Table Of ContentBertil Damato · Arun D. Singh
Editors
Clinical
Ophthalmic Oncology
Uveal Tumors
Second Edition
123
Clinical Ophthalmic Oncology
Bertil Damato (cid:129) Arun D. Singh
Editors
Clinical Ophthalmic
Oncology
Uveal Tumors
Second Edition
Editors
Bertil Damato, MD, PhD, FRCOphth Arun D. Singh, MD
Ocular Oncology Service Department of Ophthalmic Oncology
Departments of Ophthalmology and Cole Eye Institute Cleveland
Radiation Oncology Clinic Foundation
University of California Cleveland , OH
San Francisco, CA USA
USA
ISBN 978-3-642-54254-1 ISBN 978-3-642-54255-8 (eBook)
DOI 10.1007/978-3-642-54255-8
Springer Heidelberg New York Dordrecht London
Library of Congress Control Number: 2014938987
© Springer-Verlag Berlin Heidelberg 2014
First edition originally published by © Saunders, 2007
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Pref ace
Th e management of patients with an ophthalmic tumor presents particular
challenges. Ophthalmic tumors are rare and diverse so that their diagnosis
can be quite complex. Treatment usually requires special expertise and equip-
ment and in many instances is controversial. Th e fi eld is advancing rapidly,
because of accelerating progress in tumor biology, pharmacology, and instru-
mentation. Increasingly, the care of patients with an ocular or adnexal tumor
is provided by a multidisciplinary team, consisting of ocular oncologists,
g eneral oncologists, radiotherapists, pathologists, psychologists, and other
specialists. For all these reasons, we felt that there was a continued need for a
textbook of ophthalmic oncology, which would amalgamate knowledge from
several diff erent disciplines, thereby helping the various specialists to under-
stand each other better and to cooperate more effi ciently, eventually moving
ophthalmic oncology in the realm of evidence-based medicine.
As several important studies have been published in recent years, the purpose
of C linical Ophthalmic Oncology (2nd edition) is to provide up-to-date information
on the whole spectrum of the eyelid, conjunctival, intraocular, and orbital tumors
including basic principles of chemotherapy, radiation therapy, cancer epidemiol-
ogy, angiogenesis, and cancer genetics. Several chapters authored by radiation
oncologists, medical physicists, pediatric oncologists, hematologist-oncologists,
and medical geneticists have been included to provide a broader perspective.
Although each section of Clinical Ophthalmic Oncology now represents a
standalone volume, each chapter has a similar layout with boxes that high-
light the key features, tables that provide comparison, and fl ow diagrams that
outline therapeutic approaches. Each chapter has been edited (with author’s
approval) to present a balanced view of current clinical practice, and special
attention has been paid to make the text easily readable.
The authors followed a tight timeline to keep the contents of the book
c urrent. As we undertook this ambitious task of editing a multi-author, multi-
volume textbook, we were supported and guided by the staff at Springer:
Sverre Klemp, Ulrike Huesken, Ellen Blasig, and Prejith PremLal (from SPi).
It is our sincere hope that readers will fi nd as much pleasure reading this
volume as we had writing and editing it. If you fi nd Clinical Ophthalmic
Oncology informative, it is because (paraphrasing Isaac Newton) “we have
seen further, by standing on the shoulders of the giants.”
San Francisco, CA, USA Bertil Damato, MD, PhD, FRCOphth
Cleveland, OH, USA Arun D. Singh, MD
v
Acknowledgements
To my family, Frankanne, Erika, Stephen, Anna, Andreas and Cecilia. (BED)
To my parents who educated me beyond their means, my wife Annapurna,
and my children, Nakul and Rahul, who make all my eff orts worthwhile. (ADS)
vii
Contents
1 Examination Techniques. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Bertil Damato and Iwona Rospond-Kubiak
2 Classifi cation of Uveal Tumors. . . . . . . . . . . . . . . . . . . . . . . . . . 11
Bertil Damato and Sarah E. Coupland
3 Fine Needle Aspiration Biopsy . . . . . . . . . . . . . . . . . . . . . . . . . . 17
Arun D. Singh, Charles V. Biscotti, and David E. Pelayes
4 Miscellaneous Uveal Biopsy Techniques . . . . . . . . . . . . . . . . . . 31
Bertil Damato, Martina Angi, Sarah E. Coupland,
Heinrich Heimann, and Carl Groenewald
5 Benign Melanocytic Tumors of the Uvea. . . . . . . . . . . . . . . . . . 41
Miguel A. Materin and Arun D. Singh
6 Uveal Melanoma: Epidemiologic Aspects . . . . . . . . . . . . . . . . . 75
Nakul Singh, Louise Bergman, Stefan Seregard,
and Arun D. Singh
7 Uveal Melanoma: Clinical Features. . . . . . . . . . . . . . . . . . . . . . 89
Ann Schalenbourg and Leonidas Zografos
8 Uveal Melanoma: Differential Diagnosis. . . . . . . . . . . . . . . . . . 99
Devron H. Char
9 Uveal Malignant Melanoma: Histopathologic Features. . . . . . 113
Tero Kivelä
10 Molecular Pathology of Uveal Melanoma . . . . . . . . . . . . . . . . . 125
Sarah E. Coupland, Sarah L. Lake, and Bertil Damato
11 Iris Melanoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137
Arun D. Singh and Bertil Damato
12 Management of Patients with Posterior Uveal Melanoma. . . . 159
Bertil Damato
13 Uveal Malignant Melanoma: Management Options
for Brachytherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
Stefan Seregard and Bertil Damato
ix
