P olymeric P articulate Systems for Imm unotherapy of Cancer

163 Pages·2015·6.32 MB·English

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R
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n Sima Rahimian
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2015

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Polymeric Particulate Systems
for Immunotherapy of Cancer
The printing of this thesis was financially supported by
Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands
Polymeric Particulate Systems for Immunotherapy of Cancer
© 2015 Sima Rahimian
ISBN: 978-903-93-6371-3
Cover photo: Sima Rahimian
Cover design: Sima Rahimian and Tomas E. Coomans
Printed by CPI Koninklijke Wöhrmann Print Service
This research was supported by Center for Translational Molecular Medicine
(CTMM),Cancer Vaccine Tracking project (#03O-302).
Polymeric Particulate Systems for
Immunotherapy of Cancer
Polymere Deeltjessystemen voor Immunotherapie van Kanker
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht op
gezag van de rector magnificus, prof. dr. G.J. van der Zwaan, ingevolge het
besluit van het college voor promoties in het openbaar te verdedigen op
woensdag 8 juli 2015 des middags te 12.45 uur
door
Sima Rahimian
geboren op 21 september 1982
te Sari, Iran
Promotoren: Prof. dr. ir. W. E. Hennink
Prof. dr. F. A. Ossendorp
Copromotor: Dr. M. Amidi
To know and to die or not to know and to die?!
Aburayhan Biruni

Contents
Chapter 1 7
General Introduction
Chapter 2 15
Particulate systems based on poly(lactic-co-glycolic)acid (pLGA) for
immunotherapy of cancer
Chapter 3 43
Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on
a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of
antigen-specific CD8+ T cell immune response
Chapter 4 69
Polymeric nanoparticles for co-delivery of synthetic long peptide antigen
and poly IC as therapeutic cancer vaccine formulation
Chapter 5 87
Polymeric microparticles for sustained and local delivery of antiCD40 and
antiCTLA4 in immunotherapy of cancer
Chapter 6 107
Effect of particle size on internalization of pLHMGA particles by dendritic

cells: an introductory study
Chapter 7 123
Summary and Perspectives
Chapter 8 135
Appendices
Nederlandse Samenvatting
List of Publications
List of abbreviations
Affiliation of collaborating authors
Acknowledgments
Curriculum Vitae

CHAPTER 1
General Introduction