Table Of ContentIASLC Thoracic Oncology
SECOND EDITION
Executive Editor:
Harvey I. Pass, MD
Stephen E. Banner Professor of Thoracic Oncology
Vice Chairman of Research
Department of Cardiothoracic Surgery
New York University Langone Medical Center
New York, New York
Editors:
David Ball, MD, FRANZCR
Director
Lung Cancer Stream
Victorian Comprehensive Cancer Centre
Parkville Professional Fellow
The Sir Peter MacCallum Department of Oncology
The University of Melbourne
Melbourne, Australia
Giorgio V. Scagliotti, MD, PhD
Professor of Medical Oncology
Head of Department of Oncology at San Luigi Hospital
University of Turin
Orbassano, Turin, Italy
Deborah Whippen
Managing Editor
Editorial Rx, Inc.
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
IASLC THORACIC ONCOLOGY, SECOND EDITION ISBN: 978-0-323-52357-8
Copyright © 2018 International Association for the Study of Lung Cancer (IASLC).
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Previous edition copyrighted in 2014.
Library of Congress Cataloging-in-Publication Data
Names: Pass, Harvey I., editor. | Ball, David (David L.), editor. |
Scagliotti, Giorgio V., editor. | International Association for the Study
of Lung Cancer, issuing body.
Title: IASLC thoracic oncology / executive editor, Harvey I. Pass ; editors,
David Ball, Giorgio V. Scagliotti.
Other titles: The IASLC multidisciplinary approach to thoracic oncology. |
Thoracic oncology | International Association for the Study of Lung Cancer
thoracic oncology
Description: Second edition. | Philadelphia, PA : Elsevier, [2018] | Preceded
by: The IASLC multidisciplinary approach to thoracic oncology / executive
editor, Harvey I. Pass ; editors: David Ball, Giorgio V. Scagliotti.
[2014] | Includes bibliographical references and index.
Identifiers: LCCN 2017004620 | ISBN 9780323523578 (hardcover : alk. paper)
Subjects: | MESH: Thoracic Neoplasms
Classification: LCC RC280.C5 | NLM WF 970 | DDC 616.99/494--dc23 LC record available at
https://lccn.loc.gov/2017004620
Content Strategist: Kayla Wolfe
Director, Content Development: Taylor Ball
Publishing Services Manager: Patricia Tannian
Senior Project Manager: Sharon Corell
Book Designer: Brian Salisbury
Printed in China.
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Contributors
Alex A. Adjei, MD, PhD David Ball, MD, FRANZCR Julie R. Brahmer, MD
Professor Director Associate Professor of Oncology
Head Lung Cancer Stream Director of Thoracic Oncology
Early Cancer Therapeutics Program Victorian Comprehensive Cancer Centre Sidney Kimmel Comprehensive Cancer
Director Parkville Professional Fellow Center
Global Oncology Program The Sir Peter MacCallum Department of The Johns Hopkins University
Mayo Clinic Oncology Baltimore, Maryland, USA
Rochester, Minnesota, USA The University of Melbourne
Elisabeth Brambilla, MD, PhD
Melbourne, Australia
Mjung-Ju Ahn, MD, PhD Professor of Pathology
Professor Fabrice Barlesi, MD, PhD Grenoble University Hospital
Division of Hematology/Oncology Professor Grenoble, France
Department of Medicine Oncologie Multidisciplinaire et
Fraser Brims
Samsung Medical Center Innovations Thérapeutiques
Institute of Respiratory Health
Sungkyunkwan University School of Aix Marseille University
Department of Respiratory Medicine,
Medicine Assistance Publique Hôpitaux de Marseille
Sir Charles Gairdner Hospital
Seoul, South Korea Marseille, France
Curtin Medical School
Chris I. Amos, PhD Jose G. Bazan, MD, MS Faculty of Health Sciences
Associate Director for Population Assistant Professor Curtin University
Sciences Department of Radiation Oncology Perth, Australia
Department of Biomedical Data Science The Ohio State University
Alessandro Brunelli, MD
Geisel School of Medicine Columbus, Ohio, USA
Consultant Thoracic Surgeon
Dartmouth College
José Belderbos, MD, PhD Honorary Senior Lecturer
Hanover, New Hampshire, USA
Department of Radiation Oncology St. James’s University Hospital
