Hepatitis C protocols

1268 Pages·1998·6.89 MB·English

by  Johnson Yiu-Nam Lau

Hepatitis C Protocols Methods in Molecular
title:
Medicine ; 19
author: Lau, Johnson Y. N.
publisher: Humana Press
isbn10 | asin: 0896035212
print isbn13: 9780896035218
ebook isbn13: 9780585235653
language: English
Hepatitis C virus--Research--Methodology,
Hepatitis C--diagnosis, Hepatitis C--
subject
genetics, Hepatitis C Antibodies, Hepatitis
C Antigens.
publication date: 1998
lcc: QR201.H46H447 1998eb
ddc: 616.3/623
Hepatitis C virus--Research--Methodology,
subject: Hepatitis C--diagnosis, Hepatitis C--
genetics, Hepatitis C Antibodies, Hepatitis
C Antigens.
Page i
Hepatitis C Protocols
Page ii
METHODS IN MOLECULAR MEDICINE
John M. Walker, S E
ERIES DITOR
19. Hepatitis C Protocols, edited by Johnson Yiu-Nam Lau, 1998
18. Tissue Engineering, edited by Jeffrey R. Morgan and Martin L.
Yarmush, 1998
17. HIV Protocols, edited by Nelson Michael and Jerome H. Kim,
1998
16. Clinical Applications of PCR, edited by Y. M. Dennis Lo, 1998
15. Molecular Bacteriology: Protocols and Clinical Applications,
edited by Neil Woodford and Alan Johnson, 1998
14. Tumor Marker Protocols, edited by Margaret Hanausek and
Zbigniew Walaszek, 1998
13. Molecular Diagnosis of Infectious Diseases, edited by Udo
Reischl, 1998
12. Diagnostic Virology Protocols, edited by John R. Stephenson and
Alan Warnes, 1998
11. Therapeutic Application of Ribozymes, edited by Kevin J.
Scanlon, 1998
10. Herpes Simplex Virus Protocols, edited by S. Moira Brown and
Alasdair MacLean, 1998
9. Lectin Methods and Protocols, edited by Jonathan M. Rhodes and
Jeremy D. Milton, 1998
8. Helicobacter pylori Protocols, edited by Christopher L. Clayton
and Harry L. T. Mobley, 1997
7. Gene Therapy Protocols, edited by Paul D. Robbins, 1997
6. Molecular Diagnosis of Cancer, edited by Finbarr Cotter, 1996
5. Molecular Diagnosis of Genetic Diseases, edited by Rob Elles,
1996
4. Vaccine Protocols, edited by Andrew Robinson, Graham H. Farrar,
and Christopher N. Wiblin, 1996
3. Prion Diseases, edited by Harry F. Baker and Rosalind M. Ridley,
1996
2. Human Cell Culture Protocols, edited by Gareth E. Jones, 1996
1. Antisense Therapeutics, edited by Sudhir Agrawal, 1996
Page iii
METHODS IN MOLECULAR MEDICINE
Hepatitis C Protocols
Edited by
Johnson Yiu-Nam Lau, MD
Schering-Plough Research Institute, Kenilworth, NJ
Forewords by
T. Jake Liang
Gary L. Davis
Michael Houghton, Q. L. Choo, and George Kuo
Humana Press
Totowa, New Jersey
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Library of Congress Cataloging in Publication Data
Main entry under title:
Methods in molecular medicine.
Hepatitis C protocols/edited by Johnson Y. N. Lau; forewords by Q. L. Choo, Gary L. Davis, Michael
Houghton, George Kuo, T. Jake Liang.
p. cm.(Methods in molecular medicine; 19)
Includes index.
ISBN 0-89603-521-2 (alk. paper)
I. Hepatitis C virusResearchMethodology. I. Lau, Johnson Y. N. (Johnson Yiu-Nam) II.
Series.
[DNLM: 1. Hepatitis Cdiagnosis. 2. Hepatitis Cgenetics. 3. Hepatitis C Antibodies. 4. Hepa-
titis C Antigens. WC 536 H53363 1998]
QR201.H46H447 1998
616.3'623dc21
DNLM/DLC
for Library of Congress 98-24896
CIP
Page v
FOREWORD
The identification of hepatitis C virus by Michael Houghton and his
colleagues at the Chiron Corporation nearly 10 years ago represented
a technical tour de force of modern molecular medicine. This
breakthrough not only unearthed the causative agent of non-A non-B
hepatitis that had eluded the best of scientists for more than 20 years,
but also was symbolic of another chapter in the changing paradigm of
modern science and medicine. The revolutionary concept of
identifying a pathogen without actually visualizing or detecting it will
forever redefine the way we approach pathogenesis of diseases whose
cause is unknown. It is benefitting that this discovery treads on the
heels of the human immunodeficiency pandemic, and parallels the
alarming emergence of various microbial pestilences in the world.
Despite the rapid advances in our understanding of the virus, there is
much remaining to learn about it. This book highlights some of the
important areas yet to be unraveled. As illustrated in this book, the
marriage between basic science and clinical medicine is essential in
our quest for these unknowns. The last decade has focused on the
fundamentals of the virus; the next decade must underscore
translational research, bridging clinical medicine and basic science
with realization of fundamental knowledge to improve prevention,
diagnosis, and treatment of viral hepatitis C. Undoubtedly in the next
millenium, we will develop a much better strategy to combat this virus
and have a much brighter outlook on the disease for the millions of
people infected with the virus.
T. JAKE LIANG
LIVER DISEASES SECTION
NATIONAL INSTITUTE OF DIABETES AND
DIGESTIVE AND KIDNEY DISEASES
NATIONAL INSTITUTES OF HEALTH
BETHESDA, MD