PI: Andersen, Julie Kay Title: 2011 Oxidative Stress and Disease

32 Pages·2010·0.14 MB·English

PI: Andersen, Julie Kay Title: 2011 Oxidative Stress and Disease Gordon Research Conference
Received: 03/12/2010 FOA: PA10-071 Council: 10/2010
Competition ID: ADOBE-FORMS-B FOA Title: NIH Support for Conferences and Scientific Meetings (Parent R13/U13)
1 R13 AG039062-01 Dual: GM,NS Accession Number: 3281310
IPF: 2988701 Organization: GORDON RESEARCH CONFERENCES
Former Number: Department:
IRG/SRG: NIA-B AIDS: N Expedited: N
Subtotal Direct Costs Animals: N New Investigator: N
(excludes consortium F&A) Humans: N Early Stage Investigator: N
Year 1: 70,000 Clinical Trial: N
Current HS Code: 10
HESC: N

Senior/Key Personnel: Organization: Role Category:
Julie Andersen Ph.D. Buck Institute for Age Research PD/PI
OMB Number: 4040-0001
Expiration Date: 06/30/2011
APPLICATION FOR FEDERAL ASSISTANCE
3. DATE RECEIVED BY STATE State Application Identifier
SF 424 (R&R)
1. * TYPE OF SUBMISSION 4. a. Federal Identifier GRANT10556416
Pre-application Application Changed/Corrected Application
b. Agency Routing Identifier
2. DATE SUBMITTED Applicant Identifier
5. APPLICANT INFORMATION * Organizational DUNS: 075712877
* Legal Name: Gordon Research Conferences
Department: Division:
* Street1: 512 Liberty Lane
Street2:
* City: West Kingston County / Parish: Washington
* State: RI: Rhode Island Province:
* Country: USA: UNITED STATES * ZIP / Postal Code: 02892-1502
Person to be contacted on matters involving this application
Prefix: * First Name: Taryn Middle Name:
* Last Name: Groves Suffix:
* Phone Number: 401-360-1517 Fax Number: 401-783-7644
Email: [email protected]
6. * EMPLOYER IDENTIFICATION (EIN) or (TIN): 1050300582A1
7. * TYPE OF APPLICANT: M: Nonprofit with 501C3 IRS Status (Other than Institution of Higher Education)
Other (Specify):
Small Business Organization Type Women Owned Socially and Economically Disadvantaged
8. * TYPE OF APPLICATION: If Revision, mark appropriate box(es).
New Resubmission A. Increase Award B. Decrease Award C. Increase Duration D. Decrease Duration
Renewal Continuation Revision E. Other (specify):
* Is this application being submitted to other agencies? Yes No What other Agencies?
9. * NAME OF FEDERAL AGENCY: 10. CATALOG OF FEDERAL DOMESTIC ASSISTANCE NUMBER:
National Institutes of Health TITLE:
11. * DESCRIPTIVE TITLE OF APPLICANT'S PROJECT:
2011 Oxidative Stress and Disease Gordon Research Conference
12. PROPOSED PROJECT: * 13. CONGRESSIONAL DISTRICT OF APPLICANT
* Start Date * Ending Date
01/11/2011 05/18/2011 RI-002
14. PROJECT DIRECTOR/PRINCIPAL INVESTIGATOR CONTACT INFORMATION
Prefix: Dr. * First Name: Julie Middle Name: Kay
* Last Name: Andersen Suffix: Ph.D.
Position/Title: Professor
* Organization Name: Buck Institute for Age Research
Department: Division:
* Street1: 8001 Redwood Blvd.
Street2:
* City: Novato County / Parish: Marin
* State: CA: California Province:
* Country: USA: UNITED STATES * ZIP / Postal Code: 94945-1400
* Phone Number: 415-209-2070 Fax Number: 415-209-2231
* Email: [email protected]
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SF 424 (R&R) Page 2
APPLICATION FOR FEDERAL ASSISTANCE
15. ESTIMATED PROJECT FUNDING 16. * IS APPLICATION SUBJECT TO REVIEW BY STATE EXECUTIVE
ORDER 12372 PROCESS?
a. YES THIS PREAPP LICATION/APPLICATION WAS MADE
a. Total Federal Funds Requested 70,000.00 AVAILABLE TO THE STATE EXECUTIVE ORDER 12372
b. Total Non-Federal Funds 0.00 PROCESS FOR REVIEW ON:
DATE:
c. Total Federal & Non-Federal Funds 70,000.00
b. NO PROGRAM IS NOT COVERED BY E.O. 12372; OR
d. Estimated Program Income 0.00
PROGRAM HA S NOT BEEN SELECTED BY STATE FOR
REVIEW
17. By signing this application, I certify (1) to the statements contained in the list of certifications* and (2) that the statements herein are
true, complete and accurate to the best of my knowledge. I also provide the required assurances * and agree to comply with any resulting
terms if I accept an award. I am aware that any false, fictitious. or fraudulent statements or claims may subject me to criminal, civil, or
administrative penalities. (U.S. Code, Title 18, Section 1001)
* I agree
* The list of certifications and assurances, or an Internet site where you may obtain this list, is contained in the announcement or agency specific instructions.
18. SFLLL or other Explanatory Documentation
Add Attachment Delete Attachment View Attachment
19. Authorized Representative
Prefix: * First Name: Nancy Middle Name:
* Last Name: Ryan Gray Suffix: Ph.D.
* Position/Title:Director
* Organization: Gordon Research Conferences
Department: Division:
* Street1: 512 Liberty Lane
Street2:
* City: West Kingston County / Parish: Washington
* State: RI: Rhode Island Province:
* Country: USA: UNITED STATES * ZIP / Postal Code: 02892-1502
* Phone Number: 401-360-1517 Fax Number: 401-783-7644
* Email: [email protected]
* Signature of Authorized Representative * Date Signed
Nancy Ryan Gray 03/12/2010
20. Pre-application Add Attachment Delete Attachment View Attachment
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Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
424 R&R and PHS-398 Specific
Page Numbers
Table Of Contents
SF 424 R&R Face Page------------------------------------------------------------------------------------------ 1