Alberto Antonicelli, MD The Netherlands Cancer Institute— Leeds, United Kingdom
Section of Thoracic Surgery Antoni van Leeuwenhoek
Ayesha Bryant, MSPH, MD
Department of Surgery Amsterdam, The Netherlands
Assistant Professor
Yale University
Andrea Bezjak, BMedSc, MDCM, MSc, Section of Thoracic Surgery
New Haven, Connecticut, USA
FRCPC University of Alabama School of
Hisao Asamura, MD Professor Medicine
Professor of Surgery Department of Radiation Oncology Birmingham, Alabama, USA
Chief University of Toronto
Nicholas Campbell, MD
Division of Thoracic Surgery Princess Margaret Cancer Centre
Clinical Assistant Professor
Keio University School of Medicine Toronto, Ontario, Canada
NorthShore University HealthSystem
Tokyo, Japan
Lucinda J. Billingham, BSc, MSc, PhD, Kellog Cancer Center
Todd Atwood, PhD CStat Evanston, Illinois, USA
Department of Radiation Medicine and Professor of Biostatistics
Brett W. Carter, MD
Applied Sciences Cancer Research UK Clinical Trials Unit
Assistant Professor
University of California, San Diego Institute of Cancer and Genomic
Department of Diagnostic Radiology
La Jolla, California, USA Sciences
Division of Diagnostic Imaging
University of Birmingham
Paul Baas, MD, PhD The University of Texas MD Anderson
Birmingham, United Kingdom
Professor Cancer Center
Department of Thoracic Oncology Paolo Boffetta, MD, MPH Houston, Texas, USA
The Netherlands Cancer Institute Professor
Robert Cerfolio, MD, MBA, FCCP,
Amsterdam, The Netherlands Tisch Cancer Institute
FACS
Icahn School of Medicine at Mount Sinai
Joan E. Bailey-Wilson, PhD Professor
New York, New York, USA
Co-Chief and Senior Investigator Section of Thoracic Surgery
Computational and Statistical Genomics Martina Bonifazi, MD University of Alabama School of
Branch Department of Byomedic Sciences and Medicine
National Human Genome Research Public Health Birmingham, Alabama, USA
Institute Polytechnic University of Marche Region
Byoung Chul Cho, MD, PhD
National Institutes of Health Pulmonary Diseases Unit
Associate Professor
Baltimore, Maryland, USA Azienda Ospedali Riuniti
Yonsei Cancer Center
Ancona, Italy
Yonsei University College of Medicine
Seoul, Republic of Korea
v
vi CONTRIBUTORS
William C. S. Cho, PhD, Chartered Harry J. de Koning, MD, PhD Grace K. Dy, MD
Scientist, FIBMS Professor Associate Professor
Department of Clinical Oncology Department of Public Health Department of Medicine
Queen Elizabeth Hospital Erasmus University Medical Center Roswell Park Cancer Institute
Hong Kong, China Rotterdam, The Netherlands Buffalo, New York, USA
Hak Choy, MD Paul De Leyn, MD, PhD Jeremy J. Erasmus, MD
Professor Professor and Chief Professor
Department of Radiation Oncology Department of Thoracic Surgery Department of Diagnostic Radiology
University of Texas Southwestern University Hospitals Leuven Division of Diagnostic Imaging
Dallas, Texas, USA Leuven, Belgium The University of Texas MD Anderson
Cancer Center
Chia-Yu Chu, MD, PhD Dirk De Ruysscher, MD, PhD
Houston, Texas, USA
Associate Professor Maastricht University Medical Center
Department of Dermatology Department of Radiation Oncology Alysa Fairchild, BSc, MD, FRCPC
National Taiwan University Hospital and (Maastro Clinic) Associate Professor
National Taiwan University College of GROW School Department of Radiation Oncology
Medicine Maastricht, The Netherlands University of Alberta
Taipei, Taiwan Katholieke Universiteit Leuven Cross Cancer Institute
Radiation Oncology Edmonton, Alberta, Canada
Glenda Colburn, EMBA
Leuven, Belgium
National Director Dean A. Fennell, PhD, FRCP
Thoracic Cancers and Rare Lung Ayşe Nur Demiral, MD Professor of Thoracic Medical Oncology
Diseases Professor Cancer Research UK Centre
General Manager Department of Radiation Oncology University of Leicester and University
Research DokuzEylül University Medical School Hospitals of Leicester NHS Trust
Lung Cancer National Program Izmir, Turkey Leicester, United Kingdom
