THE MEGALOBLASTIC ANEMIAS
Bernard M. Babior
CHAPTER 38 IRON DEFICIENCY
Virgil F. Fairbanks / Ernest Beutler
CHAPTER 39 ANEMIA DUE TO OTHER NUTRITIONAL DEFICIENCIES
Ernest Beutler
CHAPTER 40 ANEMIA ASSOCIATED WITH MARROW INFILTRATION
Allan J. Erslev
CHAPTER 41 ANEMIA OF CHRONIC DISEASE
Allan J. Erslev
CHAPTER 42 DISORDERS OF IRON STORAGE AND TRANSPORT
Virgil F. Fairbanks / David J. Brandhagen
CHAPTER 43 HEREDITARY SPHEROCYTOSIS, ELLIPTOCYTOSIS, AND RELATED DISORDERS
Patrick G. Gallagher / Bernard G. Forget
CHAPTER 44 ACANTHOCYTOSIS, STOMATOCYTOSIS, AND RELATED DISORDERS
Patrick G. Gallagher
CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME
ABNORMALITIES
Ernest Beutler
CHAPTER 46 THE THALASSEMIAS
David J. Weatherall
CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS
Ernest Beutler
CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN
Ernest Beutler
CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS
Ernest Beutler
CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA
Allan J. Erslev
CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA
Jose Martinez
CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA
Allan J. Erslev
CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS
Ernest Beutler
CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS
Ernest Beutler
CHAPTER 55 ACQUIRED HEMOLYTIC ANEMIA DUE TO WARM-REACTING AUTOANTIBODIES
Charles H. Packman
CHAPTER 56 CRYOPATHIC HEMOLYTIC SYNDROMES
Charles H. Packman
CHAPTER 57 DRUG-RELATED IMMUNE HEMOLYTIC ANEMIA
Charles H. Packman
CHAPTER 58 ALLOIMMUNE HEMOLYTIC DISEASE OF THE NEWBORN
Jayashree Ramasethu / Naomi L. C. Luban
CHAPTER 59 ACUTE BLOOD LOSS ANEMIA
Robert S. Hillman / Chaim Hershko
CHAPTER 60 HYPERSPLENISM AND HYPOSPLENISM
Allan J. Erslev
CHAPTER 61 POLYCYTHEMIA
Ernest Beutler
CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA
Shigeru Sassa
CHAPTER 63 HEREDITARY AND ACQUIRED SIDEROBLASTIC ANEMIAS
Ernest Beutler
PART VI
NEUTROPHILS, EOSINOPHILS, BASOPHILS AND MAST CELLS
CHAPTER 64 MORPHOLOGY OF NEUTROPHILS, EOSINOPHILS, AND BASOPHILS
Dorothy Ford Bainton
CHAPTER 65 COMPOSITION AND METABOLISM OF NEUTROPHILS
Ernest Beutler
CHAPTER 66 PRODUCTION, DISTRIBUTION, AND FATE OF NEUTROPHILS
Bernard M. Babior / David W. Golde
CHAPTER 67 FUNCTIONS OF NEUTROPHILS
James E. Smolen / Laurence A. Boxer
CHAPTER 68 EOSINOPHILS AND THEIR DISORDERS
A. J. Wardlaw / A. Barry Kay
CHAPTER 69 BASOPHILS AND MAST CELLS AND THEIR DISORDERS
Stephen J. Galli, Dean D. Metcalfe, Ann M. Dvorak
CHAPTER 70 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF NEUTROPHIL DISORDERS
Marshall A. Lichtman
CHAPTER 71 NEUTROPENIA AND NEUTROPHILIA
David C. Dale
CHAPTER 72 NEUTROPHIL DISORDERS: QUALITATIVE ABNORMALITIES OF THE NEUTROPHIL
Laurence A. Boxer
PART VII
MONOCYTES AND MACROPHAGES
CHAPTER 73 MORPHOLOGY OF MONOCYTES AND MACROPHAGES
Steven D. Douglas / Wen-Zhe Ho
CHAPTER 74 BIOCHEMISTRY AND FUNCTION OF MONOCYTES AND MACROPHAGES
