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About LIM YI FEI Critical Reading
Guo et al. discovered that miRNA-939 directly regulates the human inducible Nitric Oxide Synthase (hiNOS) gene in human hepatocytes by binding to two miRNA response elements in the 3' untranslated region of the hiNOS mRNA. They found that miRNA-939 expression increases following cytokine induction and that it inhibits hiNOS gene expression by blocking hiNOS mRNA translation rather than degradation. Guo et al. conclude that miRNA-939 contributes to regulating NO synthesis to prevent over-expression of hiNOS. However, the author of this review critiques some of Guo et al.'s conclusions and argues that their presentation lacked completeness and coherence.
Detailed Information
| Author: | ['Lim Yi Fei'] |
|---|---|
| Publication Year: | 2015 |
| Pages: | 4 |
| Language: | English |
| Format: | |
| Price: | FREE |
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