Lung Foundation Australia
Jules Derks, MD Hiran C. Fernando, MBBS, FRCS,
Queensland University of Technology
Department of Pulmonology FRCSEd
Milton, Australia
Maastricht University Medical Center Co-Director
Henri Colt, MD Maastricht, The Netherlands Thoracic Oncology
Professor Emeritus ISCI Thoracic Section
Frank C. Detterbeck, MD
School of Medicine Department of Surgery
Professor
University of California, Irvine Inova Fairfax Medical Campus
Section of Thoracic Surgery
Orange, California, USA Falls Church, Virginia, USA
Department of Surgery
Rafael Rosell Costa, MD Yale University Pier Luigi Filosso, MD
Director New Haven, Connecticut, USA Associate Professor of Thoracic Surgery
Cancer Biology and Precision Medicine University of Turin
Siddhartha Devarakonda
Program Turin, Italy
Fellow
Catalan Institute of Oncology
Division of Medical Oncology/Hematology Raja Flores, MD
Germans Trias i Pujol Health Sciences
Department of Medicine Professor
Institute and Hospital
Washington University School of Department of Thoracic Surgery
Associate Professor of Medicine
Medicine Mount Sinai Medical Center
Autonomous University of Barcelona
St. Louis, Missouri, USA New York, New York, USA
(UAB) Campus Can Ruti
Barcelona, Spain Anne-Marie C. Dingemans, MD, PhD Kwun Fong, MBBS (Lon), FRACP, PhD
Pulmonologist Department of Thoracic Medicine
Gail E. Darling, MD, FRCSC, FACS
Department of Pulmonology The Prince Charles Hospital
Professor
Maastricht University Medical Center University of Queensland Thoracic
Division of Thoracic Surgery
Maastricht, The Netherlands Research Centre
Department of Surgery
Brisbane, Australia
University of Toronto Jessica S. Donington, MD, MSCr
Toronto, Ontario, Canada Associate Professor Jesme Fox, MB, ChB, MBA
Department of Cardiothoracic Surgery Medical Director
Mellar Davis, MD, FCCP, FAAHPM
New York University School of Medicine Roy Castle Lung Cancer Foundation
Director of Palliative Care
New York, New York, USA Liverpool, United Kingdom
Geisinger Medical System
Danville, Pennsylvania, USA Carolyn M. Dresler, MD, MPA David R. Gandara, MD
Professor of Medicine President Professor
Cleveland Clinic Lerner School of Human Rights and Tobacco Control Thoracic Oncology Program
Medicine Network Division of Medical Oncology
Case Western Reserve University Rockville, Maryland, USA University of California Davis
Cleveland, Ohio, USA Comprehensive Cancer Center
Steven M. Dubinett, MD
Sacramento, California, USA
Patricia M. de Groot, MD Professor
Associate Professor Division of Pulmonary and Critical Care Leena Gandhi, MD, PhD
Department of Diagnostic Radiology Medicine Director of Thoracic Medical Oncology
Division of Diagnostic Imaging David Geffen School of Medicine at UCLA Laura and Isaac Perlmutter Cancer Center
The University of Texas MD Anderson UCLA Clinical and Translational New York University Langone Medical
Cancer Center Science Institute Center
Houston, Texas, USA Los Angeles, California, USA New York, New York, USA
CONTRIBUTORS vii
Laurie Gaspar, MD, MBA, FACR, Alissa K. Greenberg, MD David M. Jablons, MD
FASTRO Pulmonary Group Professor and Chief Thoracic Surgery
Professor Northeast Medical Group, Inc. UCSF Department of Surgery
Department of Radiation Oncology New York, New York, USA Nan T. McEvoy Distinguished Professor
University of Colorado of Thoracic Surgical Oncology
Dominique Grunenwald, MD, PhD
Aurora, Colorado, USA Ada Distinguished Professor of Thoracic
Professor
Oncology
Stefano Gasparini, MD, FCCP University of Paris
Program Leader Thoracic Oncology
Head Respiratory Diseases Unit Paris, France
UCSF Helen Diller Family
Department of Byomedic Sciences and
Matthias Guckenberger, MD Comprehensive Cancer Center
Public Health
Department of Radiation Oncology San Francisco, California, USA
Polytechnic University of Marche Region
University Hospital Zurich
Pulmonary Diseases Unit James R. Jett, MD
Zurich, Switzerland