Robert I. Lehrer / Tomas Ganz
CHAPTER 75 PRODUCTION, DISTRIBUTION, AND FATE OF MONOCYTES AND MACROPHAGES
Tomas Ganz / Robert I. Lehrer
CHAPTER 76 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF DISORDERS OF MONOCYTES AND MACROPHAGES
Marshall A. Lichtman
CHAPTER 77 MONOCYTOSIS AND MONOCYTOPENIA
Marshall A. Lichtman
CHAPTER 78 INFLAMMATORY AND MALIGNANT HISTIOCYTOSIS
Marshall A. Lichtman / Camille N. Abboud
CHAPTER 79 LIPID STORAGE DISEASES
Ernest Beutler
PART VIII
LYMPHOCYTES AND PLASMA CELLS
CHAPTER 80 MORPHOLOGY OF LYMPHOCYTES AND PLASMA CELLS
Stephen M. Baird
CHAPTER 81 COMPOSITION AND BIOCHEMISTRY OF LYMPHOCYTES AND PLASMA CELLS
Thomas J. Kipps / Dennis A. Carson
CHAPTER 82 LYMPHOCYTE ONTOGENY
Tucker W. LeBien / Fred E. Bertrand
CHAPTER 83 FUNCTIONS OF B LYMPHOCYTES AND PLASMA CELLS IN IMMUNOGLOBULIN PRODUCTION
Thomas J. Kipps
CHAPTER 84 FUNCTIONS OF T LYMPHOCYTES: T-CELL RECEPTORS FOR ANTIGEN
Thomas J. Kipps
CHAPTER 85 FUNCTIONS OF NATURAL KILLER CELLS
Giorgio Trinchieri / Lewis L. Lanier
CHAPTER 86 CLASSIFICATION AND CLINICAL MANIFESTATION OF LYMPHOCYTE AND PLASMA CELL DISORDERS
Thomas J. Kipps
CHAPTER 87 LYMPHOCYTOSIS AND LYMPHOCYTOPENIA
Thomas J. Kipps
CHAPTER 88 IMMUNODEFICIENCY DISEASES
Fred S. Rosen
CHAPTER 89 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
Howard A. Liebman / Timothy P. Cooley / Alexandra M. Levine
CHAPTER 90 MONONUCLEOSIS SYNDROMES
Kuo-Liang Huang / Robert F. Betts
PART IX
MALIGNANT DISEASES
CHAPTER 91 CLASSIFICATION AND CLINICAL MANIFESTATIONS OF THE CLONAL MYELOID DISORDERS
Marshall A. Lichtman
CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC
LEUKEMIA)
Marshall A. Lichtman / James K. Brennan
CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA
Marshall A. Lichtman / Jane L. Liesveld
CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS
Marshall A. Lichtman / Jane L. Liesveld
CHAPTER 95 IDIOPATHIC MYELOFIBROSIS (AGNOGENIC MYELOID METAPLASIA)
Marshall A. Lichtman
CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS
Thomas J. Kipps
CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA
Ching-Hon Piu
CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELATED DISEASES
Thomas J. Kipps
CHAPTER 99 HAIRY CELL LEUKEMIA
Alan Saven
CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA
Thomas P. Loughran / Marshall E. Kadin
CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS
Peter M. Banks
CHAPTER 102 HODGKIN LYMPHOMA
Sandra J. Horning
CHAPTER 103 LYMPHOMAS
Kenneth A. Foon / Richard I. Fisher
CHAPTER 104 PLASMA CELL NEOPLASMS: GENERAL CONSIDERATIONS
Stephen M. Baird
CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY
Marshall A. Lichtman
CHAPTER 106 PLASMA CELL MYELOMA
Bart Barlogie / John Shaughnessy / Nikhil Munshi / Joshua Epstein
CHAPTER 107 THE AMYLOIDOSIS
Joel N. Buxbaum / Daniel R. Jacobson
CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA
Thomas J. Kipps
CHAPTER 109 HEAVY-CHAIN DISEASES
Joel N. Buxbaum / Alice Alexander
