physical stability of agrochemical formulations

23 Pages·2017·2.03 MB·English

Brings to you the webinar on...
PHYSICAL STABILITY OF AGROCHEMICAL
FORMULATIONS
From Suspension to emulsion
Presented by:Dr. Martin Viertelhaus,
BASF SE
13th June 2017
Your Speaker
Dr. Martin Viertelhaus
Dr. Martin Viertelhaus is Research Scientist Crystalline Materials and Polymorphism at
BASF SE, Ludwigshafen, Germany.
His expertise is in the field of solid state development and physicochemical
characterization of active ingredients: e.g. agrochemical, pharmaceutical and
performance chemicals. During his professional career, he worked for pharmaceutical
and chemical companies as well as for a service provider.
 This webinar is being recorded and will be made available
The audience is muted and send the questions to
[email protected]
This webinar will last 45 minutes
TECHNOBIS CRYSTALLIZATION SYSTEMS
 Privately owned company
 50 employees
 LocatedinAlkmaar, The Netherlands
 Leader in 3 major markets: Pharma, Agro
and Fine Chemicals
Portfolio
 3 products for: formulation,
process optimization and
crystallization related research
Products
Discover
Working volume:
• Early stage salt, polymorph screening
0.06 – 0.1 ml
• Single crystal growth
32 reactors
Screen
• Solubility, MSZW
Working volume:
• Phase diagrams
0.5 – 1 ml
• Selecting solvents
16 reactors
• Polymorphs, Salt and Co-crystals
screening
Optimize
• Form control
Working volume:
• Habit control
• Particle size 2.5 – 5 ml
• Process optimization 8 reactors
• Formulation
Physical Stability of Agrochemical
Formulations
150 Jahre
From Suspension to Emulsion
Dr. Martin Viertelhaus
5
Overview
 solid state properties
 agrochemicals and their formulations
 two active ingredients …
 … plus formulants
 re-crystallization
Agrochemical Formulation, Suspension, Emulsion, M. Viertelhaus 6
Solid State Properties
 solid state properties depend on the crystal form
 knowledge about (meta)stable solid forms of active ingredients (AIs) is
important for
 production
 formulation
 storage
 application
new
lead marketing/
development registration production IP protection generation
optimization sales
products
Agrochemical Formulation, Suspension, Emulsion, M. Viertelhaus 7
Formulation and
Solid State of Active Ingredient
Agrochemical Formulation, Suspension, Emulsion, M. Viertelhaus 8
Agrochemicals
 indications
 fungicides (F)
 herbicides (H)
 insecticides (I)
 product application
 formulated concentrate
 dilution in water
(compatibility with water)
 application to fields
Agrochemical Formulation, Suspension, Emulsion, M. Viertelhaus 9
Agrochemical Formulation
 formulation development
 high active loading
 low viscosity (liquid)
 easy to dissolve/disperse (solid)
 storage stability
 2 years at ambient temperature
 2 weeks @ 54°C (accelerated)
 application stability
 robustness in biological tests
Agrochemical Formulation, Suspension, Emulsion, M. Viertelhaus 10