Azienda Ospedali Riuniti Professor Emeritus
Ancona, Italy Swati Gulati, MD Department of Medicine
Division of Pulmonary Allergy and Division of Oncology
Adi F. Gazdar, MD
Critical Care Medicine Cancer Center
Professor
University of Alabama at Birmingham National Jewish Medical Center
Hamon Center for Therapeutic
Birmingham, Alabama, USA Denver, Colorado, USA
Oncology Research and Department of
Pathology Raffit Hassan, MD Andrew Kaufman, MD
The University of Texas Southwestern Senior Investigator Assistant Professor
Medical Center National Cancer Institute Department of Thoracic Surgery
Houston, Texas, USA National Institutes of Health Mount Sinai Medical Center
Bethesda, Maryland, USA New York, New York, USA
Giuseppe Giaccone, MD, PhD
Professor of Medical Oncology and Christopher Hazzard, MD Paul Keall, PhD
Pharmacology Department of Thoracic Surgery Professor
Associate Director for Clinical Research Icahn School of Medicine at Mount Sinai Radiation Physics
Georgetown University New York, New York, USA The University of Sydney
Lombardi Comprehensive Cancer Center Sydney, Australia
Fiona Hegi, MBBS, FRANZCR
Washington, DC, USA
Radiation Oncologist Karen Kelly, MD
Nicolas Girard, MD, PhD Radiation Physics Laboratory Professor
Professor The University of Sydney Division of Hematology and Oncology
Respiratory Medicine Service Sydney, Australia UC Davis Comprehensive Cancer Center
Hospices Civils de Lyon Sacramento, California, USA
Thomas Hensing, MD
Claude Bernard Lyon 1 University
Clinical Associate Professor Feng-Ming (Spring) Kong, MD, PhD
Lyon, France
University of Chicago Professor of Radiation Oncology and
Thorax Institute Curie Montsouris
NorthShore University HealthSystem Medical and Molecular Genetics
Curie Institute
Kellogg Cancer Center Director of Clinical Research/Clinical
Paris, France
Evanston, Illinois, USA Trials
Peter Goldstraw, MD, FRCS Radiation Oncology
Roy Herbst, MD, PhD
Emeritus Professor Co-Leader of Thoracic Oncology
Ensign Professor of Medicine (Medical
Academic Department of Thoracic Surgery Program
Oncology) and Professor of
Royal Brompton Hospital IU Simon Cancer Center
Pharmacology
Imperial College London Indiana University School of Medicine
Chief of Medical Oncology
London, United Kingdom Indianapolis, Indiana, USA
Yale Cancer Center and Smilow Cancer
Elizabeth M. Gore, MD Hospital Kaoru Kubota, MD
Professor of Radiation Oncology New Haven, Connecticut, USA Department of Pulmonary Medicine and
Department of Radiation Oncology Oncology
Fred R. Hirsch, MD, PhD
Medical College of Wisconsin Graduate School of Medicine
Professor
The Zablocki VA Medical Center Nippon Medical School
Professor of Medicine and Pathology
Milwaukee, Wisconsin, USA Tokyo, Japan
Department of Medicine
Glenwood Goss, MD, FCP(SA), FRCPC Department of Pathology Ite A. Laird-Offringa, PhD
Professor of Medicine, University of Ottawa University of Colorado Cancer Center Associate Professor
Director of Clinical Research Aurora, Colorado, USA Department of Surgery
The Ottawa Hospital Cancer Centre Department of Biochemistry and
Nanda Horeweg, MD
Chair Molecular Biology
Junior Researcher
Thoracic Oncology Site Committee USC/Norris Cancer Center
Erasmus University Medical Center
Canadian Cancer Trials Group Keck School of Medicine of USC
Department of Public Health
Ottawa, Canada Los Angeles, California, USA
Department of Pulmonary Diseases
Ramaswamy Govindan, MD Erasmus University Medical Center Primo N. Lara, Jr, MD
Professor Rotterdam, The Netherlands Professor of Medicine
Department of Medicine University of California, Davis
Division of Oncology School of Medicine
Washington University School of Acting Director
Medicine UC Davis Comprehensive Cancer Center
St. Louis, Missouri, USA Sacramento, California, USA
viii CONTRIBUTORS
Janessa Laskin, MD, FRCPC William J. Mackillop, MB, ChB, FRCR, Annette McWilliams, MBBS, FRACP,
Associate Professor FRCPC MD, FRCPC