PART X
HEMOSTASIS AND THROMBOSIS
CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS
David J. Kuter
CHAPTER 111 PLATELET MORPHOLOGY, BIOCHEMISTRY AND FUNCTION
Leslie V. Parise / Susan S. Smyth / Barry S. Coller
CHAPTER 112 MOLECULAR BIOLOGY AND BIOCHEMISTRY OF THE COAGULATION FACTORS AND PATHWAYS OF
HEMOSTASIS
Harold R. Roberts / Dougald M. Monroe III / Maureane Hoffman
CHAPTER 113 CONTROL OF COAGULATION REACTIONS
John H. Griffin
CHAPTER 114 VASCULAR FUNCTION IN HEMOSTASIS
Katherine A. Hajjar / Naomi L. Esmon / Aaron J. Marcus / William Muller
CHAPTER 115 CLASSIFICATION, CLINICAL MANIFESTATIONS AND EVALUATION OF DISORDERS OF HEMOSTASIS
Uri Seligsohn / Barry S. Coller
CHAPTER 116 MOLECULAR MECHANISMS OF FIBRINOLYSIS
Katherine A. Hajjar
CHAPTER 117 THROMBOCYTOPENIA
James N. George / Mujahid A. Rizvi
CHAPTER 118 THROMBOCYTOSIS AND ESSENTIAL THROMBOCYTHEMIA
Andrew I. Schafer
CHAPTER 119 HEREDITARY QUALITATIVE PLATELET DISORDERS
Barry S. Coller / Deborah L. French
CHAPTER 120 ACQUIRED QUALITATIVE PLATELET DISORDERS DUE TO DISEASES, DRUGS, AND FOODS
Sanford J. Shattil / Charles S. Abrams / Joel S. Bennett
CHAPTER 121 THE VASCULAR PURPURAS
Paul I. Schneiderman
CHAPTER 122 INHERITED DEFICIENCIES OF COAGULATION FACTORS II, V, VII, XI, AND XIII AND THE COMBINED
DEFICIENCIES OF FACTORS V AND VIII AND OF THE VITAMIN K-DEPENDENT FACTORS
Uri Seligsohn / Gilbert C. White, II
CHAPTER 123 HEMOPHILIA A AND HEMOPHILIA B
Harold R. Roberts / Maureane Hoffman
CHAPTER 124 HEREDITARY ABNORMALITIES OF FIBRINOGEN
Michael W. Mosesson
CHAPTER 125 HEMOSTATIC DYSFUNCTION RELATED TO LIVER DISEASES AND LIVER TRANSPLANTATION
Eberhard F. Mammen
CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION
Uri Seligsohn
CHAPTER 127 HEREDITARY THROMBOPHILIA
Scott H. Goodnight / John H. Griffin
CHAPTER 128 THE ANTIPHOSPHOLIPID SYNDROME
Jacob H. Rand
CHAPTER 129 VENOUS THROMBOSIS
Gary E. Raskob / Russell D. Hull / Graham F. Pineo
CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS, AND CORONARY ARTERY DISEASE
Mark B. Taubman
CHAPTER 131 ANTIPLATELET THERAPY
Harvey J. Weiss
CHAPTER 132 ORAL ANTICOAGULATION
Sam Schulman
CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS
Gary E. Raskob / Russell D. Hull / Graham F. Pineo
CHAPTER 134 FIBRINOLYTIC THERAPY
Joseph Loscalzo
CHAPTER 135 VON WILLEBRAND DISEASE
David Ginsburg
CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFIBRINOLYTIC AGENTS
Fedor Bachmann
PART XI
TRANSFUSION MEDICINE
CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES
Loni Calhoun / Lawrence D. Petz
CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS
Karen A. Sullivan / Thomas J. Kipps
CHAPTER 139 BLOOD PROCUREMENT AND SCREENING
Jeffrey McCullough
CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND WHOLE BLOOD
Ernest Beutler
CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS
Nicholas A. Bandarenko / Mark E. Brecher
CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS