military medical academy

360 Pages·2010·4.55 MB·English

MEDICAL MANAGEMENT OF CHEMICAL AND BIOLOGICAL CASUALTIES

MILITARY MEDICAL ACADEMY

MMeeddiiccaall MMaannaaggeemmeenntt
ooff CChheemmiiccaall aanndd
BBiioollooggiiccaall CCaassuuaallttiieess

Edited by

Major-General Prof. Stoian Tonev, MD,PhD
Assoc. Prof. Kamen Kanev, MD,PhD, DSc
Prof. Christophor Dishovsky, MD, PhD, DSc

SOFIA 2009

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S. Tonev, K. Kanev, C. Dishovsky

© Stoian Tonev, Kamen Kanev and Christophor Dishovsky, 2009

All rights reserved. No reproduction, copy or transmission of this publi-
cation may be made without written permission from the authors.
Authors bear full responsibility for their articles presented in this publi-
cation.
Authors will not receive honoraria for their contributions.

First published in August 2009 by Publishing House IRITA

A catalogue record of this book is available from National Library
“St. St. Cyril and Methodius”, Sofia.

Stoian Tonev, Kamen Kanev and Christophor Dishovsky
Medical Management of Chemical and Biological Casualties

Publishing House IRITA
ISBN 978-954-9993-91-2

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MEDICAL MANAGEMENT OF CHEMICAL AND BIOLOGICAL CASUALTIES
Contents

Preface ……………………………………………………………….. 11

Part 1

NEW APPROACHES IN ORGANISATION OF
EMERGENCY RESPONSE AND COUNTERACTION TO CHEM-
ICAL AND BIOLOGICAL TERRORISM……………....… 13

Chapter 1
Military Medical Academy In Emergency Response In Bulgaria …..... 15
Tonev S.

Chapter 2
Specificity of the Interaction between the Bulgarian Ministry
of Health with the Other Goevrnnment Agencies in the Event of
Chemical Incidents…………………………………………………...... 26
Zhelev E., Gigov K. and Kolev S.

Chapter 3
Medical Support in Case of Chemical and Biological Threat………….35
Kanev K.

Chapter 4
Clinical Particularities and Strategic Complex Advanced Therapeutic
Program Against the Toxic Chemical and Biological Traumatism and
Terrorism………………………………………………………………...…… 41
Monov A.

Chapter 5
Military Medical Readiness for Chemical and Biological
Terrorists’ attacks…………………………………………………...…. 45
Kostadinov R., Dimitrov A. and Kanev K.

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S. Tonev, K. Kanev, C. Dishovsky
Chapter 6
Unified Strategic Doctrine Against the Contemporary
Traumatism and Terrorism…………………………………....……… 53
Monov A.

Chapter 7
Contemporary Trends in Computer Aided Tools Development for
Enhancing Chemical Accidents Medical Support…………………..… 56
Gigov K., Dragnev V. and Galabova A.

Chapter 8
Bulgarian National Legislation and Biological
Weapons Proliferation………………………………………………… 60
Galev A.

Chapter 9
What are the Risks of WMD by Organized Crime in
Southeast Europe…………………………………………………...…. 66
Stipetic D. and Orehovec Z.

Chapter 10
Preparedness Against Chemical Terrorism: Poison Information
Centers Roles………………………………………………………….. 71
Soltaninejad K.

Part 2

CHEMICAL AGENTS -
MECHANISMS OF ACTION, DIAGNOSIS , TREATMENT
OF INTOXICATIONS AND PROBLEMS OF CHEMICAL TER-
RORISM………………………………………………………… 81

Chapter 11
Chemical Terrorism, History and Threat Assessment……………...…. 83
Kostadinov R., Kanev K. and Dimov D.

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MEDICAL MANAGEMENT OF CHEMICAL AND BIOLOGICAL CASUALTIES
Chapter 12
Structure, Chemical Reactivity and Toxicity of Organophosphorus
Compounds……………………………………………………….…… 91
Popov I. and Popov G.

Chapter 13
Biological Markers of Intoxication with Nerve Agents –
Biochemical investigations in rats poisoned with tabun…………..…. 100
Dishovsky C., Samnaliev I., Ivanov T. and Petrova I.

Chapter 14
Peculiarities of Treating Water Contaminated with Toxic Chemical
Substances Using Cold Contact Plasma………………………………107
Pivovarov O., Kravchenko O., Tischenko G. and Kublanovsky V.

Chapter 15
Difficulties in the Treatment of Poisoning by Carbamates………..… 115
Tonkolpii V.

Chapter 16
Synthesis of New Reactivators of Cholinesterase………………...… 121
Petrova I., Samnaliev I. and Dishovsky C.

Chapter 17
Investigation of the Efficacy of New Reactivators of Cholinesterase
in Soman and Tabun Inhibited Rat Brain Acetylcholinesterase........... 127
Samnaliev I., Petrova I., Pencheva T. and Dishovsky C.

Chapter 18
What is the Clinical Significance of Oxime and Sodium
Bicarbonate Therapy for Acute Organophosphate Poisoning?............. 135
Vucinic S., Ercegovic G., Djordjevic D., Jovanovic M.,
Vukcevic-perkovic N, Potrebic O. and Zlatkovic M.

Chapter 19
A Test Battery of Combined Methods to Determine Cytotoxic
Effects of Sulfur Mustard and to Investigate Cytoprotective Effects
of PARP Inhibitors…………………………………………………… 144
Balszuweit F., Heinrich A., Kehe K. and Thiermann H.

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S. Tonev, K. Kanev, C. Dishovsky
Chapter 20
Delayed complications of sulfur mustard poisoning in
Iranian veterans………………............................................................. 155
Balali-Mood M. and Balali-Mood B.

Chapter 21
Unfavourable Effects of Dioxins on Environment and
Human Health…………………………………………………..……. 174
Gesheva M. and Radenkova-Saeva J.

Chapter 22
Influence of the Opioid Compounds on the Immune Response……... 182
Radenkova-Saeva J.

Chapter 23
Accidental and Suicidal Self-Poisoning Among Heroin Addicts….… 188
Radenkova-Saeva J.

Chapter 24
Effect of Number of Cigarettes Daily Consumed on Offspring
Sex Ratio……………………………………………………………... 197
Khan U.A. and Adil M.M.

Chapter 25
Epidemiological Research on the Suicidal Attempts and
Suicidal Adjustments Due to Intoxications in the Coming
Generation…………………………………………………………… 205
Barzshka E.

Chapter 26
Re-evaluation of Some Stages of the Classical Conventional
Treatment of Amanita Phalloides Mushroom Poisoning ……………. 216
Trankova V. and Hubenova A.

Chapter 27
Acute methanol intoxications in Varna region during
the period 2000 - 2008 year – an important social problem
- III announcement on this theme………………………………….… 221
Sabeva Y., Yovcheva M., Koleva M., Zlateva S. and Marinov P.

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MEDICAL MANAGEMENT OF CHEMICAL AND BIOLOGICAL CASUALTIES
Chapter 28
Use of Derivatized Reference Standards for Determination
of Dialkylphosphates/Alkylphosphonates in the Coarse of
Organophosphorus Agents’ Exposure Analysis………………………227
Bardarov V.

Chapter 29
Organochlorine and Organophosphate Pesticides Monitoring
in Non Conventional Biological Samples……………………………. 231
Tzatzarakis M. and Tzatzarakis A.

Chapter 30
Possible Problems Connected to Alcohol Abstinence in Case
of Mass Disasters……………………………………………………. 242
Yovcheva M., Zlateva S., Kerezova J., Borisova E. and Sabeva Y.

Chapter 31
Protective Effect of Purified Saponin Mixture from
Astragalus Corniculatus on Toxicity Models In Vitro………………. 249
Micheva M., Kondeva-Burdina M., Krasteva I. and Nikolov S.