Department of Medicine Professor Fiona Stanley Hospital
Division of Medical Oncology Departments of Oncology and Public Department of Respiratory Medicine
British Columbia Cancer Agency Health Sciences University of Western Australia
Vancouver, British Columbia, Canada Division of Cancer Care and Murdoch, Australia
Epidemiology
Quynh-Thu Le, MD, FACR, FASTRO Tetsuya Mitsudomi, MD, PhD
Queen’s Cancer Research Institute
Professor and Chair Professor
Queen’s University
Department of Radiation Oncology Division of Thoracic Surgery
Kingston, Canada
Stanford University Department of Surgery
Stanford, California, USA Christopher Maher, PhD Kinki University Faculty of Medicine
Assistant Professor Osaka-Sayama, Japan
Cécile Le Péchoux, MD
Department of Medicine
Gustave Roussy, Hopital Universitaire Tony Mok, MD
Division of Oncology
Radiation Oncology Department Professor
Washington University School of
Villejuif, France Department of Clinical Oncology
Medicine
The Chinese University of Hong Kong
Elvira L. Liclican, PhD St. Louis, Missouri, USA
Hong Kong, China
Scientific Officer
Isa Mambetsariev
UCLA Clinical and Translational Daniel Morgensztern, MD
Research Assistant
Science Institute Associate Professor
Department of Medical Oncology and
Los Angeles, California, USA Department of Medicine
Molecular Therapeutics
Division of Oncology
Yolande Lievens, MD, PhD City of Hope Comprehensive Cancer
Washington University School of Medicine
Associate Professor Center and Beckman Research
St. Louis, Missouri, USA
Radiation Oncology Department Institute
Ghent University Hospital Duarte, California, USA Francoise Mornex, MD, PhD
Ghent University Université Claude Bernard, Lyon1, EMR
Sumithra J. Mandrekar, PhD
Ghent, Belgium 3738, Department de Radiotherapie
Professor of Biostatistics and Oncology
CHU Lyon, France
Chia-Chi (Josh) Lin, MD, PhD Division of Biomedical Statistics and
Clinical Associate Professor Informatics James L. Mulshine, MD
Department of Oncology Mayo Clinic Dean
National Taiwan University Hospital Rochester, Minnesota, USA Graduate College (Acting)
Taipei, Taiwan Vice President
Aaron S. Mansfield, MD
Rush University
Billy W. Loo, Jr., MD, PhD Assistant Professor
Chicago, Illinois, USA
Associate Professor Medical Oncology
Radiation Oncology – Radiation Therapy Mayo Clinic Reginald F. Munden, MD, DMD, MBA
Stanford Cancer Institute Rochester, Minnesota, USA Professor and Chair
Stanford University Department of Radiology
Lawrence B. Marks, MD
Stanford, California, USA Wake Forest School of Medicine
Dr. Sidney K. Simon Distinguished
Winston-Salem, North Carolina, USA
Michael Mac Manus, MB, BCh, BAO, Professor of Oncology Research
MD, MRCP, FRANZCR Chairman Kristiaan Nackaerts, MD, PhD
Professor Department of Radiation Oncology Associate Professor
The Sir Peter MacCallum Department of University of North Carolina Department of Pulmonology/Respiratory
Oncology Lineberger Comprehensive Cancer Oncology
Peter MacCallum Cancer Centre Center University Hospital Gasthuisberg
The University of Melbourne Chapel Hill, North Carolina, USA Leuven, Belgium
Melbourne, Australia
Céline Mascaux, MD, PhD Shinji Nakamichi, MD
Homer A. Macapinlac, MD Associate Professor Department of Pulmonary Medicine and
Professor Assistance Publique Hôpitaux de Oncology
Department of Nuclear Medicine Marseille Graduate School of Medicine
Division of Diagnostic Imaging Oncologie Multidisciplinaire et Nippon Medical School
The University of Texas MD Anderson Innovations Thérapeutiques Tokyo, Japan
Cancer Center Aix Marseille University
Masayuki Noguchi, MD, PhD
Houston, Texas, USA Marseille, France
Professor
Fergus Macbeth, MA, DM, FRCR, Pierre P. Massion, MD Department of Pathology
FRCP, MBA Professor University of Tsukuba
Professor Thoracic Program at the Vanderbilt Tsukuba, Japan
Wales Cancer Trials Unit Ingram Cancer Center
Krista Noonan, MD, FRCPC
School of Medicine Vanderbilt University School of Medicine
