Table Of ContentProgress in Inflammation Research
Series Editor
Prof. Michael J. Parnham PhD
Senior Scientific Advisor
PLIVA Research Institute Ltd.
Prilaz baruna Filipovic´a 29
HR-10000 Zagreb
Croatia
Advisory Board
G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA)
M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a.d. Riss, Germany)
W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles:
NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer,
G.Z. Feuerstein, Z. Zukowska (Editors), 2005
Turning up the Heat on Pain: Vanilloid Receptors in Pain and Inflammation,
A.B Malmberg, K.R. Bley (Editors), 2005
Sodium Channels, Pain, and Analgesia, K. Coward, M. Baker (Editors), 2005
Complement and Kidney Disease, P.F. Zipfel (Editor), 2005
(Already published titles see last page.)
Regulatory T Cells in Inflammation
Leonie S. Taams
Arne N. Akbar
Marca H. M. Wauben
Editors
Birkhäuser Verlag
Basel · Boston · Berlin
Editors
Leonie S. Taams Arne N. Akbar
Infection & Immunity Research Group Department of Immunology and Molecular Pathology
Franklin-Wilkins Building Division of Infection and Immunity
King's College London University College London
150 Stamford Street 46 Cleveland Street
London SE1 9NN London W1T 4JF
UK UK
Marca H. M. Wauben
Department of Immunohematology and
Blood Transfusion
E3-Q, Leiden University Medical Center
Albinusdreef 2, P.O. Box 9600
2300 RC Leiden
The Netherlands
Library of Congress Cataloging-in-Publication Data
Regulatory T cells in inflammation / Leonie Taams, Arne N. Akbar, Marca H.M. Wauben, editors.
p. ; cm. -- (Progress in inflammation research)
Includes bibliographical references and index.
ISBN 3-7643-7088-2 (alk. paper)
1. Inflammation. 2. T cells. I. Taams, Leonie. II. Akbar, Arne N. III. Wauben, Marca H. M. IV. PIR (Series)
[DNLM: 1. T-Lymphocytes--immunology. 2. Immunity, Cellular. 3. Immunotherapy--methods. QW 568 R3439 2005]
RB131.R44 2005
616’.0473--dc22
2004062666
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ISBN-10: 3-7643-7088-2 Birkhäuser Verlag, Basel – Boston – Berlin
ISBN-13: 978-3-7643-7088-6 Birkhäuser Verlag, Basel – Boston – Berlin
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Cover illustration: Cross-talk between antigen presenting cell and regulatory T cell. (By: E.N.M. Nolte’-t Hoen and
M.H.M. Wauben)
Printed in Germany
ISBN-10: 3-7643-7088-2
ISBN-13: 978-3-7643-7088-6
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Contents
List of contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi
Part I: Origin, function and distribution of regulatory T cells . . . . . . . . . . . . . . . . . . . 1
Shimon Sakaguchi and Noriko Sakaguchi
History of CD25+CD4+ regulatory T cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Dirk Homann and Matthias G. von Herrath
“Natural” and “induced” regulatory T cells – purpose and problems
associated with an emerging distinction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Robert N. Barker and Frank J. Ward
The role of interleukin-10 in regulatory-T-cell suppression: reconciling
the discrepancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Esther N. M. Nolte-‘t Hoen and Marca H. M. Wauben
Activation and distribution of regulatory T cells in naïve and
antigen-stimulated immune systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Kevin J. Maloy and Fiona Powrie
Regulatory T cells and the innate immune system . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Part II: The potential use of regulatory T cells in immunotherapy. . . . . . . . . . . . . . . 93
Nadia Giarratana, Giuseppe Penna, Silvia Gregori, Kenn C. Daniel
and Luciano Adorini
Exploiting the potential of regulatory T cells in the control of
type 1 diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
Sophie Candon and Lucienne Chatenoud
Regulatory T cells in type 1 autoimmune diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
Clare Baecher-Allan, Vissia Viglietta and David A. Hafler
The potential for targeting CD4+CD25+ regulatory T cells in the
treatment of multiple sclerosis in humans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
Jocea M. van Amelsfort, Johannes W. J. Bijlsma and Leonie S. Taams
Immunotherapy of rheumatoid arthritis using CD4+CD25+
regulatory T cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153
Douglas S. Robinson and Eleanor M. Ling
Potential for manipulation of regulatory T cells in treatment or
prevention of allergic disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
Katie E. Birch, Milica Vukmanovic-Stejic, John R. Reed,
Malcolm H. A. Rustin and Arne N. Akbar
The role of regulatory T cells in cutaneous disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Kathryn J. Wood and Ahmed Akl
The potential role of CD25+CD4+ regulatory T cells in the induction
and maintenance of transplantation tolerance in humans . . . . . . . . . . . . . . . . . . . . . . . 221
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237
List of contributors
Luciano Adorini, BioXell, Via Olgettina 58, 20132 Milano, Italy;
e-mail: [email protected]
Arne N. Akbar, Department of Immunology and Molecular Pathology, Division of
Infection and Immunity, University College London, 46 Cleveland Street, London
W1T 4JF, UK; e-mail: [email protected]
Ahmed Akl, Nuffield Department of Surgery, John Radcliffe Hospital, University of
Oxford, Oxford OX3 9DU, United Kingdom; e-mail: [email protected]
Clare Baecher-Allan, Laboratory of Molecular Immunology, Center for Neurologic
Diseases, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue
Louis Pasteur, Boston, MA 02115, USA; e-mail: [email protected]
Robert N. Barker, Department of Medicine and Therapeutics, Institute of Medical
Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK;
e-mail: [email protected]
Johannes W. J. Bijlsma, Dept Rheumatology & Clinical Immunology, University
Medical Center Utrecht, 3508 GA Utrecht, the Netherlands;
e-mail: [email protected]
Katie E. Birch, Department of Immunology and Molecular Pathology, Division of
Infection and Immunity, University College London, 46 Cleveland Street, London
W1T 4JF, UK; and Department of Dermatology, Royal Free Hospital, Pond Street,
London NW3 2QG, UK; e-mail: [email protected]
Sophie Candon, INSERM U580, Hôpital Necker, 161 Rue de Sèvres, 75743 Paris
Cedex 15, France; e-mail: [email protected]
vii
List of contributors
Lucienne Chatenoud, INSERM U580, Hôpital Necker, 161 Rue de Sèvres, 75743
Paris Cedex 15, France; e-mail: [email protected]
Kenn C. Daniel, BioXell, Via Olgettina 58, 20132 Milano, Italy;
e-mail: [email protected]
Nadia Giarratana, BioXell, Via Olgettina 58, 20132 Milano, Italy;
e-mail: [email protected]
Silvia Gregori, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Via
Olgettina 58, 20132 Milano, Italy; e-mail: [email protected]
David A. Hafler, Laboratory of Molecular Immunology, Center for Neurologic Dis-
eases, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue
Louis Pasteur, Boston, MA 02115, USA; e-mail: [email protected]
Dirk Homann, University of Colorado Health Sciences Center, Barbara Davis Cen-
ter for Childhood Diabetes, 4200 East 9th Avenue, Box 140, Denver, CO 80262,
USA; e-mail: [email protected]
Eleanor M. Ling, Leukocyte Biology Section, Division of Biomedical Sciences and
Allergy and Clinical Immunology, National Heart and Lung Institute, Sir Alexander
Fleming Building, Imperial College London, Exhibition Road, London SW7 2AZ,
UK
Kevin J. Maloy, Sir William Dunn School of Pathology, University of Oxford, South
Parks Road, Oxford, OX1 3RE, UK; e-mail: [email protected]
Esther N. M. Nolte-’t Hoen, Faculty of Biological Sciences, Imperial College Lon-
don, South Kensington Campus, London SW7 2AZ, UK;
e-mail: [email protected]
Giuseppe Penna, BioXell, Via Olgettina 58, 20132 Milano, Italy;
e-mail: [email protected]
Fiona Powrie, Sir William Dunn School of Pathology, University of Oxford, South
Parks Road, Oxford, OX1 3RE, UK; e-mail: [email protected]
John R. Reed, Department of Immunology and Molecular Pathology, Division of
Infection and Immunity, University College London, 46 Cleveland Street, London
W1T 4JF, UK; e-mail: [email protected]
viii
List of contributors
Douglas S. Robinson, Leukocyte Biology Section, Division of Biomedical Sciences
and Allergy and Clinical Immunology, National Heart and Lung Institute, Sir
Alexander Fleming Building, Imperial College London, Exhibition Road, London
SW7 2AZ, UK; e-mail: [email protected]
Malcolm H.A. Rustin, Department of Dermatology, Royal Free Hospital, Pond
Street, London NW3 2QG, UK
Noriko Sakaguchi, Department of Experimental Pathology, Institute for Frontier
Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; and Laboratory of
Immunopathology, Research Center for Allergy and Immunology, The Institute for
Physical and Chemical Research (RIKEN), Yokohama 230-0045, Japan;
e-mail: [email protected]
Shimon Sakaguchi, Department of Experimental Pathology, Institute for Frontier
Medical Sciences, Kyoto University, 53 Shogoin Kawahara-cho, Sakyo-ku, Kyoto
606-8507, Japan; and Laboratory of Immunopathology, Research Center for Aller-
gy and Immunology, The Institute for Physical and Chemical Research (RIKEN),
Yokohama 230-0045, Japan; and Core Research for Evolutional Science and Tech-
nology (CREST), Science and Technology Agency of Japan, Kawaguchi 332-0012,
Japan; e-mail: [email protected]
Leonie S. Taams, Infection & Immunity Research Group, Franklin-Wilkins Build-
ing, King’s College London, 150 Stamford Street, London SE1 9NN, UK;
e-mail: [email protected]
Jocea M. van Amelsfort, Dept Rheumatology & Clinical Immunology, University
Medical Center Utrecht, 3508 GA Utrecht, the Netherlands;
e-mail: [email protected]
Vissia Viglietta, Laboratory of Molecular Immunology, Center for Neurologic Dis-
eases, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue
Louis Pasteur, Boston, MA 02115, USA; e-mail: [email protected]
Matthias G. von Herrath, La Jolla Institute for Allergy and Immunology, Division
of Immune Regulation, 10355 Science Center Drive, La Jolla, San Diego, CA 92121,
USA; e-mail: [email protected]
Milica Vukmanovic-Stejic, Department of Immunology and Molecular Pathology,
Division of Infection and Immunity, University College London, 46 Cleveland
Street, London W1T 4JF, UK; e-mail: [email protected]
ix
List of contributors
Frank J. Ward, Department of Medicine and Therapeutics, Institute of Medical Sci-
ences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK;
e-mail: [email protected]
Marca H. M. Wauben, Department of Immunohematology and Blood Transfusion,
E3-Q, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC
Leiden, The Netherlands; e-mail: [email protected]
Kathryn J. Wood, Nuffield Department of Surgery, John Radcliffe Hospital, Uni-
versity of Oxford, Oxford OX3 9DU, United Kingdom;
e-mail: [email protected]
x
Description:Scientific interest in regulatory T cells has revived during the last decade. Initially described in the early seventies as suppressor T cells, the concept of suppressor/regulatory T cells went through turbulent times during the eighties when molecular analysis failed to identify putative suppressor
