Oncology in Primary Care

443 Pages·2013·8.288 MB·English

by  Dr. Michal Rose MD

(c) 2015 Wolters Kluwer. All Rights Reserved.
Oncology in
Primary Care
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd ii 22//1199//1133 22::1199 PPMM
Oncology in
Primary Care

Senior Editors Associate Editors
Michal G. Rose, MD Kevin C. Oeffi nger, MD
Associate Professor of Medicine (Medical Oncology) Member and Attending Physician
Yale University School of Medicine Director, Memorial Sloan-Kettering Cancer Center
Director, Veterans Affairs CT Comprehensive Adult Long-Term Follow-Up Program
Cancer Center Departments of Medicine and Pediatrics
West Haven, CT Memorial Sloan-Kettering Cancer Center
New York, NY
Vincent T. DeVita Jr, MD
Amy and Joseph Perella Professor of Medicine Thomas L. Schwenk, MD
Yale Cancer Center and Smilow Cancer Hospital at Dean, School of Medicine
Yale-New Haven Vice President for Health Sciences
Yale University School of Medicine; University of Nevada
Professor of Epidemiology and Public Health Reno, NV
Yale University School of Public Health
New Haven, CT Richard C. Wender, MD
Alumni Professor & Chair
Theodore S. Lawrence, MD, PhD Department of Family & Community Medicine
Isadore Lampe Professor and Chair Thomas Jefferson University
Department of Radiation Oncology President, JeffCare (Jefferson’s Physician-Hospital
University of Michigan Organization)
Ann Arbor, MI Thomas Jefferson University Hospitals, Inc.
Philadelphia, PA
Steven A. Rosenberg, MD, PhD
Chief of Surgery, National Cancer Institute,
National Institutes of Health;
Professor of Surgery, Uniformed Services University
of the Health Sciences School of Medicine
Bethesda, MD;
Professor of Surgery, George Washington University
School of Medicine and Health Sciences
Washington, DC
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd iiiiii 22//1199//1133 22::1199 PPMM
Executive Editor: Rebecca Gaertner
Senior Product Manager: Kristina Oberle
Production Product Manager: David Orzechowski
Senior Manufacturing Coordinator: Beth Welsh
Senior Marketing Manager: Kimberly Schonberger
Design Coordinator: Teresa Mallon
Production Service: Absolute Service, Inc.
© 2013 by LIPPINCOTT WILLIAMS & WILKINS, a Wolters Kluwer business
Two Commerce Square
2001 Market Street
Philadelphia, PA 19103
All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including
photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except
for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their
offi cial duties as U.S. government employees are not covered by the above-mentioned copyright.
Printed in China
Library of Congress Cataloging-in-Publication Data
Oncology in primary care / senior editors, Michal G. Rose ... [et al.].
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4511-1149-1 — ISBN 1-4511-7599-X
I. Rose, Michal G.
[DNLM: 1. Neoplasms—diagnosis. 2. Neoplasms—therapy. 3. Primary Health Care—methods. 4. Risk Assessment. QZ 241]
RC261.A1
616.99'4—dc23
2013003256
Care has been taken to confi rm the accuracy of the information presented and to describe generally accepted practices. However, the
authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information
in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the
publication. Application of the information in a particular situation remains the professional responsibility of the practitioner.
The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in
accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in
government regulations, and the constant fl ow of information relating to drug therapy and drug reactions, the reader is urged to check
the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly
important when the recommended agent is a new or infrequently employed drug.
Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in
restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned
for use in their clinical practice.
To purchase additional copies of this book, call our customer service department at [phone] or fax orders to [phone].
International customers should call [phone].
Visit Lippincott Williams & Wilkins on the Internet at LWW.com. Lippincott Williams & Wilkins customer service representatives
are available from 8:30 am to 6 pm, EST.