Table of Contents--------------------------------------------------------------------------------------------- 3
Performance Sites--------------------------------------------------------------------------------------------- 4
Research & Related Other Project Information------------------------------------------------------------------ 5
Project Summary/Abstract (Description)---------------------------------------- 6
Public Health Relevance Statement (Narrative attachment)---------------------------------------- 7
Facilities & Other Resources---------------------------------------- 8
Research & Related Senior/Key Person-------------------------------------------------------------------------- 9
Biographical Sketches for each listed Senior/Key Person---------------------------------------- 10
Research & Related Budget - Year 1---------------------------------------------------------------------------- 14
Budget Justification---------------------------------------- 17
Research & Related Budget - Cumulative Budget----------------------------------------------------------------- 19
PHS 398 Specific Cover Page Supplement------------------------------------------------------------------------ 20
PHS 398 Specific Research Plan-------------------------------------------------------------------------------- 22
Specific Aims---------------------------------------- 23
Research Strategy---------------------------------------- 24
PHS 398 Checklist--------------------------------------------------------------------------------------------- 30
Table of Contents Page 3
Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
OMB Number: 4040-0010
Expiration Date: 08/31/2011
Project/Performance Site Location(s)
I am submitting an application as an individual, and not on behalf of a company, state,
Project/Performance Site Primary Location
local or tribal government, academia, or other type of organization.
Organization Name: Gordon Research conferences
DUNS Number: 0727128770000
* Street1: 512 Liberty Lane
Street2:
* City: West Kingston County: Washington
* State: RI: Rhode Island
Province:
* Country: USA: UNITED STATES
* ZIP / Postal Code: 02892-1502 * Project/ Performance Site Congressional District: RI-002
I am submitting an application as an individual, and not on behalf of a company, state,
Project/Performance Site Location 1
local or tribal government, academia, or other type of organization.
Organization Name:
DUNS Number:
* Street1:
Street2:
* City: County:
* State:
Province:
* Country: USA: UNITED STATES
* ZIP / Postal Code: * Project/ Performance Site Congressional District:
Additional Location(s) Add Attachment Delete Attachment View Attachment
Performance Sites Page 4
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Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
RESEARCH & RELATED Other Project Information
1. * Are Human Subjects Involved? Yes No
1.a If YES to Human Subjects
Is the Project Exempt from Federal regulations? Yes No
If yes, check appropriate exemption number.
1 2 3 4 5 6
If no, is the IRB review Pending? Yes No
IRB Approval Date:
Human Subject Assurance Number:
2. * Are Vertebrate Animals Used? Yes No
2.a. If YES to Vertebrate Animals
Is the IACUC review Pending? Yes No
IACUC Approval Date:
Animal Welfare Assurance Number
3. * Is proprietary/privileged information included in the application? Yes No
4.a. * Does this project have an actual or potential impact on the environment? Yes No
4.b. If yes, please explain:
4.c. If this project has an actual or potential impact on the environment, has an exemption been authorized or an environmental assessment (EA) or
environmental impact statement (EIS) been performed? Yes No
4.d. If yes, please explain:
5. * Is the research performance site designated, or eligible to be designated, as a historic place? Yes No
5.a. If yes, please explain:
6. * Does this project involve activities outside of the United States or partnerships with international collaborators? Yes No
6.a. If yes, identify countries:
6.b. Optional Explanation:
7. * Project Summary/Abstract 1234-Project Abstract-Summary.pdf Add Attachment Delete Attachment View Attachment
8. * Project Narrative 1235-Narrative.pdf Add Attachment Delete Attachment View Attachment
9. Bibliography & References Cited Add Attachment Delete Attachment View Attachment
10. Facilities & Other Resources 1236-Facilities and Other Resources.p Add Attachment Delete Attachment View Attachment
11. Equipment Add Attachment Delete Attachment View Attachment
12. Other Attachments Add Attachments Delete Attachments View Attachments
Other Information Page 5
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Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
Project Summary/Abstract
The Gordon Research Conference (GRC) on Oxidative Stress and Disease is designed to
provide scientists from a wide range of disciplines with the latest research findings on the role of
oxidative stress in a variety of disease processes with emphasis on shared mechanisms. This
research conference has been held every 2 years since 1999; it is part of over 150 conferences
that will be organized in 2011 by the GRC, an organization internationally known for the high-
quality, cutting edge nature of its meetings. Although a comparatively young GRC conference,
attendance at the meeting has grown steadily since its inception over ten years ago.

