Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272

298 Pages·2006·7.82 MB·English

by  Novartis Foundation(eds.)

Signalling Pathways in Acute Oxygen Sensing: Novartis Foundation Symposium 272, Volume 272.
Edited by Derek J. Chadwick and Jamie Goode
Copyright  Novartis Foundation 2006. ISBN: 0-470-01457-1
SIGNALLING PATHWAYS IN
ACUTE OXYGEN SENSING
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Novartis Foundation Symposium 272
SIGNALLING
PATHWAYS IN
ACUTE OXYGEN
SENSING
2006
Copyright © Novartis Foundation 2006
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Novartis Foundation Symposium 272
xii +288 pages,56 figures,2 tables
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ISBN-10 0-470-01457-1
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Contents
Symposium on Signalling pathways in acute oxygen sensing, held at the Novartis Foundation,
London, 25–27 January 2005
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium is based on a proposal made by Jeremy Ward
Michael Duchen Chair’s introduction 1
Gregg L.Semenza,Larissa A.Shimodaand Nanduri R.Prabhakar
Regulation of gene expression by HIF-1 2
Discussion 8
Ineke P.Stolze,David R.Moleand Peter J.Ratcliffe Regulation of HIF:
prolyl hydroxylases 15
Discussion 25
General discussion I 33
Daniel Peetand Sarah Linke Regulation of HIF:asparaginyl
hydroxylation 37
Discussion 49
José López-Barneo,Patricia Ortega-Sáenz,José I.Piruat and
María García-Fernández Oxygen-sensing by ion channels and
mitochondrial function in carotid body glomus cells 54
Discussion 64
Keith J.Buckler,Beatrice A.Williams,Rodrigo Varas Orozcoand
Christopher N.Wyatt The role of TASK-like K+channels in oxygen
sensing in the carotid body 73
Discussion 85
v
vi CONTENTS
Nanduri R.Prabhakar,Ying-Jie Peng,Guoxiang Yuanand
Ganesh K.Kumar Reactive oxygen species facilitate oxygen
sensing 95
Discussion 100
C.A.Nurse,J.Buttigieg,R.Thompson,M.Zhangand E.Cutz
Oxygen sensing in neuroepithelial and adrenal chromaffin cells 106
Discussion 114
C.Peers,P.Kang,J.P.Boyle,K.E.Porter,H.A.Pearson,I.F.Smith
andP.J.Kemp Hypoxic regulation of Ca2+signalling in astrocytes and
endothelial cells 119
Discussion 127
General discussion II 131
Paul J.Kemp,Sandile E.J.Williams,Helen S.Mason,Phillippa Wootton,
David E.Iles,Daniela Riccardiand Chris Peers Functional proteomics
of BK potassium channels:defining the acute oxygen sensor 141
Discussion 151
Stephen L.Archer,Evangelos D.Michelakis,Bernard Thébaud,
Sebastien Bonnet,Rohit Moudgil,Xi-Chen WuandE.Kenneth Weir
A central role for oxygen-sensitive K+channels and mitochondria in the
specialized oxygen-sensing system 157
Discussion 171
Gregory B.Waypaand Paul T.Schumacker Role for mitochondrial reactive
oxygen species in hypoxic pulmonary vasoconstriction 176
Discussion 192
Norbert Weissmann,Ralph T.Schermuly,Hossein A.Ghofrani,
Jörg Hänze,Parag Goyal,Friedrich Grimmingerand Werner Seeger
Hypoxic pulmonary vasoconstriction—triggered by an increase in reactive
oxygen species? 196
Discussion 208
General discussion III 214
Alison M.Gurneyand Shreena Joshi The role of twin pore domain and
other K+channels in hypoxic pulmonary vasoconstriction 218
Discussion 228
CONTENTS vii
A.Mark Evans,D.Grahame Hardie,Antony Galione,Chris Peers,
Prem Kumarand Christopher N.Wyatt AMP-activated protein kinase
couples mitochondrial inhibition by hypoxia to cell-specific Ca2+signalling
mechanisms in oxygen-sensing cells 234
Discussion 252
Silke Becker,Gregory A.Knock,Vladimir Snetkov,Jeremy P.T.Ward
and Philip I.Aaronson Role of capacitative Ca2+entry but not Na+/Ca2+
exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary
arteries 259
Discussion 268
Final general discussion 274
Index of contributors 280
Subject index 282
Participants
Philip I.Aaronson Department of Asthma,Allergy and Respiratory Science,
5th Floor,Thomas Guy House,Guy’s Hospital Campus,London SE1 9RT,
UK
