Table Of ContentViral Heart Disease
Edited by H.-D. Bolte
With 119 Figures and 45 Tables
Springer-Verlag
Berlin Heidelberg New York Tokyo 1984
Professor Dr. Heinz-Dietrich Bolte
Ludwig-Maximilians-U niversWit M iinchen,
Klinikum GroI3hadem, Medizinische Klinik I,
MarchioninistraI3e 15,8000 Miinchen 70,
Federal Republic of Germany
ISBN-13: 978-3-540-13112-0 e-ISBN -13: 978-3-642-95448-1
DOl: 10.1007/978-3-642-95448-1
Library of Congress Cataloging in Publication Data. Main entry under title:
Viral heart disease. Bibliography: p. Includes index. 1. Virus diseases.
2. Heart-Diseases. 3. Heart-Infections. I. Bolte, H.-D. (Heinz-Dietrich), 1935 -
[DNLM: 1. Myocardial diseases. 2. Myocarditis. 3. Virus diseases. WG 280V813j
RC685.V57V57 1984 616.1'2 83-25388
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Preface
Since the last meeting "Myocardial Biopsy - Diagnostic Signifi
cance" was held under the auspices of the International Society and
Federation of Cardiology (ISFC) in Munich, many new data and
new aspects have been developed in the field of myocardial dis
eases. Most importantly, the classification of cardiomyopathies and
specific heart muscle diseases, as described in the report of the
WHO-ISFC task force (see reference 1 in the Introduction), is now
widely accepted as a basis for clinical practice and scientific work.
Investigators from all over the world have again assembled un
der the auspices of the ISFC at an international workshop on viral
heart disease and its implications with regard to congestive cardio
myopathy, which was held in Munich January 1983. This book con
tains the significant results of the workshop. For practical use, the
authors have incorporated important points made in the discussions
into their contributions and a subject index has been provided.
First of all I should like to thank Professor Riecker, Director of
the Medizinische Klinik, Klinikum Grol3hadern, University of Mu
nich, West Germany. Without his friendly support in many aspects,
this meeting would not have been possible. I should like to thank
Professor Goodwin and Dr. Olsen from the ISFC for their active
participation and advice in organizing the meeting. Last but not
least, I am particularely grateful to all the contributors, whose co
operation has made this book possible.
The generous financial support, including the expert secretarial
help by Mrs. B. Kratzenberg, given by Pharma Schwarz, Monheim,
West Germany, is gratefully acknowledged. In addition, I should
like to express my gratitude to Springer-Verlag, in particular to Dr.
Wieczorek who arranged for this edition in an experienced manner
and has taken into account the editor's special intentions.
Munich, March 1984 H.-D. Bolte
Contents
Introduction
H.-D. Bolte . 1
Chapter I: Histopathology and Virology
Histomorphological Relations Between Myocarditis and
Dilated Cardiomyopathy
E. G. J. Olsen . . . . . . . . . . . . . . . . . . . . . . . . . 5
Histopathological Aspects of Myocarditis with Special
Reference to Mumps, Cytomegalovirus Infection and the Role
of Endomyocardial Biopsy
U. Baandrup and S.A. Mortensen . . . . . . . . . . . . . . . .. 13
Relations Between Viral Infection of the Myocardium and the
Synthesis of Collagen Types I and III
S. Fischer, B. Ludwig, and H.-D. Bolte. . . . . . . . . . . 26
Electron Microscopic Demonstration of Viruses in the
Myocardium, with Particular Reference to Reovirus
G. Hubner. . . . . . . . . . . . . . . . . . . . . . . . . . . 31
Animal Models of Congestive Heart Failure and Congestive
(Dilated) Cardiomyopathy Due to Viral Myocarditis in Mice
A. Matsumori and C. Kawai . . . . . . . . . . . . . . . . . .. 35
Effect of Interferon on the Replication of Coxsackie B3 Virus
in Cultured Human Fetal Heart Cells
R. Kando/fa nd P. H. Hofschneider . . . . . . . . . . . . . . .. 57
The Role ofVirus-, and Immune-Mediated Cardiocyte Injury
in Coxsackievirus B3-Induced Myocarditis
S.A. Huber, P.A. Lodge, and L. P. Job. . . . . . . . . . . . . 64
Characterization of the Inflammatory Infiltrate in Human