Medical Oncologist
Cardiff University Nashville, Tennessee, USA
Division of Medical Oncology
Cardiff, United Kingdom
Julien Mazieres, MD, PhD British Columbia Cancer Agency
Professor Surrey, British Columbia, Canada
Toulouse University Hospital Clinical Assistant Professor
Universite Paul Sabatier University of British Columbia
Toulouse, France Vancouver, British Columbia, Canada
CONTRIBUTORS ix
Silvia Novello, MD, PhD Nicholas Pastis, MD, FCCP Mary W. Redman, PhD
Full Professor of Medical Oncology Associate Professor of Medicine Associate Member
Thoracic Oncology Unit Fellowship Program Director Clinical Biostatistics
San Luigi Hospital Division of Pulmonary and Critical Care Clinical Research Division
University of Turin Medical University of South Carolina Lead Statistician
Orbassano, Turin, Italy Charleston, South Carolina, USA SWOG Lung Committee
Fred Hutchinson Cancer Research Center
Anna K. Nowak, MBBS, FRACP, PhD Luis Paz-Ares, MD, PhD
Seattle, Washington, USA
Professor Head of Medical Oncology Department
School of Medicine University Hospital Doce de Octubre Niels Reinmuth, MD, PhD
University of Western Australia Professor Professor
Crawley, Australia Complutense University, Medicine Department of Thoracic Oncology
Campus Lungen Clinic Grosshansdorf
Kenneth J. O’Byrne, MD
Madrid, Spain Member of German Center for Lung
Professor, Medical Oncology
Research (DZL)
Princess Alexandra Hospital Nathan Pennell, MD, PhD
Grosshansdorf, Germany
Queensland University of Technology Associate Professor
Queensland, Australia Department of Hematology and Medical Umberto Ricardi, MD
Oncology Full Professor Radiation Oncology
Nisha Ohri, MD
Cleveland Clinic Taussig Cancer Department of Oncology
Department of Radiation Oncology
Institute University of Turin
Mount Sinai Hospital
Cleveland, Ohio, USA Turin, Italy
New York, New York, USA
Maurice Perol David Rice, MD
Morihito Okada, MD, PhD
Centre Leon Berard Professor
Department of Surgical Oncology
Department of Medical Oncology Department of Thoracic and
Research Institute for Radiation Biology
Lyon, France Cardiovascular Surgery
and Medicine
The University of Texas MD Anderson
Hiroshima University Rathi N. Pillai, MD
Cancer Center
Hiroshima, Japan Assistant Professor
Houston, Texas, USA
Department of Hematology and
Jamie S. Ostroff, PhD
Oncology Carole A. Ridge, FFRRCSI
Professor and Chief, Behavioral Sciences
Winship Cancer Institute Consultant Radiologist
Service
Emory University Department of Radiology
Department of Psychiatry and Behavioral
Atlanta, Georgia, USA Mater Misericordiae University Hospital
Sciences
Dublin, Ireland
Memorial Sloan Kettering Cancer Center Pieter E. Postmus, MD
New York, New York, USA Professor of Thoracic Oncology William N. Rom, MD, MPH
Clatterbridge Cancer Centre Professor
Mamta Parikh, MD
Liverpool Heart and Chest Hospital Division of Pulmonary, Critical Care,
University of California, Davis
University of Liverpool, United Kingdom and Sleep Medicine
School of Medicine
Department of Medicine
Sacramento, California, USA Suresh S. Ramalingham, MD
Department of Environmental Medicine
Professor of Hematology and Medical
Elyse R. Park, PhD New York University School of Medicine
Oncology
Associate Professor New York University College of Global
Roberto C. Goizueta Chair for Cancer
Psychiatry and Mongan Institute for Public Health
Research
Health Policy New York, New York, USA
Deputy Director
Harvard Medical School
Winship Cancer Institute Kenneth E. Rosenzweig, MD, FASTRO,
Massachusetts General Hospital
Emory University School of Medicine FACR
Boston, Massachusetts, USA
Atlanta, Georgia, USA Professor and Chairman
Keunchil Park, MD, PhD Department of Radiation Oncology
Sara Ramella, MD
Professor Icahn School of Medicine at Mount Sinai
Associate Professor
Division of Hematology/Oncology New York, New York, USA
Radiation Oncology Department
Department of Medicine