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd iivv 22//1199//1133 22::1199 PPMM
To the memory of my parents,
Mrs. Sheila Ben-Tuvia and Professor Adam Ben-Tuvia
Michal G. Rose, MD
To Dr. Richard Kaufman
Vincent T. DeVita Jr, MD
To my wife Wendy
Theodore S. Lawrence, MD, PhD
To Alice
Steven A. Rosenberg, MD, PhD
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd vv 22//1199//1133 22::1199 PPMM
Contributors
Donald I. Abrams, MD Shrujal S. Baxi, MD, MPH
San Francisco General Hospital Assistant Attending Physician
San Francisco, California Head and Neck Oncology Service
Memorial Sloan-Kettering Cancer Center
Carlos Acevedo-Gadea, MD Instructor of Medicine
Clinical Fellow Weill Cornell Medical College
Yale Cancer Center New York, New York
Yale School of Medicine
New Haven, Connecticut Ann M. Berger, MSN, MD
Bethesda, MD
Tim Ahles, PhD
Director of the Neurocognitive Research Laboratory Smita Bhatia, MD, MPH
Memorial Sloan-Kettering Cancer Center Chair and Professor, Population Sciences
New York, New York City of Hope National Medical Center
Duarte, California
Manmeet S. Ahluwalia, MD
Section Head, Neuro-Oncology Outcomes Daniel J. Boffa, MD
The Rose Ella Burkhardt Brain Tumor and Assistant Professor
Neuro-Oncology Center Department of Thoracic Surgery
Neurological Institute, Cleveland Clinic Yale University School of Medicine
Assistant Professor, Department of Medicine Attending
Cleveland Clinic Lerner College of Medicine of Case Western Yale-New Haven Hospital
Reserve University New Haven, Connecticut
Cleveland, Ohio
Danielle C. Bonadies, MS, CGC
Richard B. Alexander, MD Assistant Director, Cancer Genetic Counseling
Professor Yale Cancer Center
Department of Surgery/Urology New Haven, Connecticut
University of Maryland School of Medicine
Chief, Urology Michael Boyiadzis, MD, MHSc
Veterans Affairs Maryland Health Care System Assistant Professor of Medicine
Baltimore, Maryland University of Pittsburgh School of Medicine
University of Pittsburgh Cancer Institute
Richard J. Barth Jr, MD Pittsburgh, Pennsylvania
Associate Professor
Department of Surgery Eduardo Bruera, MD
The Geisel School of Medicine at Dartmouth Professor and Chair
Chief of Surgical Oncology Department of Palliative Care and Rehabilitation Medicine
Dartmouth-Hitchcock Medical Center The University of Texas MD Anderson Cancer Center
Lebanon, New Hampshire Houston, Texas
Chiara Battelli, MD, PhD Christina Brzezniak, DO
Clinical and Research Fellow Clinical Fellow
Division of Hematology-Oncology Hematology and Oncology
Department of Medicine Walter Reed National Military Medical Center
Harvard Medical School Bethesda, Maryland
Beth Israel Deaconess Medical Center
Boston, Massachusetts Tim Byers, MD, MPH
Associate Dean for Public Health Practice
Colorado School of Public Health
Aurora, Colorado
vii
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd vviiii 22//1199//1133 22::1199 PPMM
viii Oncology in Primary Care
Gayle L. Byker, MD, MBA Allen J. Dietrich, MD
Hospice Medical Director Professor
Capital Caring Department of Community and Family Medicine
Falls Church, Virginia Norris Cotton Cancer Center
Geisel School of Medicine at Dartmouth
Bryan W. Chang, MD Hanover, New Hampshire
Assistant Professor
Radiation Oncology Barbara K. Dunn, MD, PhD
Yale University School of Medicine Medical Offi cer
Physician Division of Cancer Prevention
Yale-New Haven Hospital National Cancer Institute
New Haven, Connecticut Bethesda, Maryland
Herta H. Chao, MD, PhD Laura J. Esserman, MD, MBA
Associate Professor of Medicine Professor of Surgery and Radiology
Yale School of Medicine University of California, San Francisco
Veterans Affairs Cancer Center Director, Carol Franc Buck Breast Care Center
West Haven, Connecticut Helen Diller Family Comprehensive Cancer Center
University of California, San Francisco
Wichai Chinratanalab, MD San Francisco, California
Assistant Professor of Medicine
Division of Hematology/Oncology Daniel G. Federman, MD, FACP
Vanderbilt University School of Medicine Professor of Medicine
Nashville, Tennessee Yale University School of Medicine