Myocarditis - An Endomyocardial Biopsy Study
C. C. Marboe, D. M. Knowles, M. B. Weiss, P. C. Ursell,
and J. J. Fenoglio, Jr. . . . . . . . . . . . . . . . . . . . . . . .. 74
VIII Contents
The Role of Eosinophils in Myocarditis
C. J. F. Spry, P.-c. Tai, J. Davies, E. G. J. Olsen,
and J. F. Goodwin. . . . . . . . . . . . . . . . . . . . . . . . .. 83
Chapter II : Clinical Virology and Cellular Immunology
Coxsackie B Virus-Specific IgM Responses in Patients with
Cardiac and Other Diseases
D.J. Coltart, M.M. O.EI-Hagrassy, andJ.E.Banatvala . . 89
Viral Heart Disease - A Precursor of Congestive
Cardiomyopathy
C.L.Miklozek, P. C. Come, H. D. Royal, C.S. Crumpacker,
and W.H.Abelmann ........................ 95
Virus Investigations in Heart Muscle Disease
p. Morgan-Capner, P. J. Richardson, C. McSorley, K. Daly,
and J. R. Pattison . . . . . . . . . . . . . . . . . . . . . . . 99
Experience with Enzyme-Linked Immunosorbent Assay for the
Detection of Antibodies of the IgM Class Against Coxsackie B
Viruses
M. Roggendorf . . . . . . . . . . . . . . . . . . . . . . . . . . . 116
Cardiocytolysis by Sera of Patients Suffering from Acute
Perimyocarditis
B. Maisch . . . . . . . . . . . . . . . . . . . . . . . . . . . ... 121
Autoantibodies Against the Adenine Nucleotide Translocator
in Myocarditis and Dilated Cardiomyopathy
H."P' SchultheifJ, H.-D. Bolte, and P. Schwimmbeck . ....... 131
Dilated Cardiomyopathy: A Consequence of Defective
Suppressor Cell Function?
R.E.Fowles. . . . . . . . . . . . . . . . . . . . . . . . . . 144
The Role of Human Leukocyte Antigen Genes and Low
Suppressor Cell Activity in the Pathogenesis of Myocarditis
and Dilated Cardiomyopathy
R.Eckstein, W.Mempel, M.Heim, and H.-D. Bolte ........ 150
Chapter III: Haemodynamics and Therapeutic Aspects
Haemodynamic Findings in Biopsy Proven Acute Myocarditis
p. J. Richardson, K. Daly, and P. Gishen .............. 165
Endomyocardial Biopsy: Technique and Evaluation of a New
Disposable Forceps and Catheter Sheath System
P. J. Richardson. . . . . . . . . . . . . . . . . . . . . . . . . . . 173
Contents IX
Viral Myocarditis: Symptomatology, Clinical Diagnostics and
Haemodynamics
H.-D. Bolte and B. Ludwig . . . . . . . . . . . . . . . . . . . . . 177
Potential Value of Colour-Coded Two-Dimensional
Echocardiograms in the Study of Inflammatory Left
Ventricular Disease
D. G. Gibson ....................... . 187
Assessment of Left Ventricular Reserve Using Radionuclide
Ventriculography in Patients with Prior Myocarditis
S. K. Das, H. T. Colfer, and B. Pitt . . . . . . . . . . . . . . 193
Endomyocardial Biopsy Diagnosis of Myocarditis and
Changes Following Immunsuppressive Treatment
M. E. Billingham and J. W. Mason. . . . . . . . . . . . . 200
Do Tetrapeptides Playa Role in Viral Heart Disease?
Y. Becker . . . . . . . . . . . . . . . . . . . . . . . . . . 211
Relations Between Virus Infections and Coronary Artery
Disease
M. Thomas, N. Slocum, and A. C. Nicholls ............ 217
Therapeutic Aspects in Myocardial Diseases
F. Waagstein . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Summary of Workshop
J. F. Goodwin . . . . . . . . . . . . . . . . . . . . . . . . . . . . 234
Subject Index ............................ 241
List of Contributors
Abelmann, W. H., Prof. Dr.
Beth Israel Hospital, Department of Medicine, Harvard Medical
School, Boston, MA 02215, USA
Baandrup, u., M. D.
University Institute of Pathology, The Municipal Hospital,
8000 Aarhus C, Denmark
Banatvala, J. E., M. D.
Department of Virology, St. Thomas's Hospital and Medical School,
London SE1 7EH, United Kingdom
Becker, Y., Prof. Dr.
Department of Molecular Virology, Faculty of Medicine,
The Hebrew University, Jerusalem, Israel
Billingham, M. E., M. D., Prof., Dr.
Department of Pathology, Stanford University Medical Center,
300 Pasteur Drive, Stanford, CA 94305, USA
Bolte, H.-D., Prof., Dr.
Ludwig-Maximilians-Universitat Miinchen, Klinikum GroBhadern,
Medizinische Klinik I, MarchioninistraBe 15, 8000 Miinchen 70,
Federal Republic of Germany
Colfer, H. T., M. D.