Campus Bio-Medico University Enrico Ruffini, MD
Samsung Medical Center
Rome, Italy Associate Professor
Sungkyunkwan University School of
Section of Thoracic Surgery
Medicine Ramón Rami-Porta, MD, PhD, FETCS
Department of Surgery
Seoul, Korea Attending Thoracic Surgeon
University of Turin
Department of Thoracic Surgery
Harvey I. Pass, MD Turin, Italy
Hospital Universitari Mutua Terrassa
Stephen E. Banner Professor of Thoracic
University of Barcelona and CIBERES Valerie W. Rusch, MD, FACS
Oncology
Lung Cancer Group Attending Surgeon
Vice-Chairman of Research
Terrassa, Barcelona, Spain Thoracic Service
Department of Cardiothoracic Surgery
Vice Chair
New York University Langone Medical Martin Reck, MD, PhD
Clinical Research
Center Professor
Department of Surgery
New York, New York, USA Department of Thoracic Oncology and
Miner Family Chair in Intrathoracic
Department of Clinical Trials
Cancers
Lungen Clinic Grosshansdorf
Memorial Sloan Kettering Cancer Center
Grosshansdorf, Germany
New York, New York, USA
x CONTRIBUTORS
Ravi Salgia, MD, PhD Gerard A. Silvestri, MD, MS, FCCP Ming-Sound Tsao, MD, FRCPC
Professor and Chair Professor Professor
Associate Director for Clinical Sciences Vice Chair of Medicine for Faculty Department of Laboratory Medicine and
Department of Medical Oncology and Development Pathobiology
Therapeutics Research Division of Pulmonary and Critical Care Department of Medical Biophysics
City of Hope Comprehensive Cancer Medical University of South Carolina University of Toronto
Center Charleston, South Carolina, USA Consultant Pathologist
Duarte, California, USA University Health Network
George R. Simon, MD
Princess Margaret Cancer Centre
Montse Sanchez-Cespedes, PhD Professor
Toronto, Ontario, Canada
Head of the Genes and Cancer Department of Thoracic/Head and Neck
Laboratory Medical Oncology Jun-Chieh J. Tsay, MD, MSc
Cancer Epigenetics and Biology Program The University of Texas MD Anderson Assistant Professor
Bellvitge Biomedical Research Institute- Cancer Center Division of Pulmonary, Critical Care,
IDIBELL Houston, Texas, USA and Sleep Medicine
Hospital Duran i Reynals Department of Medicine
Egbert F. Smit, MD, PhD
Barcelona, Spain New York University School of Medicine
Professor
New York, New York, USA
Anjali Saqi, MD, MBA Department of Pulmonary Diseases
Professor Vrije Universiteit VU Medical Centre Paul Van Houtte, MD, PhD
Department of Pathology and Cell and Department of Thoracic Oncology Professor Emeritus
Biology Netherlands Cancer Institute Department of Radiation Oncology
Columbia University Medical Center Amsterdam, The Netherlands Institut Jules Bordet
New York, New York, USA Université Libre Bruxelles
Stephen B. Solomon, MD
Brussels, Belgium
Giorgio V. Scagliotti, MD, PhD Chief
Professor of Medical Oncology Interventional Radiology Service Paul E. Van Schil, MD, PhD
Head of Department of Oncology at Department of Radiology Chair
San Luigi Hospital Memorial Sloan Kettering Cancer Center Department of Thoracic and Vascular
University of Turin New York, New York, USA Surgery
Orbassano, Turin, Italy Antwerp University Hospital
Laura P. Stabile, PhD
Edegem, Belgium
Selma Schimmel† Research Associate Professor
Founder Department of Pharmacology and Nico van Zandwijk, MD, PhD, FRACP
Vital Options International, Inc Chemical Biology Professor University of Sydney
Studio City, California, USA University of Pittsburgh Director Asbestos Diseases Research
Pittsburgh, Pennsylvania, USA Institute
Ann G. Schwartz, PhD, MPH
Rhodes, Australia
Deputy Center Director and Professor Matthew A. Steliga, MD
Department of Oncology Associate Professor of Surgery J. F. Vansteenkiste, MD, PhD
Karmanos Cancer Institute Division of Cardiothoracic Surgery Professor Internal Medicine
Wayne State University University of Arkansas for Medical Respiratory Oncology Unit (Department
Detroit, Michigan, USA Sciences of Respiratory Medicine)
Little Rock, Arkansas, USA University Hospital KU Leuven
