Genitourinary

1070 Pages·2016·45.58 MB·English

by  Mahul B. Amin

SECOND EDITION

AMIN | TICKOO
MCKENNEY • PANER • SHEN • SMITH • AL-AHMADIE
VELAZQUEZ • CUBILLA • RO • REUTER
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SECOND EDITION
Mahul B. Amin, MD
Professor and Chairman Emeritus,
Pathology and Laboratory Medicine
Cedars-Sinai Medical Center
Professor of Pathology and Laboratory Medicine
UCLA David Geffen School of Medicine
Visiting Professor, Urology
USC Keck School of Medicine
Los Angeles, California
Visiting Professor, Pathology and Immunology
Baylor College of Medicine
Houston, Texas
Satish K. Tickoo, MD
Attending Pathologist
Department of Pathology
Memorial Sloan Kettering Cancer Center
New York, New York
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1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
DIAGNOSTIC PATHOLOGY: GENITOURINARY, SECOND EDITION ISBN: 978-0-323-37714-0
Copyright © 2016 by Elsevier. All rights reserved.
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This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be
noted herein).
Notices

Knowledge and best practice in this field are constantly changing. As new research and
experience broaden our understanding, changes in research methods, professional practices,
or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in
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take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or
editors, assume any liability for any injury and/or damage to persons or property as a matter
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products, instructions, or ideas contained in the material herein.
Publisher Cataloging-in-Publication Data
Names: Amin, Mahul B. | Tickoo, Satish K.
Title: Diagnostic pathology. Genitourinary / [edited by] Mahul B. Amin and Satish K. Tickoo.
Other titles: Genitourinary.
Description: Second edition. | Salt Lake City, UT : Elsevier, Inc., [2016] | Includes bibliographical
references and index.
Identifiers: ISBN 978-0-323-37714-0
Subjects: LCSH: Genitourinary organs--Diseases--Diagnosis--Handbooks, manuals, etc. | MESH: Male
Urogenital Diseases--diagnosis--Atlases. | Male Urogenital Diseases--pathology--Atlases. |
Kidney Neoplasms--diagnosis--Atlases. | Kidney Neoplasms--pathology--Atlases.
Classification: LCC RC874.D52 2016 | NLM WJ 17 | DDC 616.6’075--dc23
International Standard Book Number: 978-0-323-37714-0
Cover Designer: Tom M. Olson, BA
Printed in Canada by Friesens, Altona, Manitoba, Canada
Last digit is the print number: 9 8 7 6 5 4 3 2 1
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Dedications
To my wonderful family, Ushma, Anmol, and Aneri, for their everlasting warmth,
love, and support; my late parents, who constantly motivated and inspired me
to excel and serve; my residents and fellows, who support and challenge me to
push the envelope of urologic pathology; my consultees, for sharing their difficult
cases, which serve as a nidus for my educational and research efforts; my clinical
and scientific colleagues, urologists, oncologists, and radiation oncologists, who
constantly push me to try to be a better surgical pathologist; and my patients,
who continually help engage me in a process of life-long learning and serve as a
vivid and constant reminder that there is a lot more to be done for them.
Acknowledgments
I gratefully acknowledge the assistance of the visiting physician scholars to
Cedars-Sinai (Dr. Ghee Yong Kwon, Korea; Dr. Nalan Nese, Turkey; and Dr. Anniah
Chandrakanth, Canada) for going through my teaching files and helping to obtain
innumerable pictures for this book, and the assistance of Dolores Ramirez, my
Executive Administrative Assistant, for her efficient project management that
kept this large initiative on track.
MBA
To my mother.
SKT
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Contributing Authors
Jesse K. McKenney, MD Jae Y. Ro, MD, PhD
Section Head, Surgical Pathology Director, Surgical Pathology
Cleveland Clinic Department of Pathology and Genomic Medicine
Cleveland, Ohio Houston Methodist Hospital
Professor of Pathology and Laboratory Medicine
Weill Medical College of Cornell University
Gladell P. Paner, MD
Houston, Texas
Associate Professor
Departments of Pathology and
Surgery Section of Urology Victor E. Reuter, MD
University of Chicago Medical Center Vice-Chairman
Chicago, Illinois Department of Pathology
Memorial Sloan Kettering Cancer Center
New York, New York
Steven S. Shen, MD, PhD
Associate Director, Surgical Pathology
Houston Methodist Hospital Diego Fernando Sánchez Martínez, MD
Professor of Pathology and Laboratory Medicine Pathology Researcher
Weill Medical College of Cornell University Instituto de Patología e Investigación
Houston, Texas School of Medicine, Universidad Nacional de Asunción
Asunción, Paraguay
Steven Christopher Smith, MD, PhD
Assistant Director, Surgical Pathology Maria José Fernández De Nestosa, PhD
Department of Pathology
Research Professor
VCU Health System
Scientific and Applied Computing Laboratory
Richmond, Virginia
Facultad Politécnica, Universidad Nacional de Asunción
Asunción, Paraguay
Hikmat Al-Ahmadie, MD
Assistant Attending Sofía Cañete Portillo, MD
Department of Pathology
Research Collaborator
Memorial Sloan Kettering Cancer Center
Instituto de Patología e Investigación
New York, New York
Asunción, Paraguay
Pathology Resident
Elsa F. Velazquez, MD Department of Surgical Pathology
Director of Dermatopathology Instituto de Previsión Social
Miraca Life Sciences Asunción, Paraguay
Tufts University School of Medicine
Boston, Massachusetts
Deepika Sirohi, MD
Clinical Fellow, Genitourinary Pathology
Antonio L. Cubilla, MD Department of Pathology and Laboratory Medicine
Director Cedars-Sinai Medical Center
Instituto de Patología e Investigación Los Angeles, California
Emeritus Professor
School of Medicine, Universidad Nacional de Asunción
Asunción, Paraguay