Division of Cardiology, University of Michigan Medical Center,
Ann Arbor, MI 48109, USA
Coltart, D.J., M.D.
Cardiac Department, St. Thomas's Hospital, London SE1 7EH,
United Kingdom
c.,
Come, P. M. D.
Beth Israel Hospital, Department of Medicine, Harvard Medical
School, Boston, MA 02215, USA
Crumpacker, C. S., M. D.
Beth Israel Hospital, Department of Medicine, Harvard Medical
School, Boston, MA 02215, USA
XII List of Contributors
Daly, K., M. D.
Department of Cardiology, King's College Hospital Medical
School, Denmark Hill, London SE5 9RS, United Kingdom
Das, S. K., M. D., Prof., Dr.
Division of Cardiology, University of Michigan Medical Center,
Ann Arbor, MI 48109, USA
Davies, J., M. D.
Royal Postgraduate School, Hammersmith Hospital, 150 DuCane
Road, London W12 OHS, United Kingdom
Eckstein, R., Dr.
Ludwig-Maximilians-Universitat Munchen, Klinikum Grol3hadern,
Medizinische Klinik III, Marchioninistral3e 15, 8000 Munchen 70,
Federal Republic of Germany
Eggers, H.J., Prof. Dr.
Institut fUr Virologie, Universitat Koln, Furst-Piickler Stral3e 56,
5000 Koln 41, Federal Republic of Germany
El-Hagrassy, M.M.O., M.D.
Department of Virology, St. Thomas's Hospital and Medical School,
London SE1 7EH, United Kingdom
Fenoglio, Jr., J. J., M. D.
Department of Pathology, Columbia University College of
Physicians and Surgeons, 630 West 168th Street, New York,
NY 10032, USA
Fischer, S., Dr.
Ludwig-Maximilians-Universitat Munchen, Klinikum Grol3hadern,
Medizinische Klinik I, Marchioninistral3e 15, 8000 Munchen 70,
Federal Republic of Germany
Fowles, R. E., M. D., Prof. Dr.
Cardiology Division, Stanford University School of Medicine,
Stanford, CA 94305, USA
Gibson, D. G., M. D.
Cardiac Department, Brompton Hospital, Fulham Road, London
SE3 6HP, United Kingdom
Gishen, P., M. D.
Department of Radiology, King's College Hospital Medical School,
Denmark Hill, London SE5 9RS, United Kingdom
Goodwin, J. F., M. D., Prof., Dr.
Royal Postgraduate Medical School, Hammersmith Hospital,
150 DuCane Road, London W12 OHS, United Kingdom
List of Contributors XIII
Heim, M., cando med.
BSD-BRK Transfusionszentrum, Blutdepot,
Ludwig-Maximilians-UniversiHit Miinchen, Klinikum Grol3hadern,
Medizinische Klinik III, Marchioninistral3e 15,8000 Miinchen 70,
Federal Republic of Germany
Hofschneider, P. H., Prof., Dr. Dr.
Max-Planck-Institut fUr Biochemie, 8033 Martinsried, Federal
Republic of Germany
Huber, S. A., M. D., Prof., Dr.
Department of Pathology, University of Vermont, Burlington,
VT 05405, USA
Hiibner, G., Prof., Dr.
Pathologisches Institut der Universitat Miinchen, Thalkirchner
Stral3e 36, 8000 Miinchen 2, Federal Republic of Germany
Job, L. P., M. D.
Department of Pathology, University of Vermont, Burlington,
VT 05405, USA
Kandolf, R., Dr.
Max-Planck-Institut fUr Biochemie, 8033 Martinsried, Federal
Republic of Germany
Kawai, C, M. D., Prof. Dr.
The Third Division, Department of Internal Medicine, Faculty of
Medicine, Kyoto University, Kyoto, Japan
Knowles, D. M., M. D.
Department of Pathology, New York University Medical Center,
New York, NY 10016, USA
Lodge, P.A., M.D.
Department of Pathology, University of Vermont, Burlington,
VT 05405, USA
Ludwig, B., Dr.
Ludwig-Maximilians-U niversitat Miinchen, Klinikum Grol3hadern,
Medizinische Klinik I, Marchioninistral3e 15, 8000 Miinchen 70,
Federal Republic of Germany
Maisch, B., Priv.-Doz., Dr.
Medizinische Klinik der Universitat Wiirzburg,
Josef-Schneider-Stral3e 2, 8700 Wiirzburg, Federal Republic of
Germany
Marboe, C C, M. D.
Department of Pathology, Columbia University College of
Physicians and Surgeons, 630 West 168th Street, New York,
NY 10032, USA