Helmut Acker Cellvis,Harkordstr 92,Dortmund,D-44225,Germany
Stephen L.Archer Cardiology Division,University of Alberta,WMC 2C2.36,
8440 112th St,Edmonton,Alberta,T6G 2B7,Canada
Keith J.Buckler University Laboratory of Physiology,University of Oxford,
Oxford OX1 3PT,UK
Navdeep S.Chandel Division of Pulmonary and Critical Care Medicine,
Department of Medicine,Northwestern University Medical School,McGaw
2–2334,240 East Huron Avenue,Chicago,IL 60611-2909,USA
Michael Duchen(Chair) Department of Physiology,University College
London,Gower Street,London WC1E 6BT,UK
A.Mark Evans School of Biology,University of St Andrews,Bute Medical
Buildings,St Andrews,Fife KY16 9TS,UK
Constancio Gonzalez Departamento de Bioquimica y Biologia Molecular &
Fisiologia,Facultad de Medicina,Instituto de Biologia y Genetica Molecular,
Universidad de Valladolid y CSIC,Valladolid 47005,Spain
Alison Gurney Department of Physiology and Pharmacology,Strathclyde
Institute for Biomedical Sciences,University of Strathclyde,Glasgow G4 0NR,
UK
Adrian L.Harris Cancer Research UK Oxford Cancer Centre,Medical
Oncology Unit,Churchill Hospital,Headington,Oxford OX3 7LJ,UK
Paul J.Kemp School of Biosciences,University of Cardiff,P O Box 911,
Museum Avenue,Cardiff CF1 3US,UK
ix
x PARTICIPANTS
Prem Kumar Department of Physiology,The Medical School,University of
Birmingham,Birmingham B15 2TT,UK
Wolfgang Kummer Institute of Anatomy and Cell Biology,Justus-Liebig-
University,Aulweg 123,35385,Giessen,Germany
José López-Barneo Laboratorio de Investigaciones Biomedicas,Edificio de
Laboratorios,2 planta,Hospital Universitario Virgen del Rocio,Avda Manuel
Siurot s/n,Sevilla 41013,Spain
Michael P.Murphy MRC Dunn Human Nutrition Unit,Wellcome
Trust/MRC Building,Hills Road,Cambridge CB2 2XY,UK
Colin A.Nurse Department of Biology,McMaster University,1280 Main
Street West,Hamilton,Ontario,L8S 4KI,Canada
Chris Peers School of Medicine,University of Leeds,Leeds LS2 9JT,UK
Daniel Peet School of Molecular and Biomedical Science and ARC Special
Research Centre for Molecular Genetics of Development,The University of
Adelaide,Adelaide,SA 5005,Australia
Jacques Pouysségur Institute of Signaling,Developmental Biology and
Cancer Research,CNRS UMR 6543,Centre Antoine Lacassagne,33 Avenue
Valombrose,Nice 06189,France
Nanduri Prabhakar Department of Physiology and Biophysics,Case Western
Reserve University,10900 Euclid Avenue,Cleveland,OH 44106,USA
Peter J.Ratcliffe Nuffield Department of Medicine,NDM offices,level 7,
John Radcliffe Hospital,Oxford OX3 9DU,UK
Peter R.Rich Department of Biology,University College London,Gower
Street,London WC1E 6BT,UK
Paul T.Schumacker Department of Pediatrics,Division of Neonatology,
Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,
USA
Gregg L.Semenza Institute for Cell Engineering,Departments of Pediatrics,
Medicine,Oncology,Radiation Oncology and Institute of Genetic Medicine,
PARTICIPANTS xi
The Johns Hopkins University School of Medicine,Broadway Research
Building,Suite 671,733 North Broadway,Baltimore,MD 21205,USA
Ineke P.Stolze The Henry Wellcome Bulding for Molecular Physiology,
Roosevelt Drive,Oxford,OX3 7BN,UK
James T.Sylvester Division of Pulmonary and Critical Care Medicine,The
John’s Hopkins Asthma and Allergy Center,Baltimore,MD 21224,USA
Rodrigo Varas Orozco(Novartis Foundation Bursar) University Laboratory of
Physiology,Parks Rd,Oxford OX1 3PT,UK
Jeremy P.T.Ward Department of Asthma,Allergy and Respiratory Science,
c/o Cardiovascular Medicine & Biology,2nd Floor,New Hunt’s House,King’s
College London,Guy’s Hospital Campus,London SE1 1UL,UK
Kenneth Weir Department of Medicine and Physiology,V A Medical Center,
University of Minnesota,1 Veteran’s Drive,111C,Minneapolis,MN 55417,
USA
Norbert Weissmann Department of Internal Medicine,Justus-Liebig-
University,Klinikstr 36,35392 Giessen,Germany
John Westwick Novartis Institutes for Biomedical Research Wimblehurst Rd,
Horsham,West Sussex RH12 5A6,UK