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Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry) PDF

161 Pages·1998·24.889 MB·English
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About Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry)

Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery.

Detailed Information

Author:Klaus Gubernator, Hans-Joachim Bohm, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman
Publication Year:1998
ISBN:9783527612161
Pages:161
Language:English
File Size:24.889
Format:PDF
Price:FREE
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