The 2011 GRC on Oxidative Stress and Disease will be held March 14-18, 2011 at the Sheraton
Four Point/Holiday Inn Express in Ventura, CA. The program for the meeting described in this
application has been assembled around the theme of “Emerging research areas in the study
of oxidative stress and disease” which have recently collectively changed the way in which
we think about the impact of oxidative stress on cellular mechanisms involved in human
disease. These will include the impact of oxidative stress on, for example, epigenetics,
microRNAs, stem cells, and mitochondrial dynamics. Findings associated with these novel
areas of research are in turn likely to affect the manner in which basic research is translated into
interventions for oxidative stress-related disorders. This Gordon Research Conference will bring
together leading international experts with a broad range of interests related to diverse aspects
of oxidative stress and disease and will create a high quality scientific forum for discussion of
the latest findings on basic mechanisms and their translational implementation into interventions
aimed at novel disease therapies. In addition, for the first time in the history of this conference, a
pre-conference Gordon-Kenan Research Seminar will be organized by junior investigators at
the postdoctoral level. Activities during the Seminar will be oriented to junior investigators and
are intended to: (1) provide them with the basic background on common mechanisms involved
in oxidative stress and disease necessary to maximize their understanding of the science which
will be discussed in the subsequent conference, (2) receive feedback on their ongoing research
projects from experts in the field, and (3) facilitate their interaction with senior members of this
scientific community to promote networking between junior and more senior researchers in the
field. We fully anticipate that the scientific discussions, research talks, poster sessions, and
other informal interactions between the participants of this conference will contribute to
advancing our understanding of novel molecular mechanisms involved in oxidative stress-
related human disease and will set the basis for the development of collaborative interventions
aimed at promoting new therapeutic treatments for these disorders.

