Table Of Content- - - --
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Ninth Edition
Kumar & Clark's Clinical Medicine
NINTH EDITION
Edited by
Professor Parveen Kumar CBE BSc MD DM(HC)
FRCP(L&E) FRCPath
Professor of Medicine and Education, Barts and The London School of Medicine and
Dentistry, QMUL, and Honorary Consultant Physician and Gastroenterologist, Barts Health
NHS Trust and Homerton University Hospital NHS Foundation Trust, UK
Dr Michael Clark MD FRCP
Honorary Senior Lecturer, Barts and The London School of Medicine and Dentistry, QMUL,
and Princess Grace Hospital, UK
Editor, Online Content
Adam Feather FRCP FAcadMEd
Senior Lecturer in Medical Education and Clinical Lead in Acute Medicine, The Royal
London Hospital, Barts Health NHS Trust, UK
Edinburgh London New York Oxford Philadelphia St Louis
Sydney Toronto 2017
Table of Contents
Cover image
Title Page
Copyright
Acknowledgements
Online Special Topics
Contributors
Online contributors
International Advisory Board
Preface to the Ninth Edition
How to Use This Book
Section 1 Good medical practice
1 Ethics, law and communication
Ethics and the Law
Communication
2 Clinical pharmacology
Introduction
Why Do Patients Need Drugs?
The Choice of Drug
The Dose
Pharmacokinetics
Pharmacodynamics
Affordability and Cost-Effectiveness
Prescribing in Special Populations
Monitoring Drug Therapy
Adverse Drug Reactions
Drug Interactions
Inter-Individual Variability in Drug Response
Evidence-Based Medicine
Statistical Analyses
Information Sources
Significant websites
3 Palliative medicine and symptom control
Introduction and General Aspects
Symptom Control
Extending Palliative Care to People with Non-Malignant Disease
Palliative Care of the Frail Elderly
Care of the Dying
Further reading
Bibliography
Significant websites
4 Global health
Introduction
Millennium Development Goals
Global Burden of Disease
Poverty
Water and Sanitation
Organizations and the Global Health Agenda
Education
Maternal Health and Child Health
Mental Health
Accidents and Trauma
Conflict and Catastrophe
Economics and Politics in Global Health
Social Determinants of Health
Human Rights and the Value of Engagement in Global Health
Bibliography
5 Environmental medicine
Disease and the Environment
Environmental Temperature
Heat Injury
Cold Injury
High Altitude
Diving
Drowning
Air Pollution
Ionizing Radiation
Electric Shock
Lightning Strike
Smoke
Noise
Bioterrorism/Biowarfare
Travel
Building-Related Illnesses
6 Poisoning
Introduction
Clinical approach to the poisoned patient
Principles of Management of Poisoning
Specific Poisons
Significant websites
Section 2 Clinical sciences
7 Molecular cell biology and human genetics
Cell Biology
Human Genetics
Bibliography
Significant websites
8 The immune system and disease
Anatomy and Principles of the Immune System
Innate Immune System
Adaptive Immune System
Cell Migration
HLA Molecules and Antigen Presentation
The Immune System in Concert
Laboratory Investigations of the Immune System
Clinical Immunodeficiency
Type I (Immediate) Hypersensitivity and Allergic Disease
Autoimmune Disease
Organ Rejection in Clinical Transplantation
Immune-Based Therapies
9 Water, electrolytes and acid–base balance
Water and Electrolytes
Acid–Base Disorders
Further reading
Bibliography
10 Nutrition
Introduction
Water and Electrolyte Balance
Dietary Requirements
Protein–Energy Malnutrition
Vitamins
Minerals
Nutrition and Ageing
Obesity
Nutritional Support
Food Allergy and Food Intolerance
Alcohol
Bibliography
Significant websites
Section 3 Clinical practice
11 Infectious diseases and tropical medicine
Infection and Infectious Disease
Viral Infections
Transmissible Spongiform Encephalopathies (Prion Diseases)
Bacterial Infections
Fungal Infections
Protozoal Infections
Helminthic Infections
Arthropod Ectoparasites
12 Sexually transmitted infections and human immunodeficiency virus
Sexually Transmitted Infections
Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
Bibliography
13 Gastrointestinal disease
Introduction
Clinical Approach to the Patient with Gastrointestinal Disease
The Mouth
The Salivary Glands
The Pharynx and Oesophagus
The Stomach and Duodenum
Acute and Chronic Gastrointestinal Bleeding
The Small Intestine
Inflammatory Bowel Disease
The Colon and Rectum
Diarrhoea
Functional Gastrointestinal Disorders
The Acute Abdomen
The Peritoneum
Bibliography
Significant websites
14 Liver disease
Introduction
Anatomy of the Liver and Biliary System
Functions of the Liver
Clinical Approach to the Patient with Liver Disease
Jaundice
Hepatitis
Acute Hepatic Failure
Autoimmune Hepatitis
Drug-Induced Chronic Hepatitis
Chronic Hepatitis of Unknown Cause
Non-Alcoholic Fatty Liver Disease
Cirrhosis
Alcoholic Liver Disease
Budd–Chiari Syndrome
Hepatic Sinusoidal Obstruction Syndrome
Fibropolycystic Diseases
Liver Abscess
Other Infections of the Liver
Liver Disease in Pregnancy
Liver Tumours
Miscellaneous Conditions of the Liver
Drugs and the Liver
Bibliography
15 Biliary tract and pancreatic disease
The Gall Bladder and Biliary System
The Pancreas
16 Haematological disease
The Red Cell
The Spleen
Blood Transfusion
The White Cell
Haemostasis and Thrombosis
Bibliography
Significant websites
17 Malignant disease
Cancer Treatment
Acute Oncology
Haematological Malignancies
Common Solid Tumour Treatment
18 Rheumatic disease
Introduction
Anatomy and Physiology of the Normal Joint
Clinical Approach to the Patient with Rheumatic Disease
Common Regional Musculoskeletal Problems
Chronic Pain Syndromes
Analgesic and Anti-Inflammatory Drugs for Musculoskeletal Problems
Disorders of collagen
Osteoarthritis
Inflammatory Arthritis
Rheumatoid arthritis
Infections of Joints
Autoimmune Rheumatic Diseases
Systemic Inflammatory Vasculitis
Arthritis in Children
Rheumatological Problems Seen in Other Diseases
Miscellaneous Arthropathies