Chief in Primary Care
Gina G. Chung, MD Veterans Affairs Connecticut Healthcare System
Assistant Professor West Haven, Connecticut
Yale Cancer Center
Yale University School of Medicine Michael Feuerstein, PhD
Attending Physician Professor of Medical and Clinical Psychology and Preventive
Internal Medicine Medicine and Biometrics
Yale New Haven Hospital Uniformed Services University of the Health Sciences
New Haven, Connecticut Bethesda, Maryland
Lauren G. Collins, MD Aaron W. Flanders, MD
Assistant Professor Hematology and Oncology Fellow
Department of Family and Community Medicine Walter Reed National Military Medical Center
Jefferson Medical College/Thomas Jefferson University Bethesda, Maryland
Philadelphia, Pennsylvania
Christopher Ian Flowers, MD, FRCR
Alicia J. Cool, MD Associate Professor
Procedural Dermatology Fellow Department of Oncological Sciences
Yale Department of Dermatology University of South Florida
Section of Dermatologic Surgery and Cutaneous Oncology Director of Breast Imaging
Yale University School of Medicine Moffi tt Cancer Center
Yale New Haven Hospital Tampa, Florida
New Haven, Connecticut
Kenneth A. Foon, MD
Shalini Dalal, MD Vice President, Medical Affairs
Assistant Professor Celgene Corporation
Department of Palliative Care and Rehabilitation Medicine Summit, New Jersey
The University of Texas MD Anderson Cancer Center
Houston, Texas Danielle N. Friedman, MD
Instructor, Department of Pediatrics
Barbara A. Degar, MD Long-Term Follow-Up Program
Assistant Professor in Pediatrics Memorial Sloan-Kettering Cancer Center
Harvard Medical School New York, New York
Senior Physician in Pediatric Oncology
Dana-Farber Cancer Institute/Boston Children’s Hospital Scott Nicholas Gettinger, MD
Cancer Center Associate Professor of Medicine
Boston, Massachusetts Yale University School of Medicine
Yale Cancer Center
Aarati D. Didwania, MD New Haven, Connecticut
Associate Professor
General Internal Medicine and Geriatrics
Feinberg School of Medicine, Northwestern University
Chicago, Illinois
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd vviiiiii 22//1199//1133 22::1199 PPMM
CONTRIBUTORS ix
Shari Goldfarb, MD Susan Hong, MD, MPH
Assistant Attending Physician Associate Professor of Medicine
Departments of Medicine and Epidemiology and Biostatistics, Department of Medicine
Memorial Sloan-Kettering Cancer Center University of Chicago
Department of Medicine, Weill Cornell Medical College Chicago, Illinois
New York, New York
Bonnie Indeck, MSW, LCSW
Stacey A. Goodman, MD Manager, Oncology Social Work
Professor of Medicine Smilow Cancer Hospital at Yale-New Haven
Division of Hematology/Oncology New Haven, Connecticut
Department of Medicine, Vanderbilt University
Nashville, Tennessee Iris Isufi , MD
Assistant Professor of Medicine, Hematology
Elon J. Granader, MD, MSc Yale University School of Medicine
Department of Radiology New Haven, Connecticut
University of Michigan Health System
Ann Arbor, Michigan Ahmedin Jemal, DVM, PhD
Vice President, Surveillance and Health Services Research
F. Anthony Greco, MD National Home Offi ce
Director, Sarah Cannon Cancer Center American Cancer Society, Inc
Centennial Medical Center Atlanta, Georgia
Nashville, Tennessee
Nirav S. Kapadia, MD
Peter Greenwald, MD, DrPH Department of Radiation Oncology
Associate Director for Prevention University of Michigan Health System
National Cancer Institute Ann Arbor, Michigan
Bethesda, Maryland
Kristen Kellar-Graney, MS
John D. Hainsworth, MD Tumor Biologist and Clinical Researcher
Chief Scientifi c Offi cer Washington Musculoskeletal Tumor Center
Sarah Cannon Research Institute Bethesda, Maryland
Nashville, Tennessee
Joanne Frankel Kelvin, RN, MSN
Diane M. Harper, MD, MPH, MS Clinical Nurse Specialist
Professor and Vice Chair Survivorship
Department of Obstetrics and Gynecology Memorial Sloan-Kettering Cancer Center
Community and Family Medicine New York, New York
University of Missouri-Kansas City School of Medicine
Chief of Women’s Health Amsale Ketema, MD
Truman Medical Center Lakewood Assistant Clinical Member at Memorial Sloan-Kettering