Chapter 32
Effects of Multiple D-amphetamine Administration on Some
Hepatic Biochemical Parameters in Spontaneously Hypertensive
Rats (SHR)…………………………………………………………… 262
Simeonova R., Vitcheva V. and Micheva M.

Chapter 33
Protective Effect of New L-Valine Derivatives on Brain Function in
Experimental Model of Aggression in Mice after Social Isolation….. 270
Tancheva L., Petkov V., Encheva E., Novoselski M. and Tsekova D.
Chapter 34
In Vitro and in Vivo Studies on Toxicity and Pharmacological Activity
of New L-Valine Peptidomimetics…………………………………... 277
Tancheva L., Novoselski M., Encheva E., Petkov V., Gorneva G., Tseko-
va D., Chekalarova J., Gurt I., Katz E. and Pavlova E.

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S. Tonev, K. Kanev, C. Dishovsky
Chapter 35
Influence of Nifedipine on Morphine Elimination after Multiple
Administration in Rats……………………………………………….. 285
Vitcheva V., Karova D. and Micheva M.

Chapter 36
Learning, Memory and Biogenic Amine Levels in Rat
Hippocampus after Treatment with New L-Valine
Derivatives………………………………………………………….... 293
Stancheva S., Alova L., Tancheva L., Petkov V., Encheva E.,
Tsekova D. and Novoselski M.

Chapter 37
Hepatic Interaction Between Amphetamine and Calcium Channel
Blocker Nifedipine after Multiple Administrations in Rats….............. 298
Vitcheva V., Simeonova R. and Mitcheva M.

Part 3

BIOLOGICAL AGENTS-
PROBLEMS OF BIOLOGICAL TERRORISM ………………… 305

Chapter 38
Bioterrorism, History and Threat Assessment……………………….. 307
Kostadinov R. and Galbova A.

Chapter 39
Dual-Use Goods in the Production of Biological Weapons…………. 316
Ristanovic E. and Jevtic M.

Chapter 40
Transborder Cooperation on the Protection, Surveillance and
Control of Endemic Diseases………………………………………… 322
Savov E., Doganov B., Kamenov G., Angelov K., Kalvachev Z.,
Rusev A. and Dimova J.

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MEDICAL MANAGEMENT OF CHEMICAL AND BIOLOGICAL CASUALTIES
Chapter 41
Threats and Counteractions Concerning the Use of Viruses for
Biological Terrorism…………………………………………………. 326
Kalvachev Z.

Chapter 42
Generation of Monoclonal Antibody for Real-time Detection of
Chemical and Biological Agents by an Optical Biosensor…………... 336
Baranova E., Biketov S., Gorshkov B., Ksenevich T. and Nikitin P.

Chapter 43
Congo-Crimean Hemorrhagic Fever: Spread and Prophylaxis in
Bulgaria………………………………………………………………. 342
Kamarinchev B., Kovacheva T., Gergova I.,
Alexandrov E. and Mekushinov K.

Chapter 44
Rickettsioses – imminent infections to our present…………………. 347
Alexandrova D., Kunchev A., Shindov M., Kamenova T.,
Kantarjiev T., Teoharova M. and Alexadnrov E.

Chapter 45
Rickettsioses – Emergency Situations – Bioterrorism – Preventive
Therapy………………………………………………………………. 352
Alexandrova D., Kamarinchev B., Shindov M., Kantarjiev T.,
Teoharova M., Macela A. and Alexadnrov E.

Chapter 46
Effective Real-Time PCR SYBR Green System for Early and
Rapid Detection of Coxiella Burnetii………………………….......... 358
Kunchev M., Alexandrov E., Kamarinchev B.,
Gergova I. and Mekushinov K.

Author Index....................................................................................... 363

Subject Index....................................................................................... 369

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S. Tonev, K. Kanev, C. Dishovsky

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