Project Description Page 6
Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
Narrative
The Gordon Research Conference on Oxidative Stress and Disease together with the pre-
meeting Gordon Kenan Research Seminar will bring together leaders in a variety of scientific
disciplines relevant to the study of oxidative stress-related disorders and junior investigators
constituting the future generation of researchers in this field. The scientific presentations,
discussions and workshops during this conference are designed to expand our understanding of
the mechanisms by which oxidative stress may contribute to disease processes. It is anticipated
that the collegial and cooperative atmosphere that has traditionally characterized this
conference will provide the perfect setting for the intellectual development and implementation
of novel therapeutics for this set of related diseases.

Public Health Relevance Statement Page 7
Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
Facilities and Other Resources
The Gordon Research Center, under the direction of Dr. Nancy Ryan Gray, will be responsible
for the organization and advertisement of the GRC and GRS meetings. The Conference and
Seminar will be held at the Four Points Sheraton/Holiday Inn Express in Ventura, California, just
70 miles north of Los Angeles and 30 miles south of Santa Barbara. Public transport is available
to the site from LAX, Santa Barbara, Oxnard, and Burbank airports. The Gordon Research
Center will take responsibility for all arrangements regarding housing, food service and
registration of participants of this conference and symposium, while scientific matters (selection
of speakers, session chairs, and participants) are the responsibility of the Conference andn
Seminar Chairs, Drs. Julie Andersen and Michael Brownlee and Drs. Almas Siddiqui and Aric
Rogers, respectively. A maximum of 200 scientists will be admitted to the GRC conference and
we expect 50 to attend the pre-meeting GRS. All housing, meeting and poster sessions will be
located within the hotel complex. It contains an exercise room, heated pool, licensed bar and
wireless access throughout the hotel. The hotel is located on 17 acres along California’s Gold
Coast on the Ventura Harbor providing access to surfing, fishing, whale-watching, wine-tasting,
golfing and tennis and nearby shopping and dining venues.

Facilities Page 8
Principal Investigator/Program Director (Last, first, middle): Andersen, Julie, Kay
OMB Number: 4040-0001
Expiration Date: 06/30/2011
RESEARCH & RELATED Senior/Key Person Profile (Expanded)
PROFILE - Project Director/Principal Investigator
Prefix: Dr. * First Name:Julie Middle Name: Kay
* Last Name: Andersen Suffix: Ph.D.
Position/Title: Professor Department:
Organization Name:Buck Institute for Age Research Division:
* Street1: 8001 Redwood Blvd.
Street2:
* City: Novato County/ Parish: Marin
* State: CA: California Province:
* Country: USA: UNITED STATES * Zip / Postal Code: 94945-1400
* Phone Number:415-209-2070 Fax Number: 415-209-2231
* E-Mail: [email protected]
Credential, e.g., agency login:JULIEANDERSEN
* Project Role: PD/PI Other Project Role Category:
Degree Type:
Degree Year:
*Attach Biographical Sketch 1241-AndersenNIHBioGRC.pdf Add Attachment Delete Attachment View Attachment
Attach Current & Pending Support Add Attachment Delete Attachment View Attachment
PROFILE - Senior/Key Person 1
Prefix: * First Name: Middle Name:
* Last Name: Suffix:
Position/Title: Department:
Organization Name: Division:
* Street1:
Street2:
* City: County/ Parish:
* State: Province:
* Country: USA: UNITED STATES * Zip / Postal Code:
* Phone Number: Fax Number:
* E-Mail:
Credential, e.g., agency login:
* Project Role: Other Project Role Category:
Degree Type:
Degree Year:
*Attach Biographical Sketch Add Attachment Delete Attachment View Attachment
Attach Current & Pending Support Add Attachment Delete Attachment View Attachment
Key Personnel Page 9
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