Suresh Senan, MRCP, FRCR, PhD
Leuven, Belgium
Professor of Clinical Experimental Thomas E. Stinchcombe, MD
Radiotherapy Duke Cancer Institute Marileila Varella-Garcia, PhD
Department of Radiation Oncology Durham, North Carolina, USA Professor
VU University Medical Center Department of Medicine
Nicholas S. Stollenwerk, MD
Amsterdam, The Netherlands Division of Medical Oncology
Associate Clinical Professor
University of Colorado Anschutz Medical
Francis A. Shepherd, MD, FRCPC UC Davis Comprehensive Cancer Center
Campus
Professor of Medicine VA Northern California Health Care
Aurora, Colorado, USA
University of Toronto System
Scott Taylor Chair in Lung Cancer Sacramento, California, USA Giulia Veronesi, MD
Research Division of Thoracic Surgery
Jong-Mu Sun, MD, PhD
Department of Medical Oncology and Director of Robotic Thoracic Surgery
Clinical Assistant Professor
Hematology Humanitas Research Hospital
Division of Hematology/Oncology
University Health Network Rozzano, Italy
Samsung Medical Center
Princess Margaret Cancer Centre
Sungkyunkwan University School of Shalini K. Vinod, MBBS, MD, FRANZCR
Toronto, Ontario, Canada
Medicine Associate Professor
Jill M. Siegfried, PhD Seoul, Korea Cancer Therapy Centre
Professor and Head Liverpool Hospital
Anish Thomas, MD
Department of Pharmacology Sydney, Australia
Developmental Therapeutics Branch
Frederick and Alice Stark Endowed Chair
National Cancer Institute Everett E. Vokes, MD
Associate Director for Translation
National Institutes of Health John E. Ultmann Professor
Masonic Cancer Center
Bethesda, Maryland, USA Chairman
University of Minnesota
Department of Medicine
Minneapolis, Minnesota, USA
Physician-in-Chief
University of Chicago Medicine and
Biologic Sciences
† Deceased. Chicago, Illinois, USA
CONTRIBUTORS xi
Heather Wakelee, MD Ignacio I. Wistuba, MD Ken Y. Yoneda, MD
Associate Professor of Medicine Professor Professor
Division of Oncology Chair Clinical Internal Medicine
Stanford Cancer Institute Department of Translational Molecular UC Davis Comprehensive Cancer Center
Stanford, California, USA Pathology VA Northern California Health Care
Anderson Clinical Faculty Chair for System
Tonya C. Walser, PhD
Cancer Treatment and Research Sacramento, California, USA
Assistant Professor
The University of Texas MD Anderson
Division of Pulmonary and Critical Care Gérard Zalcman, MD, PhD
Cancer Center
Medicine CHU Caen
Houston, Texas, USA
David Geffen School of Medicine at UCLA Interne des Hopitaux de Paris
Los Angeles, California, USA James Chih-Hsin Yang, MD, PhD Ile-de-France, France
Professor and Director
Shun-ichi Watanabe, MD Caicun Zhou, MD, PhD
Graduate Institute of Oncology
Department of Thoracic Surgery Professor
College of Medicine
National Cancer Center Hospital Shanghai Pulmonary Hospital
National Taiwan University
Tokyo, Japan Tongji University
Director
Shanghai, China
Walter Weder, MD Department of Oncology
Professor National Taiwan University Hospital Yang Zhou, PhD, MPH
Department of Thoracic Surgery Taipei, Taiwan Program Manager
University Hospital Yale Comprehensive Cancer Center
David F. Yankelevitz, MD
Zurich, Switzerland Yale School of Medicine
Professor
New Haven, Connecticut, USA
Benjamin Wei, MD Department of Radiology
Assistant Professor Mount Sinai Medical Center Daniel Zips, MD
Section of Thoracic Surgery Mount Sinai Hospital Chair
Division of Cardiothoracic Surgery New York, New York, USA Professor Radiation Oncology
Department of Surgery Director
Kazuhiro Yasufuku, MD, PhD
University of Alabama-Birmingham CCC Tübingen-Stuttgart
Director of Endoscopy
Medical Center University Hospital Tübingen
University Health Network
Birmingham, Alabama, USA University Department of Radiation
Director
Oncology
Interventional Thoracic Surgery Program
Tübingen, Germany
Division of Thoracic Surgery
Toronto General Hospital
University Health Network
Toronto, Ontario, Canada