Kansas City, Missouri Cancer Center
Assistant Professor of Clinical Medicine at Weill Cornell
Alton Hart Jr, MD, MPH Medical College
Associate Scientifi c Director New York, New York
Virginia Commonwealth University
Richmond, Virginia Robert S. Kirsner, MD, PhD
Professor and Vice Chairman
Tara O. Henderson, MD, MPH Department of Dermatology and Cutaneous Surgery
Assistant Professor University of Miami Miller School of Medicine
Department of Pediatrics, Section of Hematology, Oncology and Chief of Dermatology
Stem Cell Transplantation University of Miami Hospital
University of Chicago Miami, Florida
Chicago, Illinois
Manish Kohli, MD
Howard S. Hochster, MD Associate Professor of Oncology
Professor of Medicine, Medical Oncology Chair, Genito-Urinary Medical Oncology
Associate Director for Clinical Research, Yale Cancer Center Mayo Clinic
Clinical Program Leader, Gastrointestinal Cancers Program, Rochester, Minnesota
Smilow Cancer Hospital at Yale-New Haven
Clinical Research Program Leader, Gastrointestinal Cancers Marisa A. Kollmeier, MD
Program, Yale Cancer Center Assistant Professor, Attending Physician
Yale University School of Medicine Department of Radiation Oncology
New Haven, Connecticut Memorial Sloan-Kettering Cancer Center
New York, New York
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd iixx 66//2288//1133 44::4455 AAMM
x Oncology in Primary Care
Panagiotis A. Konstantinopoulos, MD, PhD Jack S. Mandel, PhD, MPH
Assistant Professor of Medicine Chief Science Offi cer
Medicine-Division of Hematology/Oncology Exponent, Inc
Harvard Medical School Menlo Park, California
Beth Israel Deaconess Medical Center
Boston, Massachusetts Anna Rita Marcelli, MD
Assistant Professor of Clinical Medicine
Amrita Y. Krishnan, MD, FACP Assistant Attending Physician
Associate Director, Medical Education and Training Memorial Sloan-Kettering Cancer Center
Director, Multiple Myeloma Program New York, New York
Department of Hematology and Hematopoietic
Cell Transplantation Steven C. Martin, MD
City of Hope Medical Center Member
Duarte, California Department of Medicine
Memorial Sloan-Kettering Cancer Center
Elizabeth A. Kvale, MD Chief, General Internal Medicine
Associate Professor Memorial Hospital for Cancer and Allied Diseases
Department of Medicine, Director Supportive Care New York, New York
University of Alabama at Birmingham
Staff Physician Ellen T. Matloff, MS, CGC
Palliative Medicine Research Scientist, Department of Genetics
Birmingham Veterans Affairs Medical Center Yale School of Medicine
Birmingham, Alabama Director, Cancer Genetic Counseling
Yale Cancer Center
Jill Lacy, MD New Haven, Connecticut
Associate Professor
Director, Hematology-Oncology Fellowship Laura C. McCullough, MD
Program, Section of Medical Oncology General Pediatrician, Milton Pediatrics
Yale University School of Medicine Children’s Hospital Boston
Yale-New Haven Hospital Massachusetts General Hospital
New Haven, Connecticut Brigham and Women’s Hospital
Beth Israel Deaconess Medical Center
Theodore S. Lawrence, MD, PhD, FASTRO Boston, Massachusetts
Isadore Lampe Professor and Chair
Department of Radiation Oncology Aleagia Mercer-Falkoff, MD
University of Michigan Mercy Medical Center
Ann Arbor, MI Baltimore, Maryland
David J. Leffell, MD Lindsay M. Morton, PhD
David Paige Smith Professor of Dermatology and Surgery Investigator, Radiation Epidemiology Branch
Yale School of Medicine Division of Cancer Epidemiology and Genetics
New Haven, Connecticut National Cancer Institute
Rockville, Maryland
Jia Li, MD, PhD
Assistant Professor of Medicine Anil B. Nagar, MD
Yale School of Medicine Associate Professor
New Haven, Connecticut Internal Medicine, Digestive Diseases
Yale University
Jennifer E. Liu, MD, FACC New Haven, Connecticut
Director of Cardiovascular Laboratories Endoscopy Director
Memorial Sloan-Kettering Cancer Center West Haven Veterans Affairs Medical Center
New York, New York West Haven, Connecticut
Konstantinos I. Makris, MD Nitya Nathwani, MD
Endocrine Surgery Fellow Assistant Professor