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Chisato Ohe, MD
Visiting Postdoctoral Scientist
Department of Pathology and Laboratory Medicine
Cedars-Sinai Medical Center
Los Angeles, California
Mukul K. Divatia, MD
Staff Pathologist
Department of Pathology and Genomic Medicine
Houston Methodist Hospital
Houston, Texas
Judy Sarungbam, MD
Genitourinary Pathology Fellow
Department of Pathology
Memorial Sloan Kettering Cancer Center
New York, New York
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Preface
There could not be a more exciting time to publish the second edition of Diagnostic Pathology:
Genitourinary. The subspecialty of genitourinary pathology (also called urologic pathology)
continues to generate great clinical and academic interest, which results in a continued
expansion in the knowledge base around entities encompassed within it. The World
Health Organization (WHO) has just published the fourth edition of the WHO Classification
of Tumours of the Urinary System and Male Genital Organs, and the nomenclature and
classifications promulgated through this publication are largely consistent with this offering.
Further, in recent years, the International Society of Urological Pathologists (ISUP) has been
very active in publishing best practices and consensus and position statements. This book
incorporates the approach promoted through these publications.
The second edition of Diagnostic Pathology: Genitourinary is therefore a considerably updated
and revised edition, and through the authoring process, all authors have attempted five
important goals. First, maintain the core goal established in the first edition of being a
succinct, user-friendly, “one-stop” diagnostic compendium for the busy practicing pathologist
as well as residents and fellows in training. The combination of pithy, factual, bulleted text
along with rich and diverse illustrations is intended to help the pathologist arrive at the correct
diagnosis, consider key differential diagnostic possibilities, and employ contemporary and
judicious ancillary studies as appropriate, with reporting guidelines that enable generation
of a complete and accurate surgical pathology report. Second, our very experienced author
group, like other prominent academicians, travel and lecture frequently both within the
United States and internationally. Our readers have been generous with compliments of the
value of the book and importantly, during these educational forums, have provided feedback
for improvement and refinement. We have incorporated their suggestions by including
concurrent illustrations of a wide range of differential diagnoses, making our figure legends
more didactic, educational, and practical, and emphasizing practical aspects about staging
and assessment of prognostic factors. Third, we have updated the text in a manner reflecting
the current understanding of the diseases in terms of diagnosis, prognosis, and approach to
management. Fourth, we have added entirely new sections and chapters on recent entities or
those previously not covered in the first edition. For example, new sections on the renal pelvis,
ureter, urethra, urachus, and diverticular bladder disease, each with chapters within them,
are added. Examples of new entities in the kidney include transcription elongation factor B
(TCEB1)-mutated renal cell carcinoma and renal cell carcinomas occurring in the succinate
dehydrogenase complex deficiency syndrome. In the bladder section, a new chapter on
inverted neoplasms is included along with the aforementioned new sections. Other examples
of new chapters include one on regressed (burnt-out) germ cell tumors of the testis and
chapters on newer variants of penile cancer, including lymphoepithelioma-like and clear cell
carcinoma. Finally, we have incorporated not only important advances in the literature, but
also updated the book with recommendations from the ISUP and the WHO.
The overall organization of the book in terms of the five sections, Kidney Tumors and Tumor-
Like Conditions, Urinary Bladder, Prostate Gland and Seminal Vesicles, Testis and Paratesticular
Structures, and Penis and Scrotum, is maintained. The authors within the teams responsible
for each section are very experienced, and, apart from drawing on their own clinical
experiences, the entire authorship shared ideas, approaches, concepts, and classic teaching
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cases through face-to-face and phone discussions and e-mails to produce a synergistic
offering. We, the editors, were additionally heavily involved over these attempts for
consistency, easy readability, and practicality within each chapter at every level, from the
text, tables, and illustrations to the didactic figure legends.
We hope that in this refined, updated, and expanded offering of the second edition, you
continue to find value in the eBook version (available on the Expert Consult platform),
which is intended to add another level of desktop user-friendliness and utility beyond what
the hard copy of the book may bring. Finally, this second edition of content of Diagnostic
Pathology: Genitourinary will also be part of the exciting new product, ExpertPath, which
provides comprehensive decision support over all pathology sites searchable among other
things by entity, pathological features, or immunohistochemical findings.
Mahul B. Amin, MD
Professor and Chairman Emeritus, Pathology and Laboratory Medicine
Cedars-Sinai Medical Center
Professor of Pathology and Laboratory Medicine
UCLA David Geffen School of Medicine
Visiting Professor, Urology
USC Keck School of Medicine
Los Angeles, California
Visiting Professor, Pathology and Immunology
Baylor College of Medicine
Houston, Texas
Satish K. Tickoo, MD
Attending Pathologist
Department of Pathology
Memorial Sloan Kettering Cancer Center
New York, New York
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