Department of Surgery Department of Hematology and Hematopoietic
The Johns Hopkins University School of Medicine Cell Transplantation
Baltimore, Maryland City of Hope Medical Center
Duarte, California
Martin M. Malawer, MD, FACS
Director of Orthopedic Oncology Larissa Nekhlyudov, MD, MPH
Professor of Orthopedic Surgery, George Washington University Associate Professor
Professor (Clinical Scholar) in Orthopedics, Georgetown Department of Population Medicine
University School of Medicine Harvard Medical School
Washington, District of Columbia Primary Care Physician
Department of Medicine
Harvard Vanguard Medical Associates
Boston, Massachusetts
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd xx 22//1199//1133 22::1199 PPMM
CONTRIBUTORS xi
Leslie Nowell, DO Michelle B. Riba, MD, MS
Showa Associates’ Wellness Center Clinical Professor and Associate Chair
Sunbury, Ohio Department of Psychiatry
University of Michigan
Sasha Nunes Ann Arbor, Michigan
Dietetic Intern
Sodexo Mid-Atlantic Dietetic Internship Nora Rightmer, LCSW
Washington, District of Columbia Clinical Oncology Social Worker
Smilow Cancer Hospital at Yale-New Haven
Kevin C. Oeffi nger, MD New Haven, Connecticut
Member and Attending Physician
Director, Memorial Sloan-Kettering Cancer Center Michal G. Rose, MD
Adult Long-Term Follow-Up Program Associate Professor of Medicine (Medical Oncology)
Departments of Medicine and Pediatrics Yale University School of Medicine
Memorial Sloan-Kettering Cancer Center Director, Veterans Affairs CT Comprehensive Cancer Center
New York, New York West Haven, Connecticut
Susan M. Parks, MD Robert E. Roses, MD
Associate Professor Assistant Professor of Surgery
Department of Family and Community Medicine Hospital of the University of Pennsylvania
Thomas Jefferson University University of Pennsylvania School of Medicine
Philadelphia, Pennsylvania Philadelphia, Pennsylvania
Kimberly S. Peairs, MD Richard E. Royal, MD
Assistant Professor Associate Professor
Department of Medicine and The Sidney Kimmel Department of Surgical Oncology
Comprehensive Cancer Center University of Texas
Johns Hopkins University School of Medicine Gastrointestinal and Melanoma Centers
Lutherville, Maryland M.D. Anderson Cancer Center
Assistant Professor of Medicine Houston, Texas
Johns Hopkins Hospital
Baltimore, Maryland Marina Rozenberg, MD
Assistant Clinical Member
David G. Pfi ster, MD Memorial Sloan-Kettering Cancer Center
Professor New York, New York
Department of Medicine
Weill Cornell Medical College Mack T. Ruffi n, IV, MD
Member, Attending Physician Dr. Max and Buena Lichter Research Professor
Chief, Head and Neck Oncology Service Associate Chair for Research Programs
Memorial Sloan-Kettering Cancer Center Department of Family Medicine
New York, New York University of Michigan
Ann Arbor, Michigan
Mark P. Purdue, PhD
Investigator Shannon Ryan-Cebula, MD
Division of Cancer Epidemiology and Genetics Bethesda, Maryland
National Cancer Institute
Bethesda, Maryland Hamid Saadati, MD
Hematology Oncology Fellow
Mohammad Ali Raza, MD Smilow Cancer Hospital at Yale-New Haven
Clinical Fellow New Haven, Connecticut
Medical Oncology/Hematology
Yale University Bipin N. Savani, MD
Yale Cancer Center Associate Professor of Medicine
New Haven, Connecticut Director, Long-Term Transplant Clinic
Hematology and Stem Cell Transplantation Section
Alvin L. Reaves III, MD Vanderbilt University School of Medicine
Clinical Instructor of Medicine Nashville, Tennessee
Emory Palliative Care Center
Emory University Glenn L. Schattman, MD
Atlanta, Georgia Associate Professor of Clinical Reproductive Medicine
Associate Professor of Clinical Obstetrics and Gynecology
Nishitha M. Reddy, MD Weill Cornell Medical College
Assistant Professor of Medicine Associate Attending Physician, Reproductive Medicine
Vanderbilt-Ingram Cancer Center Associate Attending Obstetrician and Gynecologist
Nashville, Tennessee New York-Presbyterian Hospital/Weill Cornell Medical Center
New York, New York
(c) 2015 Wolters Kluwer. All Rights Reserved.
RRoossee FFMM..iinndddd xxii 22//1199//1133 22::1199 PPMM